WBP1 and WWP1

Number of citations of the paper that reports this interaction (PubMedID 9169421)
0

Data Source:
HPRD (in vitro, in vivo)

		WBP1	WWP1
Description		WW domain binding protein 1	WW domain containing E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component		Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding WW Domain Binding	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process		Ubiquitin-dependent Protein Catabolic Process Signal Transduction Central Nervous System Development Protein Ubiquitination Monoatomic Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Symbiont Entry Into Host Cell
Pathways			Downregulation of ERBB4 signaling Stimuli-sensing channels Regulation of RUNX2 expression and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Estimated glomerular filtration rate ( 31152163)
Interacting Genes		10 interacting genes: CACNA1A COPA EPN2 MAGI1 NEDD4 SMCO4 WWP1 WWP2 YAP1 ZMYND10	59 interacting genes: ASH2L ATN1 CBL CDKN1B CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 ENTREP1 EWSR1 FBXL18 HSPB1 IKBKG IL2RG IL6R KLF2 LAPTM5 LATS1 LNX1 LZTR1 MACROH2A2 MIR19A MIR19B1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PRRG4 PTEN PYGM RASA1 RNF11 RTN4 RUNX1 SCNN1A SFTPC SHANK3 SLC2A1 SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53 TP53BP2 TRAF4 TXNIP UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 WASL WBP1 WBP2 YWHAQ ZNF638
Entrez ID		23559	11059
HPRD ID		09510	03811
Ensembl ID		ENSG00000239779	ENSG00000123124
Uniprot IDs		A0A384P602 Q96G27	Q9H0M0
PDB IDs		1JMQ 1K5R	1ND7 2OP7 5HPS 5HPT 6J1X 6J1Y 8EI4 9EQK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Channel Inhibitor Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Notch Signaling Pathway Ubiquitin Ligase Complex Proline-rich Region Binding Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transport Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Notch Signaling Pathway Ubiquitin-protein Transferase Activity Mesenchyme Development Formation Of Structure Involved In A Symbiotic Process Enterocyte Differentiation Positive Regulation Of Motile Cilium Assembly Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Protein K63-linked Ubiquitination Negative Regulation Of Monoatomic Ion Transmembrane Transport Ubiquitin Protein Ligase Activity Regulation Of Potassium Ion Transport Channel Inhibitor Activity Anchoring Junction Regulation Of Cilium Assembly Negative Regulation Of Monoatomic Ion Transport Membrane Phosphothreonine Residue Binding TEAD-YAP Complex Cytoplasm Protein Localization To Cell Leading Edge Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transmembrane Transport Bicellular Tight Junction Lateral Mesoderm Development Cardiac Muscle Tissue Regeneration Symbiont Entry Into Host Cell Pancreatic Juice Secretion Transmembrane Transporter Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Phosphoserine Residue Binding Beta-2 Adrenergic Receptor Binding Ubiquitin-dependent Protein Catabolic Process Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Modification-dependent Protein Catabolic Process Biological Process Involved In Interaction With Host	WW Domain Binding Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Organ Growth Regulation Of Extracellular Matrix Assembly Regulation Of DNA-templated Transcription Response To Hormone Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Developmental Process Regulation Of Signal Transduction Cell Fate Commitment Positive Regulation Of Biosynthetic Process Regulation Of Extracellular Matrix Organization Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Multicellular Organismal Development Modification-dependent Protein Catabolic Process Identical Protein Binding Negative Regulation Of DNA-templated Transcription Ubiquitin Conjugating Enzyme Activity Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Apoptotic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Developmental Process Apoptotic Process Ubiquitin Ligase Activator Activity Enzyme Binding Regulation Of Protein Metabolic Process
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