WBP1 and EPN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		WBP1	EPN2
Description		WW domain binding protein 1	epsin 2
Image			No pdb structure
GO Annotations	Cellular Component		Cytoplasm Endosome Cytosol Plasma Membrane Clathrin Vesicle Coat Clathrin-coated Vesicle Cytoplasmic Vesicle
	Molecular Function	Protein Binding WW Domain Binding	Protein Binding Phospholipid Binding Lipid Binding Clathrin Binding Cadherin Binding
	Biological Process		Endocytosis Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Sprouting Angiogenesis
Pathways			Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS			Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 30224653) White matter hyperintensities ( 32358547) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		10 interacting genes: CACNA1A COPA EPN2 MAGI1 NEDD4 SMCO4 WWP1 WWP2 YAP1 ZMYND10	42 interacting genes: APOE ARRDC1 ARRDC2 ARRDC3 ATXN1 CDIP1 CLTC DAZAP2 EIF3E EPS15 FAIM2 FAM168A FANCM ITSN1 LAPTM5 LITAF MID1 MID2 MLANA PIP4P1 PLEKHB2 PMEPA1 PRKAA2 RNF11 RNF8 RPS27A SMAD1 SNCA SPART TFAP2A THOP1 TRIM23 TRIM26 TRIM62 TUBA1B TXLNA UBA52 UBC WBP1 WBP1L WBP2 YWHAG
Entrez ID		23559	22905
HPRD ID		09510	06271
Ensembl ID		ENSG00000239779	ENSG00000072134
Uniprot IDs		A0A384P602 Q96G27	O95208
PDB IDs		1JMQ 1K5R
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Channel Inhibitor Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Notch Signaling Pathway Ubiquitin Ligase Complex Proline-rich Region Binding Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transport Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Notch Signaling Pathway Ubiquitin-protein Transferase Activity Mesenchyme Development Formation Of Structure Involved In A Symbiotic Process Enterocyte Differentiation Positive Regulation Of Motile Cilium Assembly Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Protein K63-linked Ubiquitination Negative Regulation Of Monoatomic Ion Transmembrane Transport Ubiquitin Protein Ligase Activity Regulation Of Potassium Ion Transport Channel Inhibitor Activity Anchoring Junction Regulation Of Cilium Assembly Negative Regulation Of Monoatomic Ion Transport Membrane Phosphothreonine Residue Binding TEAD-YAP Complex Cytoplasm Protein Localization To Cell Leading Edge Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transmembrane Transport Bicellular Tight Junction Lateral Mesoderm Development Cardiac Muscle Tissue Regeneration Symbiont Entry Into Host Cell Pancreatic Juice Secretion Transmembrane Transporter Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Phosphoserine Residue Binding Beta-2 Adrenergic Receptor Binding Ubiquitin-dependent Protein Catabolic Process Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Modification-dependent Protein Catabolic Process Biological Process Involved In Interaction With Host	Ubiquitin Protein Ligase Binding Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification WW Domain Binding Endosome Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Protein Sequestering Activity Protein Tag Activity Cytoplasmic Side Of Late Endosome Membrane Identical Protein Binding Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Lysosome Ubiquitin Protein Ligase Activity Regulation Of Signal Transduction Protein K6-linked Ubiquitination Protein Binding Intracellular Protein Localization Positive Regulation Of Cell Communication Receptor-mediated Endocytosis Cytoplasm Regulation Of Signaling Protein Polyubiquitination Modification-dependent Protein Catabolic Process Protein Modification Process Negative Regulation Of Signal Transduction Phosphoprotein Binding Clathrin Coat Of Coated Pit Mitochondrial Outer Membrane Positive Regulation Of Protein Ubiquitination Macromolecule Catabolic Process Negative Regulation Of Signaling Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Establishment Of Protein Localization Positive Regulation Of Receptor Catabolic Process Regulation Of Cell Communication Postsynaptic Endocytic Zone Negative Regulation Of Translational Initiation Proteolysis Involved In Protein Catabolic Process Cytoplasmic Translation Lysosomal Membrane Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Signal Transduction Protein Localization To Lysosome Positive Regulation Of Receptor Recycling Cytoplasmic Side Of Lysosomal Membrane Catabolic Process
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