ITGB3BP and RECQL5

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		ITGB3BP	RECQL5
Name		integrin subunit beta 3 binding protein	RecQ like helicase 5
Structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Membrane	Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Cytosol Transcription Preinitiation Complex
	Molecular Function	Protein Binding	Nucleotide Binding RNA Polymerase II Complex Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Identical Protein Binding 3'-5' DNA Helicase Activity Metal Ion Binding Catalytic Activity, Acting On DNA
	Biological Process	Regulation Of DNA-templated Transcription Apoptotic Process Chromosome Segregation Cell Adhesion Signal Transduction CENP-A Containing Chromatin Assembly Positive Regulation Of Epithelial Cell Proliferation Cell Division Negative Regulation Of Epithelial Cell Apoptotic Process	Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process DNA Replication DNA Repair DNA Recombination Regulation Of DNA-templated Transcription DNA Damage Response Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Division Chromosome Separation Cellular Response To Xenobiotic Stimulus Cellular Response To Camptothecin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Mitotic DNA-templated DNA Replication Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	None
GWAS		Mean spheric corpuscular volume ( 32888494 )	Appendicular lean mass ( 33097823 ) Deep white matter hyperintensities ( 32517579 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Periventricular white matter hyperintensities ( 32517579 )
Interacting Genes		42 interacting genes: ACTN2 ANKRD11 APP ARFIP2 C14orf119 CCNA2 CERT1 DDX24 EFHC1 ESR1 GTPBP3 HSF2BP ITGB3 ITGB5 KDM1A KIAA0930 KIFC3 LRRK2 MAPK6 MAPK9 MEIS2 MEOX2 MSGN1 MTA1 NFKB1 NRDE2 NTAQ1 PBX3 PIH1D2 PIK3R3 PKNOX1 RECQL5 RXRA RXRG SNAPC5 SUOX SVIL THRA TRIML2 UBR7 USHBP1 USP20	21 interacting genes: ADCY10P1 ALDH7A1 BNIPL CREB1 CUX1 DDX42 EEF1G ITGB3BP MAPK8IP1 MRE11 MTSS1 MUS81 NBN PCNA PLK1 RAD50 RAD51 STAMBP TIMP1 TOP3A TOP3B
Entrez ID		23421	9400
HPRD ID		09267	04806
Ensembl ID		ENSG00000142856	ENSG00000108469
Uniprot IDs		Q13352	B3KQK2 O94762
PDB IDs		7PB8 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH	4BK0 5LB3 5LB5 5LB8 5LBA 7ZML 7ZMM 7ZMN 7ZMO 7ZMP 7ZMQ 7ZMR 7ZMS 7ZMT 7ZMV 8RL5 8RL6 8RL9 8RLA 9EI1 9EI2 9EI3 9EI4
GO Terms Enriched among Interactors		Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Transcription Regulator Complex DNA-binding Transcription Factor Activity NF-kappaB P50/p65 Complex Positive Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Transcription By RNA Polymerase II Chromatin Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Protein Autoubiquitination Nuclear Steroid Receptor Activity Chromatin Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Retinoic Acid Receptor Signaling Pathway RNA Metabolic Process Hormone-mediated Signaling Pathway Negative Regulation Of MiRNA Transcription Intracellular Signaling Cassette Cellular Response To Oxygen-containing Compound Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Identical Protein Binding Regulation Of MiRNA Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation Nucleic Acid Metabolic Process Intracellular Signal Transduction Regulation Of Thyroid Hormone Receptor Signaling Pathway Regulation Of Protein Autoubiquitination Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Retinoic Acid-responsive Element Binding Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of RNA Metabolic Process Response To Mechanical Stimulus Positive Regulation Of Protein Ubiquitination Cellular Response To Nicotine Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Cellular Response To Manganese Ion Intracellular Receptor Signaling Pathway	Recombinational Repair Chromosome Organization Double-strand Break Repair Via Homologous Recombination DNA Recombination Telomere Maintenance DNA Repair DNA Strand Elongation Double-strand Break Repair Chromosomal Region Telomeric 3' Overhang Formation Telomere Organization Mre11 Complex BRCA1-C Complex Replication Fork Chromosome, Telomeric Region DNA Metabolic Process Homologous Recombination R-loop Processing DNA Damage Response Regulation Of DNA Repair Meiotic Cell Cycle Mitotic G2/M Transition Checkpoint DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition DNA Double-strand Break Processing Negative Regulation Of Mitotic Cell Cycle Reciprocal Meiotic Recombination Cellular Response To Stress Site Of Double-strand Break DNA Damage Checkpoint Signaling Nucleus Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity PML Body Mitotic G2 DNA Damage Checkpoint Signaling Chromosome Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Replication Fork Processing Negative Regulation Of Cell Cycle Process Negative Regulation Of DNA Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of DNA Repair