MAPK15

Description		mitogen-activated protein kinase 15
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Autophagosome Golgi Apparatus Centriole Spindle Cytoskeleton Cell-cell Junction Bicellular Tight Junction Axoneme Cytoplasmic Vesicle Ciliary Basal Body Cell Projection Anchoring Junction Meiotic Spindle
	Molecular Function	Nucleotide Binding Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity SH3 Domain Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Regulation Of COPII Vesicle Coating DNA Damage Response Endoplasmic Reticulum Organization Positive Regulation Of Cell Population Proliferation Regulation Of Autophagy Negative Regulation Of Cell Migration Positive Regulation Of Telomere Maintenance Cellular Response To Stress Intracellular Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Dopamine Uptake Regulation Of Cilium Assembly Protein Localization To Ciliary Transition Zone Positive Regulation Of Metaphase/anaphase Transition Of Meiosis I Positive Regulation Of Spindle Assembly
Pathways
Drugs		Acetylsalicylic acid Minocycline Colforsin Fostamatinib
Diseases
GWAS		Obesity-related traits ( 23251661)
Novel Interacting Genes		1 novel interacting genes: RHEB
Interacting Genes		8 interacting genes: CLIC3 CSK GABARAP GABARAPL1 MBP NR3C1 SRC TGFB1I1
Entrez ID		225689
HPRD ID		16867
Ensembl ID		ENSG00000181085
Uniprot IDs		Q8TD08
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Cellular Response To Nutrient Levels Cellular Response To Nitrogen Starvation Autophagosome Assembly Glial Cell Differentiation Positive Regulation Of Protein Metabolic Process Autophagosome Organization Phosphatidylethanolamine Binding Regulation Of Proteolysis GABA Receptor Binding Positive Regulation Of Multicellular Organismal Process Macroautophagy Response To Nutrient Levels Vacuole Organization Signal Transduction Regulation Of Bone Resorption T Cell Costimulation Regulation Of Bone Remodeling Oligodendrocyte Differentiation Non-membrane Spanning Protein Tyrosine Kinase Activity Beta-tubulin Binding Autophagosome Maturation Negative Regulation Of Cell Adhesion Nuclear Glucocorticoid Receptor Activity Cytoskeleton Chemical Synaptic Transmission Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Metalloendopeptidase Activity Regulation Of Protein Metabolic Process Positive Regulation Of TORC1 Signaling TORC1 Signaling Autophagy Mitophagy Autophagosome Membrane Cellular Response To Hormone Stimulus Cytosol Morphogenesis Of An Epithelium Trans-synaptic Signaling Response To Transforming Growth Factor Beta Synaptic Signaling Autophagy Of Mitochondrion Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Regulation Of Tissue Remodeling Autophagosome Cellular Response To Steroid Hormone Stimulus TOR Signaling Positive Regulation Of TOR Signaling Tissue Morphogenesis Protein-disulfide Reductase (glutathione) Activity
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