GP1BA and GP5

Number of citations: 0 (PubMedID 1730602)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vivo)

		GP1BA	GP5
Name		glycoprotein Ib platelet subunit alpha	glycoprotein V platelet
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Exosome Glycoprotein Ib-IX-V Complex	Plasma Membrane Membrane Extracellular Exosome Glycoprotein Ib-IX-V Complex
	Molecular Function	Protein Binding Thrombin-activated Receptor Activity Signaling Receptor Activity	Protein Binding
	Biological Process	Cell Morphogenesis Cell Adhesion Cell Surface Receptor Signaling Pathway Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Positive Regulation Of Platelet Activation Platelet Activation Regulation Of Blood Coagulation Megakaryocyte Development Fibrinolysis Release Of Sequestered Calcium Ion Into Cytosol Thrombin-activated Receptor Signaling Pathway	Cell Adhesion Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Positive Regulation Of Platelet Activation Megakaryocyte Development Release Of Sequestered Calcium Ion Into Cytosol
Pathways		Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Defective F9 activation Enhanced binding of GP1BA variant to VWF multimer:collagen Defective binding of VWF variant to GPIb:IX:V	Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) Defective F9 activation Enhanced binding of GP1BA variant to VWF multimer:collagen Defective binding of VWF variant to GPIb:IX:V
Drugs		Ibuprofen Egaptivon pegol liposomal prostaglandin E1 Dexibuprofen	None
Diseases		Bernard-Soulier syndrome; Giant platelet syndrome	None
GWAS		Blood protein levels ( 30072576 ) Keratoconus ( 33649486 ) Mean platelet volume ( 27863252 32888494 ) Platelet count ( 20139978 22139419 27863252 29403010 32888494 ) Platelet distribution width ( 27863252 32888494 ) Plateletcrit ( 32888494 )	Mean platelet volume ( 32888494 ) Platelet count ( 32888494 ) Platelet distribution width ( 27863252 32888494 )
Novel Interactors		1 novel interactors: FBXL4	None recorded
Interacting Genes		17 interacting genes: CTSG DDIT3 F11 F12 F2 FLNA FLNB GP5 GP9 ITGAM KNG1 OSGEP PIK3R1 SELP TPST1 VWF YWHAZ	3 interacting genes: F2 GP1BA YWHAZ
Entrez ID		2811	2814
HPRD ID		01976	01431
Ensembl ID		ENSG00000185245	ENSG00000178732
Uniprot IDs		L7UYB8 P07359	P40197
PDB IDs		1GWB 1M0Z 1M10 1OOK 1P8V 1P9A 1QYY 1SQ0 1U0N 2BP3 3P72 3PMH 4C2A 4C2B 4CH2 4CH8 4MGX 4YR6 6XFQ 8WE2 8WF6 8WFS	Not available
GO Terms Enriched among Interactors		Regulation Of Platelet Activation Coagulation Blood Coagulation Hemostasis Blood Coagulation, Intrinsic Pathway Positive Regulation Of Platelet Activation Protein Activation Cascade Regulation Of Body Fluid Levels Glycoprotein Ib-IX-V Complex Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Coagulation Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Heparin Binding Protein Maturation Regulation Of Fibrinolysis Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Extracellular Exosome Megakaryocyte Development Calcium Ion Transmembrane Import Into Cytosol Extracellular Space Defense Response To Symbiont Positive Regulation Of Fibrinolysis Defense Response To Other Organism Response To Other Organism Serine-type Peptidase Activity Regulation Of Biological Quality Regulation Of Wound Healing Cell Adhesion Serine-type Endopeptidase Activity Regulation Of Protein Localization To Nucleus Response To External Biotic Stimulus Regulation Of Response To Wounding Defense Response Protein Metabolic Process Regulation Of Cell Activation Regulation Of Multicellular Organismal Process Cell Killing Myeloid Cell Development Calcium Ion Transmembrane Transport Platelet Activation Neutrophil-mediated Killing Of Bacterium Extracellular Matrix Leukocyte Mediated Cytotoxicity Calcium Ion Transport Negative Regulation Of Multicellular Organismal Process	Thrombin-activated Receptor Signaling Pathway Fibrinolysis Negative Regulation Of Coagulation Negative Regulation Of Blood Coagulation Regulation Of Platelet Activation Negative Regulation Of Hemostasis Negative Regulation Of Wound Healing Platelet Activation Regulation Of Hemostasis Regulation Of Blood Coagulation Coagulation Blood Coagulation Hemostasis Blood Microparticle Regulation Of Sequestering Of Calcium Ion Regulation Of Wound Healing Regulation Of Protein Localization To Nucleus Regulation Of Response To Wounding Synaptic Target Recognition Thrombospondin Receptor Activity Neutrophil-mediated Killing Of Gram-negative Bacterium Regulation Of Body Fluid Levels Glycoprotein Ib-IX-V Complex Thrombin-activated Receptor Activity Golgi Reassembly Phosphoserine Residue Binding Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway External Side Of Plasma Membrane Blood Coagulation, Intrinsic Pathway Establishment Of Golgi Localization Extracellular Exosome Neutrophil-mediated Killing Of Bacterium Cytolysis By Host Of Symbiont Cells Negative Regulation Of Fibrinolysis Positive Regulation Of Platelet Activation Negative Regulation Of Astrocyte Differentiation Regulation Of Lysosome Organization Golgi Localization Antibacterial Innate Immune Response Regulation Of Fibrinolysis Negative Regulation Of Platelet Activation Regulation Of Biological Quality Protein Activation Cascade Neutrophil Mediated Immunity Positive Regulation Of Collagen Biosynthetic Process Megakaryocyte Development Cell Activation Regulation Of Cell Activation Negative Regulation Of Glial Cell Differentiation Positive Regulation Of Blood Coagulation