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MTOR and RPS6KA1
Number of citations of the paper that reports this interaction (PubMedID
15905173
)
0
Data Source:
HPRD
(in vitro)
MTOR
RPS6KA1
Description
mechanistic target of rapamycin kinase
ribosomal protein S6 kinase A1
Image
GO Annotations
Cellular Component
Golgi Membrane
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Lysosome
Lysosomal Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Endomembrane System
Membrane
PML Body
Dendrite
Cytoplasmic Vesicle
TORC1 Complex
TORC2 Complex
Phagocytic Vesicle
Serine/threonine Protein Kinase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Synapse
Molecular Function
Nucleotide Binding
Inositol Hexakisphosphate Binding
RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding
RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding
RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding
TFIIIC-class Transcription Factor Complex Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Identical Protein Binding
Ribosome Binding
Transmembrane Transporter Binding
Protein-containing Complex Binding
Phosphoprotein Binding
Protein Serine Kinase Activity
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Ribosomal Protein S6 Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
Autophagosome Assembly
Regulation Of Cell Growth
Cytoplasmic Translation
T-helper 1 Cell Lineage Commitment
Heart Morphogenesis
Heart Valve Morphogenesis
Energy Reserve Metabolic Process
'de Novo' Pyrimidine Nucleobase Biosynthetic Process
Regulation Of Translational Initiation
Ubiquitin-dependent Protein Catabolic Process
Inflammatory Response
DNA Damage Response
Cytoskeleton Organization
Lysosome Organization
Germ Cell Development
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Regulation Of Cell Size
Cellular Response To Starvation
Response To Heat
Response To Virus
Post-embryonic Development
Positive Regulation Of Biosynthetic Process
Regulation Of Autophagy
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Positive Regulation Of Lamellipodium Assembly
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Myotube Differentiation
Macroautophagy
Regulation Of Macroautophagy
Negative Regulation Of Macroautophagy
Regulation Of Lipid Metabolic Process
Neuronal Action Potential
Cell Projection Organization
Positive Regulation Of Cell Growth
Positive Regulation Of Actin Filament Polymerization
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
T Cell Costimulation
Ruffle Organization
Regulation Of Myelination
Protein Destabilization
Response To Nutrient Levels
Cellular Response To Nutrient Levels
Cellular Response To Nutrient
TOR Signaling
Response To Insulin
Cellular Response To Insulin Stimulus
Regulation Of Actin Cytoskeleton Organization
Calcineurin-NFAT Signaling Cascade
Cellular Response To Amino Acid Starvation
Multicellular Organism Growth
TORC1 Signaling
TORC2 Signaling
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Response To Amino Acid
Anoikis
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Differentiation
Regulation Of Osteoclast Differentiation
Positive Regulation Of Translation
Negative Regulation Of Cell Size
Positive Regulation Of Glycolytic Process
Negative Regulation Of Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase III
Negative Regulation Of Translational Initiation
Positive Regulation Of Translational Initiation
Negative Regulation Of Insulin Receptor Signaling Pathway
Positive Regulation Of Lipid Biosynthetic Process
Behavioral Response To Pain
Oligodendrocyte Differentiation
Positive Regulation Of Oligodendrocyte Differentiation
Cardiac Muscle Tissue Development
Protein Stabilization
Voluntary Musculoskeletal Movement
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of Keratinocyte Migration
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cardiac Cell Development
Cardiac Muscle Cell Development
Cardiac Muscle Contraction
Cellular Response To Methionine
Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process
Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Cellular Response To Amino Acid Stimulus
Cellular Response To L-leucine
Cellular Response To Hypoxia
Cellular Response To Osmotic Stress
Regulation Of Cellular Response To Stress
Regulation Of Membrane Permeability
Vascular Endothelial Cell Response To Laminar Fluid Shear Stress
Antibacterial Innate Immune Response
Regulation Of Cellular Response To Heat
Negative Regulation Of Protein Localization To Nucleus
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells
Negative Regulation Of TORC2 Signaling
Regulation Of Locomotor Rhythm
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Positive Regulation Of Cytoplasmic Translational Initiation
Regulation Of Lysosome Organization
Negative Regulation Of Lysosome Organization
Positive Regulation Of Pentose-phosphate Shunt
Cellular Response To Leucine Starvation
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cytoplasmic Translation
Regulation Of Autophagosome Assembly
Protein Phosphorylation
Signal Transduction
Chemical Synaptic Transmission
Positive Regulation Of Cell Growth
Negative Regulation Of TOR Signaling
Intracellular Signal Transduction
TORC1 Signaling
Negative Regulation Of Apoptotic Process
Regulation Of Translation In Response To Stress
Positive Regulation Of Cell Differentiation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Hepatocyte Proliferation
Positive Regulation Of Hepatic Stellate Cell Activation
Pathways
PIP3 activates AKT signaling
Macroautophagy
MTOR signalling
mTORC1-mediated signalling
HSF1-dependent transactivation
Energy dependent regulation of mTOR by LKB1-AMPK
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Regulation of PTEN gene transcription
Amino acids regulate mTORC1
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
ERK/MAPK targets
CREB phosphorylation
Senescence-Associated Secretory Phenotype (SASP)
Senescence-Associated Secretory Phenotype (SASP)
Recycling pathway of L1
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
RSK activation
RSK activation
Gastrin-CREB signalling pathway via PKC and MAPK
Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Pimecrolimus
Sirolimus
Everolimus
Rimiducid
SF1126
XL765
Ridaforolimus
Temsirolimus
GSK-1059615
Fostamatinib
Oleandrin
Purvalanol A
Fostamatinib
Diseases
GWAS
A body shape index (
34021172
)
Beard thickness (
26926045
)
Body mass index (
25673413
)
Body mass index and type 2 diabetes (pairwise) (
33619380
)
Corneal curvature (
24963161
)
Heel bone mineral density (
28869591
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Fasting plasma glucose (
31932636
)
Glucose homeostasis traits (
25524916
)
Lymphocyte count (
32888494
)
Mean corpuscular volume (
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Rosacea symptom severity (
29771307
)
Triglyceride levels (
30108155
)
White blood cell count (
32888494
)
Interacting Genes
61 interacting genes:
AKT1
AKT1S1
AMBRA1
BCL2L1
C7orf25
CDC37
CFP
CLIP1
DCP2
EIF3F
EIF4EBP1
EIF4EBP2
EP300
ESR1
FBXO8
FKBP1A
FKBP8
FLNA
GPHN
GSK3B
HRAS
IRS1
MAF1
MAPKAP1
MLST8
NRAS
PA2G4
PCNA
PDPK1
PLD2
PLEKHM1
PPP2R2A
PREX1
PRKAA1
PRKCA
PRKN
PRR5L
RAB1A
RHEB
RHEBL1
RICTOR
RPS6
RPS6KA1
RPS6KA3
RPS6KB1
RPS6KB2
RPTOR
RRAGB
SEPTIN2
SKP2
STAT3
SUMO1
TELO2
TERT
TRAF6
UBQLN1
ULK1
UVRAG
WIPI2
YWHAQ
ZNRF2
88 interacting genes:
ARHGEF11
ARHGEF12
ATM
ATXN3
BAD
CARHSP1
CCT4
CDKN1B
CEBPB
CFL1
CREB1
CREBBP
DDAH2
DEPTOR
DLC1
DLG4
EEF1D
EEF2K
ERBIN
ESR1
ETV1
FGFR1
FOS
GBP2
GMFB
GOPC
GORASP1
GORASP2
GRB2
GRID2IP
GSK3B
HTRA1
L1CAM
LIMK2
LNX1
MAGI1
MAGI2
MAGI3
MAPK1
MAPK3
MAPT
MAST1
MAST2
METTL1
MITF
MPP1
MTOR
MXD1
NFKBIA
NHERF2
NR4A1
NR4A2
NR4A3
PARD3B
PDCD4
PDPK1
PDZD7
PDZK1
PDZRN3
PDZRN4
PHAX
POLDIP3
PPM1G
PPP1R3A
PPP1R9A
PTPN3
RPTOR
SHANK3
SHROOM2
SNTA1
SNTB1
SNTG2
SNX27
SRF
SRSF5
STAT3
SYK
SYNJ2BP
TAMALIN
TOB2
TP53
TSC2
TTK
UBE2T
VCP
WHRN
YBX1
YWHAB
Entrez ID
2475
6195
HPRD ID
03134
03402
Ensembl ID
ENSG00000198793
ENSG00000117676
Uniprot IDs
A0A8V8TQ52
P42345
Q15418
PDB IDs
1AUE
1FAP
1NSG
2FAP
2GAQ
2NPU
2RSE
3FAP
3JBZ
4DRH
4DRI
4DRJ
4FAP
4JSN
4JSP
4JSV
4JSX
4JT5
4JT6
5FLC
5GPG
5H64
5WBH
5WBU
5WBY
5ZCS
6BCU
6BCX
6M4U
6M4W
6SB0
6SB2
6ZWM
6ZWO
7EPD
7OWG
7PE7
7PE8
7PE9
7PEA
7PEB
7PEC
7TZO
7UXC
7UXH
8ER6
8ER7
8ERA
8PPZ
8RCH
8RCK
8RCN
9F44
9F45
2WNT
2Z7Q
2Z7R
2Z7S
3RNY
3TEI
4H3P
4NIF
5CSF
5CSI
5CSJ
5CSN
5N7D
5N7F
5N7G
5V61
5V62
6TWY
7P74
7PC8
7QQL
8WF4
8XOV
Enriched GO Terms of Interacting Partners
?
TOR Signaling
Intracellular Signal Transduction
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
TORC1 Signaling
Regulation Of Autophagy
Intracellular Signaling Cassette
Regulation Of TOR Signaling
TORC2 Signaling
Autophagosome Assembly
Autophagosome Organization
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Cytosol
Regulation Of Apoptotic Process
Cellular Response To Nutrient Levels
Regulation Of Programmed Cell Death
Regulation Of Protein Metabolic Process
Regulation Of Signal Transduction
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Signal Transduction
Positive Regulation Of Catabolic Process
Positive Regulation Of TOR Signaling
Regulation Of Signaling
Regulation Of Cell Communication
Vacuole Organization
Cytoplasm
Post-transcriptional Regulation Of Gene Expression
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Negative Regulation Of Autophagy
Regulation Of Translational Initiation
Negative Regulation Of Translational Initiation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Translation
Positive Regulation Of Translational Initiation
Insulin Receptor Signaling Pathway
Regulation Of Biological Quality
Protein Kinase Binding
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of TORC1 Signaling
Response To Nutrient Levels
Organelle Organization
Positive Regulation Of TORC1 Signaling
Positive Regulation Of Cell Population Proliferation
Signal Transduction
Positive Regulation Of Cell Growth
Regulation Of Cellular Component Organization
Negative Regulation Of Catabolic Process
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Intracellular Signal Transduction
Signal Transduction
Intracellular Signaling Cassette
Cytoplasm
Phosphatase Binding
Regulation Of Cell Development
Positive Regulation Of Cellular Component Organization
Cellular Response To Oxygen-containing Compound
Regulation Of Cellular Component Organization
Nuclear Glucocorticoid Receptor Binding
Regulation Of Cell Population Proliferation
Regulation Of Cell Differentiation
Regulation Of Cellular Response To Heat
Positive Regulation Of Protein-containing Complex Assembly
Cellular Response To Nutrient Levels
TOR Signaling
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Phosphorylation
Regulation Of Signaling
Regulation Of Cell Communication
Negative Regulation Of TOR Signaling
Regulation Of Multicellular Organismal Process
Cellular Response To Hormone Stimulus
Cellular Response To Peptide Hormone Stimulus
Protein Phosphorylation
Cellular Response To Stress
TORC1 Signaling
Regulation Of TORC1 Signaling
Negative Regulation Of TORC1 Signaling
Developmental Process
Negative Regulation Of Signal Transduction
Regulation Of Osteoclast Differentiation
Response To Peptide Hormone
Regulation Of Multicellular Organismal Development
Negative Regulation Of Autophagy
Response To Decreased Oxygen Levels
Regulation Of TOR Signaling
Negative Regulation Of Catabolic Process
Intracellular Protein Localization
Negative Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Organelle Organization
Response To Oxygen Levels
Regulation Of Developmental Process
PDZ Domain Binding
Response To Nutrient Levels
Cellular Response To Cytokine Stimulus
Regulation Of Apoptotic Process
Regulation Of Intracellular Signal Transduction
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Tagcloud (Difference)
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Tagcloud (Intersection)
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