DMXL2 and PCNT

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DMXL2	PCNT
Description		Dmx like 2	pericentrin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle RAVE Complex Synapse Neuronal Dense Core Vesicle	Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Membrane Centriolar Satellite
	Molecular Function	Small GTPase Binding	Protein Binding Calmodulin Binding Molecular Adaptor Activity
	Biological Process	Vacuolar Acidification	Microtubule Cytoskeleton Organization Microtubule Nucleation Mitotic Spindle Organization Signal Transduction Cilium Assembly Positive Regulation Of Intracellular Protein Transport
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Drugs
Diseases			Microcephalic osteodysplastic primordial dwarfism, type II (MOPD II) Seckel syndrome
GWAS		BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) C-reactive protein levels ( 30388399) Intelligence (MTAG) ( 29326435) Triglyceride levels ( 32203549)	Heel bone mineral density ( 30598549) Pre-treatment viral load in HIV-1 infection ( 31219150) S100 calcium-binding protein levels ( 33227023) Treatment resistant depression ( 30468137)
Interacting Genes		5 interacting genes: AKTIP ETS2 MTNR1B PCNT RAB3A	55 interacting genes: AKAP6 AKAP9 ANKRD24 ARHGAP21 CALM1 CALM2 CCP110 CEP55 CEP85L CYTH1 DISC1 DMXL2 DNM1 DNM2 DNM3 DST EIF4G3 FEZ1 HMOX2 HUWE1 KALRN KIF1A KIF5C MACF1 MADD MAP1LC3A MAP1LC3B MRFAP1 MYT1L NECAB1 NIPBL ODF2L PARVB PCM1 PNISR RPRD1A RRBP1 RTRAF SEPTIN7 SHTN1 SPTAN1 SPTBN1 SPTBN2 SRGAP2 ST18 SYNE1 TP53BP1 TRAF3IP1 TUBG1 TUBGCP2 TUBGCP3 UTRN YWHAH YWHAZ YY1AP1
Entrez ID		23312	5116
HPRD ID		10188	05804
Ensembl ID		ENSG00000104093	ENSG00000160299
Uniprot IDs		H0YLM8 Q8TDJ6	O95613
PDB IDs
Enriched GO Terms of Interacting Partners?		Ectodermal Cell Fate Commitment Melatonin Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Constitutive Secretory Pathway Synaptic Vesicle Maturation Regulation Of Presynaptic Dense Core Granule Exocytosis Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Regulation Of Plasma Membrane Repair Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Acrosomal Vesicle Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Dense Core Granule Exocytosis Evoked Neurotransmitter Secretion Maintenance Of Presynaptic Active Zone Structure Clathrin-sculpted Monoamine Transport Vesicle Membrane Sensory Perception Of Touch FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm Primitive Streak Formation Cell Fate Commitment Involved In Formation Of Primary Germ Layer Nuclear Glucocorticoid Receptor Binding Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Vesicle Organization Synaptic Vesicle Clustering Regulation Of Short-term Neuronal Synaptic Plasticity Presynaptic Active Zone Organization Positive Regulation Of Protein Binding HOPS Complex Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Plasma Membrane Organization Myosin V Binding Synaptic Vesicle Recycling Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Nervous System Process Regulation Of Circadian Sleep/wake Cycle, Sleep Ubiquitin-like Protein Transferase Activity Positive Regulation Of Circadian Rhythm Regulation Of Protein Transport GTP-dependent Protein Binding	Cytoskeleton Microtubule Cell Projection Organelle Organization Cytoplasm Centrosome Microtubule Binding Cell Projection Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Microtubule-based Process Actin Binding Centriole Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Organization Spectrin Identical Protein Binding Microtubule Nucleation Gamma-tubulin Complex Cell Projection Assembly Cellular Component Assembly Transmembrane Transporter Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Vesicle Scission Microtubule Minus-end Binding Ciliary Basal Body Microtubule Organizing Center Structural Constituent Of Cytoskeleton Transport Along Microtubule Microtubule Cytoskeleton Cytosol Plasma Membrane Bounded Cell Projection Assembly Organelle Localization Sarcomere Establishment Of Organelle Localization Cell Leading Edge Pericentriolar Material Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Actin Filament Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Calcium Channel Complex Polar Microtubule Actin Filament-based Process Microtubule-based Transport Cadherin Binding Regulation Of Cellular Component Organization Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?