ITGB3BP and RXRG

Number of citations: 63 (PubMedID 11713274)
Data Source: BioGRID (two hybrid, two hybrid)

		ITGB3BP	RXRG
Name		integrin subunit beta 3 binding protein	retinoid X receptor gamma
Structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Membrane	Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Retinoic Acid-responsive Element Binding Metal Ion Binding Molecular Condensate Scaffold Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Apoptotic Process Chromosome Segregation Cell Adhesion Signal Transduction CENP-A Containing Chromatin Assembly Positive Regulation Of Epithelial Cell Proliferation Cell Division Negative Regulation Of Epithelial Cell Apoptotic Process	Regulation Of DNA-templated Transcription Nervous System Development Cell Differentiation Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Nuclear Receptor transcription pathway Signaling by Retinoic Acid
Drugs		None	Adapalene Bexarotene Rosiglitazone Acitretin Alitretinoin Tretinoin Etretinate Bezafibrate Phthalic Acid Doconexent
GWAS		Mean spheric corpuscular volume ( 32888494 )	AIDS ( 19754311 ) Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder ( 27890468 ) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Macular thickness ( 30535121 ) Menarche (age at onset) ( 21102462 25231870 27182965 29773799 ) Metabolite levels ( 23823483 ) Personality traits in bipolar disorder ( 21368711 ) Proportion of activated microglia (midfrontal cortex) ( 30679421 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		42 interacting genes: ACTN2 ANKRD11 APP ARFIP2 C14orf119 CCNA2 CERT1 DDX24 EFHC1 ESR1 GTPBP3 HSF2BP ITGB3 ITGB5 KDM1A KIAA0930 KIFC3 LRRK2 MAPK6 MAPK9 MEIS2 MEOX2 MSGN1 MTA1 NFKB1 NRDE2 NTAQ1 PBX3 PIH1D2 PIK3R3 PKNOX1 RECQL5 RXRA RXRG SNAPC5 SUOX SVIL THRA TRIML2 UBR7 USHBP1 USP20	33 interacting genes: CAMK2B CEBPZ CHGB CKMT1A CKMT1B CREBBP DCK HOXD4 ITGB3BP LRSAM1 MAP4 MPPED2 NCOA6 NCOR2 NR0B2 NR1H2 NR1H3 NR1H4 NR1I2 NR4A1 NRIP1 PICK1 PNO1 PPARA PPARD PPARG RARA RARB RARG SRF THRA THRB VDR
Entrez ID		23421	6258
HPRD ID		09267	01579
Ensembl ID		ENSG00000142856	ENSG00000143171
Uniprot IDs		Q13352	A0A087WZ88 F1D8Q7 F1T097 P48443
PDB IDs		7PB8 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH	2GL8 7A79
GO Terms Enriched among Interactors		Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Transcription Regulator Complex DNA-binding Transcription Factor Activity NF-kappaB P50/p65 Complex Positive Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Transcription By RNA Polymerase II Chromatin Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Protein Autoubiquitination Nuclear Steroid Receptor Activity Chromatin Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Retinoic Acid Receptor Signaling Pathway RNA Metabolic Process Hormone-mediated Signaling Pathway Negative Regulation Of MiRNA Transcription Intracellular Signaling Cassette Cellular Response To Oxygen-containing Compound Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Identical Protein Binding Regulation Of MiRNA Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation Nucleic Acid Metabolic Process Intracellular Signal Transduction Regulation Of Thyroid Hormone Receptor Signaling Pathway Regulation Of Protein Autoubiquitination Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Retinoic Acid-responsive Element Binding Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of RNA Metabolic Process Response To Mechanical Stimulus Positive Regulation Of Protein Ubiquitination Cellular Response To Nicotine Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Cellular Response To Manganese Ion Intracellular Receptor Signaling Pathway	Nuclear Receptor Activity Nuclear Retinoid X Receptor Binding Intracellular Receptor Signaling Pathway RNA Polymerase II Transcription Regulator Complex Nuclear Receptor-mediated Signaling Pathway Retinoic Acid Receptor Signaling Pathway Chromatin Sequence-specific DNA Binding Hormone-mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process MRNA Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cholesterol Storage Negative Regulation Of MiRNA Transcription Negative Regulation Of RNA Metabolic Process MRNA Transcription Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Transcription Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Chromatin DNA Binding Regulation Of RNA Biosynthetic Process Regulation Of MiRNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Lipid Storage Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Ketone Metabolic Process DNA-templated Transcription Negative Regulation Of Macrophage Derived Foam Cell Differentiation DNA Binding Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor Binding Trachea Cartilage Development Regulation Of Lipid Storage