MAPK15 and MBP

Number of citations of the paper that reports this interaction (PubMedID 11875070)
0

Data Source:
HPRD (in vitro)

		MAPK15	MBP
Description		mitogen-activated protein kinase 15	myelin basic protein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Autophagosome Golgi Apparatus Centriole Spindle Cytoskeleton Cell-cell Junction Bicellular Tight Junction Axoneme Cytoplasmic Vesicle Ciliary Basal Body Cell Projection Anchoring Junction Meiotic Spindle	Nucleus Cytosol Plasma Membrane Cell Surface Membrane Protein-containing Complex Internode Region Of Axon Cell Projection Neuronal Cell Body Myelin Sheath Compact Myelin Synapse Cell Periphery
	Molecular Function	Nucleotide Binding Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity SH3 Domain Binding Protein Serine Kinase Activity	Protease Binding Protein Binding Calmodulin Binding Lipid Binding Structural Constituent Of Myelin Sheath
	Biological Process	MAPK Cascade Regulation Of COPII Vesicle Coating DNA Damage Response Endoplasmic Reticulum Organization Positive Regulation Of Cell Population Proliferation Regulation Of Autophagy Negative Regulation Of Cell Migration Positive Regulation Of Telomere Maintenance Cellular Response To Stress Intracellular Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Dopamine Uptake Regulation Of Cilium Assembly Protein Localization To Ciliary Transition Zone Positive Regulation Of Metaphase/anaphase Transition Of Meiosis I Positive Regulation Of Spindle Assembly	MAPK Cascade Immune Response Chemical Synaptic Transmission Central Nervous System Development Sensory Perception Of Sound Axon Ensheathment Response To Toxic Substance Substantia Nigra Development Positive Regulation Of Interleukin-6 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Maintenance Of Blood-brain Barrier Myelination Membrane Organization Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways			EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs		Acetylsalicylic acid Minocycline Colforsin Fostamatinib
Diseases
GWAS		Obesity-related traits ( 23251661)	Age-related macular degeneration (geographic atrophy) ( 22705344) Blood osmolality (transformed sodium) ( 28360221) Depression in smokers ( 30219690) Erythrocyte cadmium concentration in never smokers ( 27005419) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Verbal declarative memory ( 25648963)
Interacting Genes		8 interacting genes: CLIC3 CSK GABARAP GABARAPL1 MBP NR3C1 SRC TGFB1I1	83 interacting genes: ABL1 ADRB2 APTX ATN1 ATXN1 AURKA BMP2K CCR1 CDK1 CDK12 CDK5 CDK7 CDK8 CDK9 CLK1 CTDSP1 CTDSPL DYRK1B HIPK2 HLA-DRA IKBKE ILK IRAK1 IRAK4 LIMK1 LIMK2 LRRK2 MAG MAP2K1 MAP3K1 MAP3K3 MAP3K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPK8 MAPKAPK5 MELK MICU2 MKNK1 MMP7 NEIL3 NEK9 PAK1 PDGFRL PKN1 PLEKHF2 PLP1 PPP2R5C PRKACA PRKCA PRKCB PRKCD PRKCI PRKCZ PRKDC PRMT1 PRMT5 PTAFR PTPRA RAF1 RAN RPS6KA5 RTN4 SQSTM1 SRPK1 STK16 STK26 STK3 STK39 STK4 TBK1 TLK1 TLK2 TRAF6 TRPM7 TSC1 TSSK6 ULK1
Entrez ID		225689	4155
HPRD ID		16867	01158
Ensembl ID		ENSG00000181085	ENSG00000197971
Uniprot IDs		Q8TD08	P02686
PDB IDs			1BX2 1FV1 1HQR 1K2D 1YMM 1ZGL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Cellular Response To Nutrient Levels Cellular Response To Nitrogen Starvation Autophagosome Assembly Glial Cell Differentiation Positive Regulation Of Protein Metabolic Process Autophagosome Organization Phosphatidylethanolamine Binding Regulation Of Proteolysis GABA Receptor Binding Positive Regulation Of Multicellular Organismal Process Macroautophagy Response To Nutrient Levels Vacuole Organization Signal Transduction Regulation Of Bone Resorption T Cell Costimulation Regulation Of Bone Remodeling Oligodendrocyte Differentiation Non-membrane Spanning Protein Tyrosine Kinase Activity Beta-tubulin Binding Autophagosome Maturation Negative Regulation Of Cell Adhesion Nuclear Glucocorticoid Receptor Activity Cytoskeleton Chemical Synaptic Transmission Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Metalloendopeptidase Activity Regulation Of Protein Metabolic Process Positive Regulation Of TORC1 Signaling TORC1 Signaling Autophagy Mitophagy Autophagosome Membrane Cellular Response To Hormone Stimulus Cytosol Morphogenesis Of An Epithelium Trans-synaptic Signaling Response To Transforming Growth Factor Beta Synaptic Signaling Autophagy Of Mitochondrion Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Regulation Of Tissue Remodeling Autophagosome Cellular Response To Steroid Hormone Stimulus TOR Signaling Positive Regulation Of TOR Signaling Tissue Morphogenesis Protein-disulfide Reductase (glutathione) Activity	Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Kinase Activity Kinase Activity Protein Phosphorylation ATP Binding Phosphorylation Transferase Activity Nucleotide Binding Intracellular Signal Transduction Protein Modification Process Phosphate-containing Compound Metabolic Process MAPK Cascade Protein Metabolic Process Response To Stress Intracellular Signaling Cassette Cellular Response To Stress Peptidyl-serine Phosphorylation Macromolecule Metabolic Process Protein Autophosphorylation Signal Transduction MAP Kinase Activity Regulation Of Cell Differentiation Regulation Of Intracellular Signal Transduction Positive Regulation Of Biosynthetic Process Regulation Of Developmental Process Regulation Of MAPK Cascade Nucleus Positive Regulation Of Developmental Process Magnesium Ion Binding Positive Regulation Of Intracellular Signal Transduction DNA Damage Response RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Development Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Peptidyl-threonine Phosphorylation Nucleoplasm Stress-activated MAPK Cascade Regulation Of Gene Expression Stress-activated Protein Kinase Signaling Cascade Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Cell Surface Receptor Signaling Pathway
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