GP1BA and FLNB

Number of citations of the paper that reports this interaction (PubMedID 9651345)
0

Data Source:
BioGRID (pull down)
HPRD (two hybrid, in vitro)

		GP1BA	FLNB
Description		glycoprotein Ib platelet subunit alpha	filamin B
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Exosome Glycoprotein Ib-IX-V Complex	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Brush Border Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Z Disc Neuronal Cell Body Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Thrombin-activated Receptor Activity Signaling Receptor Activity	RNA Binding Actin Binding Protein Binding Identical Protein Binding Cadherin Binding Actin Filament Binding
	Biological Process	Cell Morphogenesis Cell Adhesion Cell Surface Receptor Signaling Pathway Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Positive Regulation Of Platelet Activation Platelet Activation Regulation Of Blood Coagulation Megakaryocyte Development Fibrinolysis Release Of Sequestered Calcium Ion Into Cytosol Thrombin-activated Receptor Signaling Pathway	Keratinocyte Development Epithelial Cell Morphogenesis Signal Transduction Muscle Organ Development Skeletal Muscle Tissue Development Actin Cytoskeleton Organization Cell Differentiation Cellular Response To Type II Interferon
Pathways		Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Defective F9 activation Enhanced binding of GP1BA variant to VWF multimer:collagen Defective binding of VWF variant to GPIb:IX:V	ISG15 antiviral mechanism
Drugs		Ibuprofen Egaptivon pegol liposomal prostaglandin E1 Dexibuprofen
Diseases		Bernard-Soulier syndrome; Giant platelet syndrome	FLNB-related disorders, including: ; Atelostogenesis, type I; Boomerang dysplasia; Atelosteogenesis, type III; Larsen syndrome Spondylocarpotarsal synostosis syndrome
GWAS		Blood protein levels ( 30072576) Keratoconus ( 33649486) Mean platelet volume ( 27863252 32888494) Platelet count ( 20139978 22139419 27863252 29403010 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494)	A body shape index ( 34021172) Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Eating disorders (purging via substances) ( 23568457) Glaucoma (low intraocular pressure) ( 33627673) Gut microbiota (bacterial taxa) ( 27723756) Height ( 33713608 31217584) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Lymphocyte count ( 32888494) Neutrophil count ( 32888494) Optic cup area ( 31798171 28073927 25631615) Pulse pressure ( 30578418) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Systemic sclerosis ( 31672989) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)
Interacting Genes		17 interacting genes: CTSG DDIT3 F11 F12 F2 FLNA FLNB GP5 GP9 ITGAM KNG1 OSGEP PIK3R1 SELP TPST1 VWF YWHAZ	26 interacting genes: ASB2 ATF7IP DSCAM ERBB2 FBLIM1 FLNA FXR1 GP1BA HSPB1 ITGB1 ITGB3 ITGB6 MLH1 MYBPC2 NPHP1 PLEKHO1 PSEN1 PSEN2 RAD21 RNF216 SMURF2 SUMO2 TRIM55 TSC22D2 TSHR XIAP
Entrez ID		2811	2317
HPRD ID		01976	04543
Ensembl ID		ENSG00000185245	ENSG00000136068
Uniprot IDs		L7UYB8 P07359	O75369
PDB IDs		1GWB 1M0Z 1M10 1OOK 1P8V 1P9A 1QYY 1SQ0 1U0N 2BP3 3P72 3PMH 4C2A 4C2B 4CH2 4CH8 4MGX 4YR6 6XFQ 8WE2 8WF6 8WFS	2DI8 2DI9 2DIA 2DIB 2DIC 2DJ4 2DLG 2DMB 2DMC 2E9I 2E9J 2EE6 2EE9 2EEA 2EEB 2EEC 2EED 2WA5 2WA6 2WA7 3FER 4B7L 5DCP
Enriched GO Terms of Interacting Partners?		Regulation Of Platelet Activation Coagulation Blood Coagulation Hemostasis Blood Coagulation, Intrinsic Pathway Positive Regulation Of Platelet Activation Protein Activation Cascade Regulation Of Body Fluid Levels Glycoprotein Ib-IX-V Complex Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Coagulation Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Heparin Binding Protein Maturation Regulation Of Fibrinolysis Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Extracellular Exosome Megakaryocyte Development Calcium Ion Transmembrane Import Into Cytosol Extracellular Space Defense Response To Symbiont Positive Regulation Of Fibrinolysis Defense Response To Other Organism Response To Other Organism Serine-type Peptidase Activity Regulation Of Biological Quality Regulation Of Wound Healing Cell Adhesion Serine-type Endopeptidase Activity Regulation Of Protein Localization To Nucleus Response To External Biotic Stimulus Regulation Of Response To Wounding Defense Response Protein Metabolic Process Regulation Of Cell Activation Regulation Of Multicellular Organismal Process Cell Killing Myeloid Cell Development Calcium Ion Transmembrane Transport Platelet Activation Neutrophil-mediated Killing Of Bacterium Extracellular Matrix Leukocyte Mediated Cytotoxicity Calcium Ion Transport Negative Regulation Of Multicellular Organismal Process	Cell-cell Adhesion Cell Adhesion Positive Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Protein Activation Cascade Synaptic Membrane Receptor Complex Integrin Complex Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Cells Formation Of Radial Glial Scaffolds Positive Regulation Of L-glutamate Import Across Plasma Membrane Signal Transduction Ruffle Membrane Glycoprotein Ib-IX-V Complex C-X3-C Chemokine Binding Negative Regulation Of Apoptotic Process Regulation Of Anatomical Structure Morphogenesis Anchoring Junction Negative Regulation Of Programmed Cell Death Negative Regulation Of Multicellular Organismal Process Focal Adhesion Cell Migration Aspartic Endopeptidase Activity, Intramembrane Cleaving Cell Activation Gamma-secretase Complex Platelet Aggregation Blood Coagulation, Intrinsic Pathway Regulation Of L-glutamate Import Across Plasma Membrane Notch Receptor Processing Coreceptor Activity Protein Maturation Amyloid-beta Formation Cell Motility Homotypic Cell-cell Adhesion Regulation Of Tumor Necrosis Factor Production Glutamatergic Synapse Ubiquitin Protein Ligase Activity Positive Regulation Of Platelet Activation Cell Morphogenesis Actin Cytoskeleton Organization Wound Healing Positive Regulation Of Locomotion Neuromuscular Junction Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Mesodermal Cell Differentiation Cell Development Virus Receptor Activity
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