MPRIP and RACGAP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MPRIP	RACGAP1
Description		myosin phosphatase Rho interacting protein	Rac GTPase activating protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Actin Cytoskeleton	Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm Mitochondrion Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Midbody Cytoplasmic Vesicle Cleavage Furrow Spindle Midzone Extracellular Exosome Mitotic Spindle Flemming Body Centralspindlin Complex
	Molecular Function	Actin Binding Protein Binding Cadherin Binding Actin Filament Binding	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Zinc Ion Binding Lipid Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Alpha-tubulin Binding Gamma-tubulin Binding Metal Ion Binding Beta-tubulin Binding
	Biological Process		Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Monoatomic Ion Transport Signal Transduction Rho Protein Signal Transduction Spermatogenesis Neuroblast Proliferation Cell Differentiation Erythrocyte Differentiation Positive Regulation Of Cytokinesis Regulation Of Embryonic Development Regulation Of Small GTPase Mediated Signal Transduction Mitotic Spindle Midzone Assembly Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Sulfate Transmembrane Transport
Pathways		Signaling by BRAF and RAF1 fusions	MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RAC3 GTPase cycle Kinesins
Drugs
Diseases
GWAS		Diabetic retinopathy ( 21441570) Estimated glomerular filtration rate ( 31152163) Hematocrit ( 32888494) Hemoglobin ( 32888494) Obesity-related traits ( 23251661)
Interacting Genes		17 interacting genes: ATXN7 DSCAM IKBKG LSM8 NOS3 PDE4B PIAS4 PPP1R12A PPP1R12C PTEN RACGAP1 RHOA SMARCA2 USP7 YWHAB YWHAG YWHAQ	32 interacting genes: AURKB BYSL CDK1 CDK3 CHN2 ECT2 HIF1A KIF23 MAP3K10 MAP3K4 MORF4L1 MPRIP NRAS PLK1 PPP2CA PPP2R5E PRC1 PRSS23 PTPA RAC1 RND2 SH3RF1 SLC16A10 SLC26A8 TANK TRAF3IP3 TUBA4A TUBG1 TXNDC11 VAV1 YWHAB YWHAG
Entrez ID		23164	29127
HPRD ID		17591	05402
Ensembl ID		ENSG00000133030	ENSG00000161800
Uniprot IDs		A0A494BZV2 Q6WCQ1 Q8N236	B2RE34 Q9H0H5
PDB IDs			2OVJ 3W6R 3WPQ 3WPS 4B6D 5C2J 5C2K
Enriched GO Terms of Interacting Partners?		Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Intracellular Signaling Cassette Regulation Of Systemic Arterial Blood Pressure By Endothelin Phosphatase Regulator Activity Myosin Phosphatase Regulator Activity Intracellular Signal Transduction Negative Regulation Of Cell Size Homeostasis Of Number Of Cells Focal Adhesion Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Size Protein Domain Specific Binding Regulation Of Gene Expression Regulation Of Cell Adhesion Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Neuron Projection Morphogenesis Cytoplasmic Side Of Plasma Membrane Cell Projection Morphogenesis PML Body Regulation Of Metabolic Process Negative Regulation Of Cell Adhesion Response To Lipopolysaccharide Regulation Of Signal Transduction Response To Molecule Of Bacterial Origin Regulation Of Multicellular Organismal Development Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis Dendritic Spine Central Nervous System Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction 14-3-3 Protein Binding Gamma-tubulin Binding Positive Regulation Of Biosynthetic Process Regulation Of Transport Cytokinetic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Substantia Nigra Development Regulation Of Phosphorylation Regulation Of Systemic Arterial Blood Pressure	Spindle Microtubule Intracellular Signal Transduction Spindle Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly Midbody Spindle Midzone Assembly Protein Phosphatase Type 2A Complex Mitotic Spindle Elongation Microtubule Cytoskeleton Organization Involved In Mitosis Nucleotide Binding Mitotic Cell Cycle Signal Transduction Mitotic Cytokinesis Microtubule Cytoskeleton Regulation Of Protein Localization To Nucleus Regulation Of Attachment Of Spindle Microtubules To Kinetochore Centralspindlin Complex Microtubule-based Process Cytosol Microtubule Cytoskeleton Organization Cell Division Regulation Of Cell Division Regulation Of Protein Modification Process Cytoskeleton-dependent Cytokinesis Mitotic Spindle Organization Spindle Elongation Cytoskeleton Protein Serine Kinase Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Positive Regulation Of Protein Modification Process MAPK Cascade Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Cytokinesis Regulation Of Phosphorus Metabolic Process Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Mitotic Sister Chromatid Segregation Intracellular Signaling Cassette Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Intracellular Signal Transduction Phosphorylation-dependent Protein Binding Cell Cycle G2/M Phase Transition Protein Kinase Binding Mitotic Nuclear Membrane Disassembly Mitotic Spindle Midzone Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization
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