MPRIP and PPP1R12A

Number of citations of the paper that reports this interaction (PMID 15545284)
15

Data Source:
HPRD (in vivo, two hybrid)

		MPRIP	PPP1R12A
Gene Name		myosin phosphatase Rho interacting protein	protein phosphatase 1, regulatory subunit 12A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Focal Adhesion Actin Cytoskeleton	Kinetochore Nucleoplasm Cytoplasm Centrosome Focal Adhesion Actin Cytoskeleton Contractile Fiber PTW/PP1 Phosphatase Complex
	Molecular Function	Actin Binding Protein Binding	Enzyme Inhibitor Activity Signal Transducer Activity Protein Binding Phosphatase Regulator Activity Protein Kinase Binding 14-3-3 Protein Binding
	Biological Process		G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Dephosphorylation Mitotic Nuclear Division Signal Transduction Regulation Of Cell Adhesion Regulation Of Myosin-light-chain-phosphatase Activity Negative Regulation Of Catalytic Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleocytoplasmic Transport Centrosome Organization
Pathways			G2/M Transition Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Diabetic retinopathy ( 21441570) Obesity-related traits ( 23251661)	Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		13 interactors: ATXN7 IKBKG LSM8 NOS3 PIAS4 PPP1R12A PPP1R12C RACGAP1 RHOA YTHDC1 YWHAB YWHAG YWHAQ	12 interactors: ATXN10 DMPK IL16 ILK KDM1A MPRIP PRKG1 RHOA ROCK1 ROCK2 SETD7 YWHAG
Entrez ID		23164	4659
HPRD ID		17591	03606
Ensembl ID		ENSG00000133030	ENSG00000058272
Uniprot IDs		Q6WCQ1 Q8N236	B2RAH5 O14974
PDB IDs			2KJY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Intracellular Transport Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intracellular Transport Regulation Of Cellular Localization Intracellular Signal Transduction Regulation Of Mitochondrion Organization Positive Regulation Of Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Organelle Organization Regulation Of Phosphorus Metabolic Process Mitotic Spindle Assembly Regulation Of Cell Death Regulation Of Organelle Organization Microtubule Cytoskeleton Organization Intrinsic Apoptotic Signaling Pathway Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Substantia Nigra Development Positive Regulation Of Cytokinesis Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Death Mitotic Spindle Organization Signaling Regulation Of Establishment Of Protein Localization Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Cell Communication Neural Nucleus Development Positive Regulation Of Transport Mitotic Cell Cycle Regulation Of Cytokinesis Microtubule-based Process Mitotic Nuclear Division Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Cytokinesis, Initiation Of Separation Actomyosin Contractile Ring Assembly Regulation Of Catalytic Activity Apoptotic Signaling Pathway Spindle Assembly Positive Regulation Of Cellular Metabolic Process	Neuron Projection Development Nervous System Development Regulation Of Organelle Organization Generation Of Neurons Regulation Of Cell Differentiation Neuron Development Rho Protein Signal Transduction Neurogenesis Regulation Of Stress Fiber Assembly Cell Development Neuron Differentiation Cell Projection Organization Regulation Of Locomotion Locomotion Ephrin Receptor Signaling Pathway Organelle Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-matrix Adhesion Cell Differentiation Cell Migration Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Blood Coagulation Cell Motility Hemostasis Regulation Of Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Keratinocyte Differentiation Regulation Of Cell-substrate Adhesion System Development Regulation Of Cellular Component Organization Regulation Of Body Fluid Levels Wound Healing Chemotaxis Ras Protein Signal Transduction Actin Cytoskeleton Organization Regulation Of Establishment Of Cell Polarity Regulation Of Cell Adhesion Regulation Of Cell Motility Regulation Of Establishment Or Maintenance Of Cell Polarity Neuron Projection Morphogenesis Actin Filament-based Process Cellular Protein Modification Process Protein Phosphorylation Regulation Of Epidermal Cell Differentiation Regulation Of Cellular Component Movement Muscle System Process Response To Wounding Regulation Of Focal Adhesion Assembly
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