GP1BA and SELP

Number of citations of the paper that reports this interaction (PubMedID 10499919)
48

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		GP1BA	SELP
Description		glycoprotein Ib platelet subunit alpha	selectin P
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Exosome Glycoprotein Ib-IX-V Complex	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Platelet Dense Granule Membrane Platelet Alpha Granule Membrane
	Molecular Function	Protein Binding Thrombin-activated Receptor Activity Signaling Receptor Activity	Lipopolysaccharide Binding Integrin Binding Calcium Ion Binding Protein Binding Heparin Binding Carbohydrate Binding Sialic Acid Binding Fucose Binding Glycosphingolipid Binding Metal Ion Binding Calcium-dependent Protein Binding Oligosaccharide Binding
	Biological Process	Cell Morphogenesis Cell Adhesion Cell Surface Receptor Signaling Pathway Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Positive Regulation Of Platelet Activation Platelet Activation Regulation Of Blood Coagulation Megakaryocyte Development Fibrinolysis Release Of Sequestered Calcium Ion Into Cytosol Thrombin-activated Receptor Signaling Pathway	Positive Regulation Of Leukocyte Migration Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Positive Regulation Of Platelet Activation Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Lipopolysaccharide Regulation Of Integrin Activation Response To Cytokine Defense Response To Gram-negative Bacterium Leukocyte Migration Leukocyte Tethering Or Rolling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Defective F9 activation Enhanced binding of GP1BA variant to VWF multimer:collagen Defective binding of VWF variant to GPIb:IX:V	Platelet degranulation Cell surface interactions at the vascular wall
Drugs		Ibuprofen Egaptivon pegol liposomal prostaglandin E1 Dexibuprofen	Heparin N-acetyl-alpha-neuraminic acid Dalteparin Nadroparin Crizanlizumab
Diseases		Bernard-Soulier syndrome; Giant platelet syndrome
GWAS		Blood protein levels ( 30072576) Keratoconus ( 33649486) Mean platelet volume ( 27863252 32888494) Platelet count ( 20139978 22139419 27863252 29403010 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494)	Activated partial thromboplastin time ( 22703881) Blood protein levels ( 30072576) Hippocampal atrophy ( 22745009) Inflammatory bowel disease ( 26192919) L-selectin levels ( 25576479) Late-onset Alzheimer's disease ( 27770636) Monocyte count ( 32888494) Optic disc size ( 31809533) Soluble levels of adhesion molecules ( 20167578) Total ventricular volume ( 21116278)
Interacting Genes		17 interacting genes: CTSG DDIT3 F11 F12 F2 FLNA FLNB GP5 GP9 ITGAM KNG1 OSGEP PIK3R1 SELP TPST1 VWF YWHAZ	10 interacting genes: AP1M1 CD24 EZR FUT4 GP1BA SELPLG SERPING1 SNX17 SNX27 VCAN
Entrez ID		2811	6403
HPRD ID		01976	01433
Ensembl ID		ENSG00000185245	ENSG00000174175
Uniprot IDs		L7UYB8 P07359	B2R785 P16109 Q5R341 Q6NUL9
PDB IDs		1GWB 1M0Z 1M10 1OOK 1P8V 1P9A 1QYY 1SQ0 1U0N 2BP3 3P72 3PMH 4C2A 4C2B 4CH2 4CH8 4MGX 4YR6 6XFQ 8WE2 8WF6 8WFS	1FSB 1G1Q 1G1R 1G1S 1HES
Enriched GO Terms of Interacting Partners?		Regulation Of Platelet Activation Coagulation Blood Coagulation Hemostasis Blood Coagulation, Intrinsic Pathway Positive Regulation Of Platelet Activation Protein Activation Cascade Regulation Of Body Fluid Levels Glycoprotein Ib-IX-V Complex Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Coagulation Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Heparin Binding Protein Maturation Regulation Of Fibrinolysis Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Extracellular Exosome Megakaryocyte Development Calcium Ion Transmembrane Import Into Cytosol Extracellular Space Defense Response To Symbiont Positive Regulation Of Fibrinolysis Defense Response To Other Organism Response To Other Organism Serine-type Peptidase Activity Regulation Of Biological Quality Regulation Of Wound Healing Cell Adhesion Serine-type Endopeptidase Activity Regulation Of Protein Localization To Nucleus Response To External Biotic Stimulus Regulation Of Response To Wounding Defense Response Protein Metabolic Process Regulation Of Cell Activation Regulation Of Multicellular Organismal Process Cell Killing Myeloid Cell Development Calcium Ion Transmembrane Transport Platelet Activation Neutrophil-mediated Killing Of Bacterium Extracellular Matrix Leukocyte Mediated Cytotoxicity Calcium Ion Transport Negative Regulation Of Multicellular Organismal Process	Localization Within Membrane Uropod Fibrinolysis Cell Migration Cell Adhesion Cellular Localization Receptor-mediated Endocytosis Establishment Of Localization In Cell Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Cell Motility Intracellular Protein Localization IgE Receptor Activity Vesicle-mediated Transport Leukocyte Migration Cell Activation Cell Surface Regulation Of Platelet Activation Leukocyte Cell-cell Adhesion Plasma Membrane Raft Immunological Synapse Intracellular Protein Transport Establishment Of Natural Killer Cell Polarity Negative Regulation Of Transforming Growth Factor Beta3 Production B Cell Receptor Transport Into Membrane Raft Chemokine Receptor Transport Out Of Membrane Raft Membrane Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Receptor Internalization Protein Localization To Membrane Regulation Of Hemostasis Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Type I Hypersensitivity External Side Of Plasma Membrane Fc-epsilon Receptor I Complex Lewis X Epitope Biosynthetic Process Leukocyte Adhesive Activation Terminal Web Assembly Early Endosome Endocytic Recycling Glomerular Parietal Epithelial Cell Differentiation Blood Coagulation Regulation Of Immune System Process Interphotoreceptor Matrix Negative Regulation Of Mast Cell Apoptotic Process Serotonin Secretion By Platelet Fc-gamma Receptor III Complex Positive Regulation Of Type III Hypersensitivity
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