LSM5 and LSM2

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		LSM5	LSM2
Gene Name		LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)	LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Spliceosomal Complex Cytosol	Nucleoplasm Cytosol Catalytic Step 2 Spliceosome
	Molecular Function	RNA Binding Protein Binding	Protein Binding U6 SnRNA Binding Ral GTPase Binding Protein Kinase Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Processing RNA Splicing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways		mRNA decay by 5' to 3' exoribonuclease Deadenylation-dependent mRNA decay	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway mRNA decay by 5' to 3' exoribonuclease Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS		Palmitic acid (16:0) plasma levels ( 23362303)
Protein-Protein Interactions		11 interactors: EXOSC5 HNRNPD LSM1 LSM2 LSM3 LSM6 LSM7 LSM8 SMN1 SNRPE SNRPF	31 interactors: AES BANP C14orf1 CLNS1A CRMP1 DDX20 DNAJA1 EXOSC10 GBP2 KRT13 LNX1 LSM1 LSM3 LSM5 LSM6 LSM7 LSM8 MAGEA6 MEOX2 PRCC RALA REL RSRC1 SF3B2 SMN1 SNRPB SNRPD2 SNRPE TRIM54 ZBTB16 ZNF408
Entrez ID		23658	57819
HPRD ID		06285	06282
Ensembl ID		ENSG00000106355	ENSG00000204392
Uniprot IDs		Q9Y4Y9	Q9Y333
PDB IDs
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process RNA Splicing MRNA Processing RNA Splicing, Via Transesterification Reactions Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Processing MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Aromatic Compound Catabolic Process RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone MRNA Metabolic Process Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Biogenesis Spliceosomal SnRNP Assembly NcRNA Metabolic Process Catabolic Process Ribonucleoprotein Complex Assembly Cellular Metabolic Process Termination Of RNA Polymerase II Transcription Spliceosomal Complex Assembly DNA-templated Transcription, Termination MRNA 3'-end Processing RNA 3'-end Processing RRNA Processing RRNA Metabolic Process Metabolic Process Cellular Macromolecular Complex Assembly Circadian Regulation Of Translation Ribosome Biogenesis Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA DNA Deamination Histone MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Maturation Of SSU-rRNA Ribosomal Small Subunit Biogenesis Regulation Of MRNA Stability Regulation Of RNA Stability	RNA Splicing MRNA Metabolic Process MRNA Processing RNA Splicing, Via Transesterification Reactions RNA Processing MRNA Splicing, Via Spliceosome RNA Metabolic Process Spliceosomal SnRNP Assembly Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Histone MRNA Metabolic Process Nitrogen Compound Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Ribonucleoprotein Complex Assembly RNA Catabolic Process NcRNA Metabolic Process Aromatic Compound Catabolic Process Histone MRNA Catabolic Process Spliceosomal Complex Assembly Cellular Metabolic Process Cellular Macromolecule Catabolic Process Cellular Macromolecular Complex Assembly Metabolic Process Termination Of RNA Polymerase II Transcription Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Catabolic Process DNA-templated Transcription, Termination Transcription From RNA Polymerase II Promoter MRNA 3'-end Processing Membrane Raft Localization Positive Regulation Of Anoikis Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Embryonic Pattern Specification Cellular Process Positive Regulation Of Apoptotic Process Positive Regulation Of NK T Cell Differentiation Positive Regulation Of Programmed Cell Death Transcription, DNA-templated Positive Regulation Of Cell Death Male Germ-line Stem Cell Asymmetric Division Somite Specification
Tagcloud ?		angles arrange assemble building heptameric heteroheptameric hexameric incorporate lsm1 lsm2 lsm23 lsm57 lsm6 lsm657 lsm7 monomers nonetheless plastic pockets preferences pull ring sme smf smg solved spliceosomal	angles arrange assemble building heptameric heteroheptameric hexameric incorporate lsm1 lsm23 lsm5 lsm57 lsm6 lsm657 lsm7 monomers nonetheless plastic pockets preferences pull ring sme smf smg solved spliceosomal
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		angles arrange assemble building heptameric heteroheptameric hexameric incorporate lsm1 lsm2 lsm23 lsm5 lsm57 lsm6 lsm657 lsm7 monomers nonetheless plastic pockets preferences pull ring sme smf smg solved spliceosomal