LSM5 and EXOSC5

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		LSM5	EXOSC5
Gene Name		LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)	exosome component 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Spliceosomal Complex Cytosol	Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin
	Molecular Function	RNA Binding Protein Binding	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Processing RNA Splicing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		mRNA decay by 5' to 3' exoribonuclease Deadenylation-dependent mRNA decay	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS		Palmitic acid (16:0) plasma levels ( 23362303)
Protein-Protein Interactions		11 interactors: EXOSC5 HNRNPD LSM1 LSM2 LSM3 LSM6 LSM7 LSM8 SMN1 SNRPE SNRPF	32 interactors: BIRC2 CALCOCO2 CDK5RAP1 DHRS2 DIS3 DOCK8 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 GOLGA2 IKZF3 KIAA1217 KRT13 LIPG LSM5 MPP6 NUP210 PA2G4 PKM POLR2L REL SFPQ SKIV2L2 TNFAIP1 TRIM54 ZNF558
Entrez ID		23658	56915
HPRD ID		06285	16222
Ensembl ID		ENSG00000106355	ENSG00000077348
Uniprot IDs		Q9Y4Y9	M0R050 Q9NQT4
PDB IDs			2NN6
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process RNA Splicing MRNA Processing RNA Splicing, Via Transesterification Reactions Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Processing MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Aromatic Compound Catabolic Process RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone MRNA Metabolic Process Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Biogenesis Spliceosomal SnRNP Assembly NcRNA Metabolic Process Catabolic Process Ribonucleoprotein Complex Assembly Cellular Metabolic Process Termination Of RNA Polymerase II Transcription Spliceosomal Complex Assembly DNA-templated Transcription, Termination MRNA 3'-end Processing RNA 3'-end Processing RRNA Processing RRNA Metabolic Process Metabolic Process Cellular Macromolecular Complex Assembly Circadian Regulation Of Translation Ribosome Biogenesis Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA DNA Deamination Histone MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Maturation Of SSU-rRNA Ribosomal Small Subunit Biogenesis Regulation Of MRNA Stability Regulation Of RNA Stability	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Processing RRNA Metabolic Process Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay NcRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process Ribonucleoprotein Complex Biogenesis MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process RRNA Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic RNA Metabolic Process Maturation Of 5.8S RRNA Nuclear MRNA Surveillance Aromatic Compound Catabolic Process RNA Surveillance Cellular Macromolecule Catabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression RNA Phosphodiester Bond Hydrolysis Cellular Nitrogen Compound Metabolic Process Catabolic Process Nitrogen Compound Metabolic Process Intracellular MRNA Localization Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing Nucleic Acid Phosphodiester Bond Hydrolysis TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' RNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Metabolic Process RRNA 3'-end Processing Cellular Metabolic Process RNA Localization DNA Deamination Immune System Process Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Immune Response Leukocyte Activation Isotype Switching
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Tagcloud (Difference) ?		angles arrange assemble building heptameric heteroheptameric hexameric incorporate lsm1 lsm2 lsm23 lsm57 lsm6 lsm657 lsm7 monomers nonetheless plastic pockets preferences pull ring sme smf smg solved spliceosomal
Tagcloud (Intersection) ?