LSM5 and PRPF38B

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		LSM5	PRPF38B
Description		LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated	pre-mRNA processing factor 38B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP Cytoplasm Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex	Nucleus Spliceosomal Complex Precatalytic Spliceosome
	Molecular Function	RNA Binding Protein Binding Protein Heterodimerization Activity	RNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing MRNA Catabolic Process RNA Splicing Response To Bacterium	MRNA Processing RNA Splicing
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Body mass index ( 26426971) Extremely high intelligence ( 29520040) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Morning person ( 30696823) Palmitic acid (16:0) levels ( 23362303) Smooth-surface caries ( 24556642)	Bone mineral density (hip) ( 30172743)
Interacting Genes		23 interacting genes: CEBPA CPSF7 DDIT4L EXOSC5 HNRNPD LARP4 LSM1 LSM2 LSM3 LSM6 LSM7 LSM8 PLK3 PRPF38B PRRC2B QKI RBFOX2 SMN1 SNRPE SNRPF SPMIP10 TBPL1 TCL1B	6 interacting genes: CEBPA ESS2 LSM5 RBFOX2 SRPK2 YWHAG
Entrez ID		23658	55119
HPRD ID		06285	07664
Ensembl ID		ENSG00000106355	ENSG00000134186
Uniprot IDs		A0A090N8Y5 Q9Y4Y9	A0A0A0MRN0 Q5VTL8
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process RNA Processing RNA Splicing RNA Metabolic Process RNA Binding RNA Splicing, Via Transesterification Reactions U4/U6 X U5 Tri-snRNP Complex Lsm2-8 Complex U2-type Precatalytic Spliceosome U6 SnRNP Nucleic Acid Metabolic Process Lsm1-7-Pat1 Complex Precatalytic Spliceosome Spliceosomal Complex MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Ribonucleoprotein Complex Macromolecule Metabolic Process Catalytic Step 2 Spliceosome RNA Catabolic Process Spliceosomal SnRNP Assembly U6 SnRNA Binding MRNA Catabolic Process MRNA Binding Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex U12-type Spliceosomal Complex Nucleobase-containing Compound Catabolic Process P-body PICln-Sm Protein Complex Spliceosomal Complex Assembly U7 SnRNP 7-methylguanosine Cap Hypermethylation Nucleus U4 SnRNP Nucleoplasm Methylosome Protein-RNA Complex Assembly Negative Regulation Of Macromolecule Biosynthetic Process U1 SnRNP U5 SnRNP Negative Regulation Of Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of Gene Expression U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome Nucleic Acid Binding	RNA Splicing MRNA Processing RNA Metabolic Process MRNA Metabolic Process RNA Processing Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Macromolecule Metabolic Process Response To Vitamin B2 C/EBP Complex Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Regulation Of MRNA Processing CHOP-C/EBP Complex Protein Kinase C Inhibitor Activity Intracellular Signal Transduction DNA-binding Transcription Factor Binding White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Regulation Of RNA Splicing Nuclear Speck Organization Spliceosomal Complex Lsm1-7-Pat1 Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Protein Domain Specific Binding Response To Phenylpropanoid Nucleus Presynapse Lsm2-8 Complex Fat Cell Proliferation R-loop Processing Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell U6 SnRNP Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Urea Cycle STAT Family Protein Binding Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Phosphorylation-dependent Protein Binding Urea Metabolic Process HMG Box Domain Binding
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