MTOR and RHEB

Number of citations of the paper that reports this interaction (PubMedID 33157014)
61

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		MTOR	RHEB
Description		mechanistic target of rapamycin kinase	Ras homolog, mTORC1 binding
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Endomembrane System Membrane PML Body Dendrite Cytoplasmic Vesicle TORC1 Complex TORC2 Complex Phagocytic Vesicle Serine/threonine Protein Kinase Complex	Golgi Membrane Spliceosomal Complex Cytoplasm Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Endomembrane System Postsynaptic Density Membrane Synapse Extracellular Exosome
	Molecular Function	Nucleotide Binding Inositol Hexakisphosphate Binding RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding TFIIIC-class Transcription Factor Complex Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Ribosome Binding Transmembrane Transporter Binding Protein-containing Complex Binding Phosphoprotein Binding Protein Serine Kinase Activity	Nucleotide Binding Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Kinase Binding Protein Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding
	Biological Process	Autophagosome Assembly Regulation Of Cell Growth Cytoplasmic Translation T-helper 1 Cell Lineage Commitment Heart Morphogenesis Heart Valve Morphogenesis Energy Reserve Metabolic Process 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Regulation Of Translational Initiation Ubiquitin-dependent Protein Catabolic Process Inflammatory Response DNA Damage Response Cytoskeleton Organization Lysosome Organization Germ Cell Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Regulation Of Cell Size Cellular Response To Starvation Response To Heat Response To Virus Post-embryonic Development Positive Regulation Of Biosynthetic Process Regulation Of Autophagy Negative Regulation Of Autophagy Positive Regulation Of Autophagy Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Myotube Differentiation Macroautophagy Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Regulation Of Lipid Metabolic Process Neuronal Action Potential Cell Projection Organization Positive Regulation Of Cell Growth Positive Regulation Of Actin Filament Polymerization SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process T Cell Costimulation Ruffle Organization Regulation Of Myelination Protein Destabilization Response To Nutrient Levels Cellular Response To Nutrient Levels Cellular Response To Nutrient TOR Signaling Response To Insulin Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Calcineurin-NFAT Signaling Cascade Cellular Response To Amino Acid Starvation Multicellular Organism Growth TORC1 Signaling TORC2 Signaling Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Response To Amino Acid Anoikis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Translation Negative Regulation Of Cell Size Positive Regulation Of Glycolytic Process Negative Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase III Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Behavioral Response To Pain Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Cardiac Muscle Tissue Development Protein Stabilization Voluntary Musculoskeletal Movement Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cardiac Cell Development Cardiac Muscle Cell Development Cardiac Muscle Contraction Cellular Response To Methionine Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Cellular Response To Hypoxia Cellular Response To Osmotic Stress Regulation Of Cellular Response To Stress Regulation Of Membrane Permeability Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Antibacterial Innate Immune Response Regulation Of Cellular Response To Heat Negative Regulation Of Protein Localization To Nucleus Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of TORC2 Signaling Regulation Of Locomotor Rhythm Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Cytoplasmic Translational Initiation Regulation Of Lysosome Organization Negative Regulation Of Lysosome Organization Positive Regulation Of Pentose-phosphate Shunt Cellular Response To Leucine Starvation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytoplasmic Translation Regulation Of Autophagosome Assembly	Autophagosome Assembly Cytoplasmic Translation Signal Transduction Small GTPase-mediated Signal Transduction Response To Virus Negative Regulation Of Autophagy Regulation Of Macroautophagy Cellular Response To Nutrient Levels Regulation Of TOR Signaling Positive Regulation Of TOR Signaling TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Cell Cycle Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of TORC1 Signaling Regulation Of Type B Pancreatic Cell Development
Pathways		PIP3 activates AKT signaling Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of PTEN gene transcription Amino acids regulate mTORC1 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs		Pimecrolimus Sirolimus Everolimus Rimiducid SF1126 XL765 Ridaforolimus Temsirolimus GSK-1059615 Fostamatinib Oleandrin	Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		A body shape index ( 34021172) Beard thickness ( 26926045) Body mass index ( 25673413) Body mass index and type 2 diabetes (pairwise) ( 33619380) Corneal curvature ( 24963161) Heel bone mineral density ( 28869591) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Carboplatin disposition in epthelial ovarian cancer ( 29367611) Metabolite levels ( 23823483)
Interacting Genes		61 interacting genes: AKT1 AKT1S1 AMBRA1 BCL2L1 C7orf25 CDC37 CFP CLIP1 DCP2 EIF3F EIF4EBP1 EIF4EBP2 EP300 ESR1 FBXO8 FKBP1A FKBP8 FLNA GPHN GSK3B HRAS IRS1 MAF1 MAPKAP1 MLST8 NRAS PA2G4 PCNA PDPK1 PLD2 PLEKHM1 PPP2R2A PREX1 PRKAA1 PRKCA PRKN PRR5L RAB1A RHEB RHEBL1 RICTOR RPS6 RPS6KA1 RPS6KA3 RPS6KB1 RPS6KB2 RPTOR RRAGB SEPTIN2 SKP2 STAT3 SUMO1 TELO2 TERT TRAF6 UBQLN1 ULK1 UVRAG WIPI2 YWHAQ ZNRF2	29 interacting genes: A2M APOE APPBP2 ARIH2 ATM ATR BNIP3 BNIP3L BRAF CREB3 ECSIT FKBP8 HTT MTOR NCAM1 PDE6D PLD1 PSEN1 PSEN2 RABAC1 RAF1 RNF152 RPS6KB1 RPTOR TRIM55 TRIM63 TSC1 TSC2 USP4
Entrez ID		2475	6009
HPRD ID		03134	03188
Ensembl ID		ENSG00000198793	ENSG00000106615
Uniprot IDs		A0A8V8TQ52 P42345	A0A090N900 Q15382
PDB IDs		1AUE 1FAP 1NSG 2FAP 2GAQ 2NPU 2RSE 3FAP 3JBZ 4DRH 4DRI 4DRJ 4FAP 4JSN 4JSP 4JSV 4JSX 4JT5 4JT6 5FLC 5GPG 5H64 5WBH 5WBU 5WBY 5ZCS 6BCU 6BCX 6M4U 6M4W 6SB0 6SB2 6ZWM 6ZWO 7EPD 7OWG 7PE7 7PE8 7PE9 7PEA 7PEB 7PEC 7TZO 7UXC 7UXH 8ER6 8ER7 8ERA 8PPZ 8RCH 8RCK 8RCN 9F44 9F45	1XTQ 1XTR 1XTS 3SEA 3T5G 5YXH 6BCU 6BSX 6BT0 7BTA 7BTC 7BTD
Enriched GO Terms of Interacting Partners?		TOR Signaling Intracellular Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction TORC1 Signaling Regulation Of Autophagy Intracellular Signaling Cassette Regulation Of TOR Signaling TORC2 Signaling Autophagosome Assembly Autophagosome Organization Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Apoptotic Process Cellular Response To Nutrient Levels Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of TOR Signaling Regulation Of Signaling Regulation Of Cell Communication Vacuole Organization Cytoplasm Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Autophagy Regulation Of Translational Initiation Negative Regulation Of Translational Initiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Translation Positive Regulation Of Translational Initiation Insulin Receptor Signaling Pathway Regulation Of Biological Quality Protein Kinase Binding Positive Regulation Of Endothelial Cell Proliferation Regulation Of TORC1 Signaling Response To Nutrient Levels Organelle Organization Positive Regulation Of TORC1 Signaling Positive Regulation Of Cell Population Proliferation Signal Transduction Positive Regulation Of Cell Growth Regulation Of Cellular Component Organization Negative Regulation Of Catabolic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Intracellular Signal Transduction Regulation Of Autophagy Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling TORC1 Signaling TOR Signaling Negative Regulation Of TOR Signaling Regulation Of TOR Signaling Positive Regulation Of Translational Initiation Positive Regulation Of TOR Signaling Response To Nutrient Levels Positive Regulation Of Autophagy Regulation Of Macroautophagy Response To Stress Positive Regulation Of Catabolic Process Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Translation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Translational Initiation Cellular Response To Nutrient Levels Regulation Of Autophagy Of Mitochondrion Regulation Of Translational Initiation Protein Metabolic Process Apoptotic Process Positive Regulation Of Cell Communication Programmed Cell Death Cell Death Cytoplasmic Translation Response To Starvation Signal Transduction Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Golgi Apparatus Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Autophagosome Assembly Positive Regulation Of Metabolic Process Positive Regulation Of Macroautophagy Cellular Response To Starvation Negative Regulation Of Signal Transduction Autophagosome Organization Regulation Of Apoptotic Process Negative Regulation Of Autophagy Regulation Of Mitophagy Protein Catabolic Process Thymus Development Regulation Of Intracellular Signal Transduction
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