ITGB3BP and UBR7

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ITGB3BP	UBR7
Description		integrin subunit beta 3 binding protein	ubiquitin protein ligase E3 component n-recognin 7
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Membrane
	Molecular Function	Protein Binding	Molecular_function Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of DNA-templated Transcription Apoptotic Process Chromosome Segregation Cell Adhesion Signal Transduction CENP-A Containing Chromatin Assembly Positive Regulation Of Epithelial Cell Proliferation Cell Division Negative Regulation Of Epithelial Cell Apoptotic Process	Biological_process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Mean spheric corpuscular volume ( 32888494)	Body mass index ( 26426971)
Interacting Genes		42 interacting genes: ACTN2 ANKRD11 APP ARFIP2 C14orf119 CCNA2 CERT1 DDX24 EFHC1 ESR1 GTPBP3 HSF2BP ITGB3 ITGB5 KDM1A KIAA0930 KIFC3 LRRK2 MAPK6 MAPK9 MEIS2 MEOX2 MSGN1 MTA1 NFKB1 NRDE2 NTAQ1 PBX3 PIH1D2 PIK3R3 PKNOX1 RECQL5 RXRA RXRG SNAPC5 SUOX SVIL THRA TRIML2 UBR7 USHBP1 USP20	7 interacting genes: H2BC3 H3C1 H3C15 ITGB3BP OGT UBE2E1 UBQLN4
Entrez ID		23421	55148
HPRD ID		09267	16602
Ensembl ID		ENSG00000142856	ENSG00000012963
Uniprot IDs		Q13352	Q8N806
PDB IDs		7PB8 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH
Enriched GO Terms of Interacting Partners?		Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Transcription Regulator Complex DNA-binding Transcription Factor Activity NF-kappaB P50/p65 Complex Positive Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Transcription By RNA Polymerase II Chromatin Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Protein Autoubiquitination Nuclear Steroid Receptor Activity Chromatin Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Retinoic Acid Receptor Signaling Pathway RNA Metabolic Process Hormone-mediated Signaling Pathway Negative Regulation Of MiRNA Transcription Intracellular Signaling Cassette Cellular Response To Oxygen-containing Compound Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Identical Protein Binding Regulation Of MiRNA Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation Nucleic Acid Metabolic Process Intracellular Signal Transduction Regulation Of Thyroid Hormone Receptor Signaling Pathway Regulation Of Protein Autoubiquitination Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Retinoic Acid-responsive Element Binding Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of RNA Metabolic Process Response To Mechanical Stimulus Positive Regulation Of Protein Ubiquitination Cellular Response To Nicotine Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Cellular Response To Manganese Ion Intracellular Receptor Signaling Pathway	Chromosome Chromatin Organization Structural Constituent Of Chromatin Nucleosome Assembly Nucleosome Nucleosome Organization Nucleoplasm Protein-DNA Complex Assembly Chromatin Remodeling Protein Heterodimerization Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Protein-containing Complex Assembly Nuclear Proteasome Complex Nucleus Protein-containing Complex Organization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein O-acetylglucosaminyltransferase Activity Negative Regulation Of Autophagosome Maturation ISG15 Transferase Activity ISG15-protein Conjugation Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Cytosolic Proteasome Complex Protein-containing Complex Regulation Of Proteasomal Protein Catabolic Process Carbon Catabolite Regulation Of Transcription Regulation Of Transcription By Glucose K48-linked Polyubiquitin Modification-dependent Protein Binding NSL Complex CENP-A Containing Chromatin Assembly Regulation Of Macromolecule Metabolic Process
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