SIRT1 and MCL1

Number of citations of the paper that reports this interaction (PubMedID 34758305)
62

Data Source:
BioGRID (enzymatic study)

		SIRT1	MCL1
Description		sirtuin 1	MCL1 apoptosis regulator, BCL2 family member
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Euchromatin Heterochromatin Fibrillar Center Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Chromatin Silencing Complex Nucleolus Cytoplasm Mitochondrion Cytosol PML Body Protein-containing Complex RDNA Heterochromatin ESC/E(Z) Complex ENoSc Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Bcl-2 Family Protein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity NAD+ Poly-ADP-ribosyltransferase Activity Histone Deacetylase Activity Enzyme Inhibitor Activity Protein Binding Enzyme Activator Activity Transferase Activity Nuclear Receptor Binding Histone Deacetylase Activity, NAD-dependent Deacetylase Activity Enzyme Binding Protein Domain Specific Binding Histone H3K14 Deacetylase Activity, NAD-dependent Protein Lysine Deacetylase Activity NAD-dependent Protein Lysine Deacetylase Activity Histone Binding Identical Protein Binding HLH Domain Binding BHLH Transcription Factor Binding Metal Ion Binding Histone H3K9 Deacetylase Activity, NAD-dependent Histone H4K16 Deacetylase Activity, NAD-dependent Mitogen-activated Protein Kinase Binding NAD+ Binding NAD-dependent Protein-lysine Depropionylase Activity DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity Histone H4K12 Deacetylase Activity, Hydrolytic Mechanism Histone H3K Deacetylase Activity NAD-dependent Protein Lysine Delactylase Activity NAD-dependent Protein Decrotonylase Activity Histone Decrotonylase Activity, NAD-dependent Keratin Filament Binding NAD+-protein Mono-ADP-ribosyltransferase Activity Promoter-specific Chromatin Binding	Protein Binding Protein Transmembrane Transporter Activity Channel Activity Protein Heterodimerization Activity BH Domain Binding BH3 Domain Binding
	Biological Process	Single Strand Break Repair Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Formation Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Synthesis Involved In DNA Repair Angiogenesis Ovulation From Ovarian Follicle Intracellular Glucose Homeostasis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Adaptive Immune Response Gluconeogenesis Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Protein Deacetylation Triglyceride Mobilization Apoptotic Process DNA Damage Response Response To Oxidative Stress Transforming Growth Factor Beta Receptor Signaling Pathway Spermatogenesis Regulation Of Mitotic Cell Cycle Muscle Organ Development Circadian Rhythm Positive Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Starvation Negative Regulation Of Gene Expression Regulation Of Centrosome Duplication Negative Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Storage Regulation Of Glucose Metabolic Process Positive Regulation Of Macroautophagy Protein Ubiquitination Peptidyl-lysine Acetylation Triglyceride Biosynthetic Process Cell Differentiation Macrophage Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Prostaglandin Biosynthetic Process Heterochromatin Formation Subtelomeric Heterochromatin Formation Protein Destabilization Negative Regulation Of TOR Signaling Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Insulin Circadian Regulation Of Gene Expression Leptin-mediated Signaling Pathway Regulation Of Smooth Muscle Cell Apoptotic Process Hippo Signaling Negative Regulation Of Hippo Signaling Intracellular Triglyceride Homeostasis Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Cell Population Proliferation Cellular Response To Glucose Starvation Negative Regulation Of Phosphorylation Response To Hydrogen Peroxide Behavioral Response To Starvation Cholesterol Homeostasis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Leptin Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Gluconeogenesis Positive Regulation Of DNA Repair Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By Glucose Positive Regulation Of Insulin Receptor Signaling Pathway Regulation Of Lipid Biosynthetic Process Rhythmic Process Regulation Of Developmental Process White Fat Cell Differentiation Positive Regulation Of Smooth Muscle Cell Differentiation Regulation Of Multicellular Organismal Process Attachment Of Mitotic Spindle Microtubules To Kinetochore Maintenance Of Nucleus Location Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Fatty Acid Homeostasis Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Small Molecule Metabolic Process Cellular Response To Hydrogen Peroxide Regulation Of Bile Acid Biosynthetic Process UV-damage Excision Repair Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Ionizing Radiation Signal Transduction By P53 Class Mediator Tricarboxylic Acid Metabolic Process Regulation Of Brown Fat Cell Differentiation Stress-induced Premature Senescence Energy Homeostasis Protein Depropionylation DNA Repair-dependent Chromatin Remodeling Regulation Of Cellular Response To Heat Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Acetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Adipose Tissue Development Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Cellular Response To Testosterone Stimulus Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Cellular Senescence Positive Regulation Of Cellular Senescence Positive Regulation Of Double-strand Break Repair	Cell Fate Determination Release Of Cytochrome C From Mitochondria Apoptotic Process DNA Damage Response Mitochondrial Fusion Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Autophagy Cellular Homeostasis Cell Differentiation Response To Cytokine Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Transmembrane Transport Protein Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intracellular Signal Transduction Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Anoikis Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Regulation of HSF1-mediated heat shock response SIRT1 negatively regulates rRNA expression SIRT1 negatively regulates rRNA expression Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation Heme signaling Negative Regulation of CDH1 Gene Transcription MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of MITF-M dependent genes involved in metabolism Transcriptional and post-translational regulation of MITF-M expression and activity Expression of BMAL (ARNTL), CLOCK, and NPAS2	Interleukin-4 and Interleukin-13 signaling Signaling by ALK fusions and activated point mutants
Drugs		Resveratrol Selisistat Cambinol
Diseases
GWAS		Atrial fibrillation ( 30061737) Chronotype ( 30696823) Diverticular disease ( 30177863) Molybdenum levels ( 26025379) Pulse pressure ( 30224653)	Blood protein levels ( 30072576) Coffee consumption ( 31959922) Coronary artery disease ( 29212778) Eosinophil count ( 27863252) FEV1 ( 30804560) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 30804560) Mean corpuscular hemoglobin ( 32888494) Melanoma ( 21983785) Monocyte count ( 29403010) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Rhegmatogenous retinal detachment ( 23585552) Sum eosinophil basophil counts ( 27863252) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		69 interacting genes: AFP AKT1 AR BAZ1B BCL11A BHLHE41 BMAL1 BRIP1 CCAR2 CDK2 CDK6 CENATAC CHFR CLOCK CTTN CUL4B E2F1 EP300 ESRRA EZH2 FOS FOXM1 FOXO1 FOXO3 FZR1 GAPDH H1-5 H3C1 HES1 HEY2 HIC1 HIPK2 HNF4A HOXB9 MAPK8 MCL1 MPHOSPH8 MYCN NBN NDN NEDD8 NMNAT1 NR1H2 NR1H3 NR1H4 PML PPARA PPARG PPARGC1A PRMT1 PSME3 RARA RELA RICTOR RPS19BP1 RRP8 SATB1 SETD7 SMAD7 SNW1 SOX2-OT STK11 STK4 SUMO2 TP53 TP73 TRIM28 UBE2I VDR	40 interacting genes: APEX1 BAD BAK1 BAX BBC3 BCL2L1 BCL2L11 BID BIK BMF BOK BTRC CASP3 CDC20 CHRM4 DAD1 FBXW11 GSK3A GSK3B HIF1A HRK HUWE1 KCNF1 MAPK1 MAPK10 PCNA PIN1 PMAIP1 SIRT1 SIRT2 SIRT3 STX8 TNKS TPT1 TRAF6 TRIM11 UBXN6 UHRF2 USP9X VDAC1
Entrez ID		23411	4170
HPRD ID		08381	08870
Ensembl ID		ENSG00000096717	ENSG00000143384
Uniprot IDs		A8K128 B0QZ35 E9PC49 Q96EB6	A0A087WT64 C8YZ26 Q07820
PDB IDs		4I5I 4IF6 4IG9 4KXQ 4ZZH 4ZZI 4ZZJ 5BTR 8ANB	2KBW 2MHS 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 3WIX 3WIY 4BPI 4BPJ 4HW2 4HW3 4HW4 4OQ5 4OQ6 4WGI 4WMR 4WMS 4WMT 4WMU 4WMV 4WMW 4WMX 4ZBF 4ZBI 5C3F 5C6H 5FC4 5FDO 5FDR 5IEZ 5IF4 5JSB 5KU9 5LOF 5MES 5MEV 5UUM 5VKC 5VX2 5W89 5W8F 6B4L 6B4U 6BW2 6BW8 6FS0 6FS1 6FS2 6MBD 6MBE 6NE5 6O4U 6O6F 6O6G 6OQB 6OQC 6OQD 6OQN 6OVC 6P3P 6QB3 6QB4 6QB6 6QFC 6QFI 6QFM 6QFQ 6QGD 6QXJ 6QYK 6QYL 6QYN 6QYO 6QYP 6QZ5 6QZ6 6QZ7 6QZ8 6QZB 6STJ 6U63 6U64 6U65 6U67 6U6F 6UA3 6UAB 6UD2 6UDI 6UDT 6UDU 6UDV 6UDX 6UDY 6VBX 6YBG 6YBJ 6YBK 6YBL 6ZIE 7NB4 7NB7 7XGE 8AV9 8EKX 8EL0 8EL1 8G3S 8G3T 8G3U 8G3W 8G3X 8G3Y 8H7B 8IQM 8QSO 8SVY 8T6F 8VJP 8Y1Y 8Y1Z 8Y20 9BCG 9CKN
Enriched GO Terms of Interacting Partners?		Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Chromatin Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Sequence-specific DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Positive Regulation Of Biosynthetic Process DNA Damage Response DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Signal Transduction By P53 Class Mediator Nuclear Receptor Activity Negative Regulation Of Developmental Process Intracellular Receptor Signaling Pathway Regulation Of Circadian Rhythm Macromolecule Metabolic Process Regulation Of Cell Differentiation Chromatin DNA Binding Rhythmic Process Regulation Of Developmental Process Regulation Of Cell Cycle	Regulation Of Mitochondrion Organization Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Release Of Cytochrome C From Mitochondria Apoptotic Mitochondrial Changes Regulation Of Membrane Permeability Regulation Of Apoptotic Process Positive Regulation Of Organelle Organization Regulation Of Programmed Cell Death Regulation Of Organelle Organization Cellular Response To Stress Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Mitochondrial Membrane Organization Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrion Organization Positive Regulation Of Membrane Permeability DNA Damage Response Mitochondrial Outer Membrane Regulation Of Autophagy Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Cellular Response To Stress Regulation Of Neuron Apoptotic Process Mitochondrion Leukocyte Apoptotic Process Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Response To Stress Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Signal Transduction Organelle Organization Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Cellular Component Organization
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