MTOR and FKBP1A

Number of citations of the paper that reports this interaction (PubMedID 36135776)
0

Data Source:
BioGRID (protein complementation assay)
HPRD (in vitro)

		MTOR	FKBP1A
Description		mechanistic target of rapamycin kinase	FKBP prolyl isomerase 1A
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Endomembrane System Membrane PML Body Dendrite Cytoplasmic Vesicle TORC1 Complex TORC2 Complex Phagocytic Vesicle Serine/threonine Protein Kinase Complex	Cytoplasm Cytosol Terminal Cisterna Membrane Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Membrane Cytoplasmic Side Of Membrane Ryanodine Receptor Complex
	Molecular Function	Nucleotide Binding Inositol Hexakisphosphate Binding RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding TFIIIC-class Transcription Factor Complex Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Ribosome Binding Transmembrane Transporter Binding Protein-containing Complex Binding Phosphoprotein Binding Protein Serine Kinase Activity	Peptidyl-prolyl Cis-trans Isomerase Activity Transforming Growth Factor Beta Receptor Binding Calcium Channel Regulator Activity Protein Binding Macrolide Binding FK506 Binding Isomerase Activity Signaling Receptor Inhibitor Activity Type I Transforming Growth Factor Beta Receptor Binding Transmembrane Transporter Binding I-SMAD Binding Activin Receptor Binding
	Biological Process	Autophagosome Assembly Regulation Of Cell Growth Cytoplasmic Translation T-helper 1 Cell Lineage Commitment Heart Morphogenesis Heart Valve Morphogenesis Energy Reserve Metabolic Process 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Regulation Of Translational Initiation Ubiquitin-dependent Protein Catabolic Process Inflammatory Response DNA Damage Response Cytoskeleton Organization Lysosome Organization Germ Cell Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Regulation Of Cell Size Cellular Response To Starvation Response To Heat Response To Virus Post-embryonic Development Positive Regulation Of Biosynthetic Process Regulation Of Autophagy Negative Regulation Of Autophagy Positive Regulation Of Autophagy Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Myotube Differentiation Macroautophagy Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Regulation Of Lipid Metabolic Process Neuronal Action Potential Cell Projection Organization Positive Regulation Of Cell Growth Positive Regulation Of Actin Filament Polymerization SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process T Cell Costimulation Ruffle Organization Regulation Of Myelination Protein Destabilization Response To Nutrient Levels Cellular Response To Nutrient Levels Cellular Response To Nutrient TOR Signaling Response To Insulin Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Calcineurin-NFAT Signaling Cascade Cellular Response To Amino Acid Starvation Multicellular Organism Growth TORC1 Signaling TORC2 Signaling Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Response To Amino Acid Anoikis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Translation Negative Regulation Of Cell Size Positive Regulation Of Glycolytic Process Negative Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase III Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Behavioral Response To Pain Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Cardiac Muscle Tissue Development Protein Stabilization Voluntary Musculoskeletal Movement Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cardiac Cell Development Cardiac Muscle Cell Development Cardiac Muscle Contraction Cellular Response To Methionine Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Cellular Response To Hypoxia Cellular Response To Osmotic Stress Regulation Of Cellular Response To Stress Regulation Of Membrane Permeability Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Antibacterial Innate Immune Response Regulation Of Cellular Response To Heat Negative Regulation Of Protein Localization To Nucleus Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of TORC2 Signaling Regulation Of Locomotor Rhythm Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Cytoplasmic Translational Initiation Regulation Of Lysosome Organization Negative Regulation Of Lysosome Organization Positive Regulation Of Pentose-phosphate Shunt Cellular Response To Leucine Starvation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytoplasmic Translation Regulation Of Autophagosome Assembly	Heart Morphogenesis Protein Folding 'de Novo' Protein Folding Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Localization Negative Regulation Of Activin Receptor Signaling Pathway Protein Refolding T Cell Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Immune Response Protein Maturation Ventricular Cardiac Muscle Tissue Morphogenesis Heart Trabecula Formation Supramolecular Fiber Organization Regulation Of Amyloid Precursor Protein Catabolic Process Amyloid Fibril Formation
Pathways		PIP3 activates AKT signaling Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of PTEN gene transcription Amino acids regulate mTORC1 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	mTORC1-mediated signalling Calcineurin activates NFAT Calcineurin activates NFAT TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR1 LBD Mutants in Cancer Potential therapeutics for SARS SARS-CoV-1 activates/modulates innate immune responses
Drugs		Pimecrolimus Sirolimus Everolimus Rimiducid SF1126 XL765 Ridaforolimus Temsirolimus GSK-1059615 Fostamatinib Oleandrin	Pimecrolimus Tacrolimus (3R)-4-(p-toluenesulfonyl)-1,4-thiazane-3-carboxylicacid-L-phenylalanine ethyl ester {3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid Gpi-1046 Methyl Methylsulfinylmethyl Sulfide FKB-001 Heptyl glucoside L-709,587 (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine 4-hydroxybutan-2-one GPI-1485 Myristic acid (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE Dorsomorphin
Diseases
GWAS		A body shape index ( 34021172) Beard thickness ( 26926045) Body mass index ( 25673413) Body mass index and type 2 diabetes (pairwise) ( 33619380) Corneal curvature ( 24963161) Heel bone mineral density ( 28869591) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Estimated glomerular filtration rate ( 31152163)
Interacting Genes		61 interacting genes: AKT1 AKT1S1 AMBRA1 BCL2L1 C7orf25 CDC37 CFP CLIP1 DCP2 EIF3F EIF4EBP1 EIF4EBP2 EP300 ESR1 FBXO8 FKBP1A FKBP8 FLNA GPHN GSK3B HRAS IRS1 MAF1 MAPKAP1 MLST8 NRAS PA2G4 PCNA PDPK1 PLD2 PLEKHM1 PPP2R2A PREX1 PRKAA1 PRKCA PRKN PRR5L RAB1A RHEB RHEBL1 RICTOR RPS6 RPS6KA1 RPS6KA3 RPS6KB1 RPS6KB2 RPTOR RRAGB SEPTIN2 SKP2 STAT3 SUMO1 TELO2 TERT TRAF6 UBQLN1 ULK1 UVRAG WIPI2 YWHAQ ZNRF2	31 interacting genes: ABI2 ACVR1B ACVRL1 AHSP APP BARD1 BMPR1A CDC42 DCAF11 DHFR ERBB2 ERBB3 ERBB4 FKBP4 GLMN HSP90AA1 ITPR1 MAPT MDM2 MID1 MTOR NLGN3 PPP3CA RYR1 RYR3 SF3B4 TGFB1 TGFB1I1 TGFBR1 TRPC3 YY1
Entrez ID		2475	2280
HPRD ID		03134	01741
Ensembl ID		ENSG00000198793	ENSG00000088832
Uniprot IDs		A0A8V8TQ52 P42345	A0A087WTS4 P62942 Q0VDC6
PDB IDs		1AUE 1FAP 1NSG 2FAP 2GAQ 2NPU 2RSE 3FAP 3JBZ 4DRH 4DRI 4DRJ 4FAP 4JSN 4JSP 4JSV 4JSX 4JT5 4JT6 5FLC 5GPG 5H64 5WBH 5WBU 5WBY 5ZCS 6BCU 6BCX 6M4U 6M4W 6SB0 6SB2 6ZWM 6ZWO 7EPD 7OWG 7PE7 7PE8 7PE9 7PEA 7PEB 7PEC 7TZO 7UXC 7UXH 8ER6 8ER7 8ERA 8PPZ 8RCH 8RCK 8RCN 9F44 9F45	1A7X 1B6C 1BKF 1BL4 1D6O 1D7H 1D7I 1D7J 1EYM 1F40 1FAP 1FKB 1FKD 1FKF 1FKG 1FKH 1FKI 1FKJ 1FKR 1FKS 1FKT 1J4H 1J4I 1J4R 1NSG 1QPF 1QPL 2DG3 2DG4 2DG9 2FAP 2FKE 2ND5 2PPN 2PPO 2PPP 2RSE 3FAP 3H9R 3MDY 4DH0 4FAP 4IPX 4N19 4ODP 4ODQ 4ODR 5I7P 5I7Q 6I1S 6M4U 6OQA 6VCU 6YF0 6YF1 6YF2 6YF3 7EPD 7U0T 7U8D 8CHI 8CHJ 8CHK 8CHL 8CHM 8ER6 8ER7 8ERA 8JCU 8JCV 8JCW 8JCX 8JCY 8JCZ 8JD0 8JD1 8JD2 8JD4 8JGA 8PDF 8POD 8PPZ 8X6P 8XI9 9CHU 9CHV 9CHX
Enriched GO Terms of Interacting Partners?		TOR Signaling Intracellular Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction TORC1 Signaling Regulation Of Autophagy Intracellular Signaling Cassette Regulation Of TOR Signaling TORC2 Signaling Autophagosome Assembly Autophagosome Organization Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Apoptotic Process Cellular Response To Nutrient Levels Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of TOR Signaling Regulation Of Signaling Regulation Of Cell Communication Vacuole Organization Cytoplasm Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Autophagy Regulation Of Translational Initiation Negative Regulation Of Translational Initiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Translation Positive Regulation Of Translational Initiation Insulin Receptor Signaling Pathway Regulation Of Biological Quality Protein Kinase Binding Positive Regulation Of Endothelial Cell Proliferation Regulation Of TORC1 Signaling Response To Nutrient Levels Organelle Organization Positive Regulation Of TORC1 Signaling Positive Regulation Of Cell Population Proliferation Signal Transduction Positive Regulation Of Cell Growth Regulation Of Cellular Component Organization Negative Regulation Of Catabolic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Growth Positive Regulation Of Multicellular Organismal Process Heart Development Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Developmental Process Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Multicellular Organismal Process Regulation Of Intracellular Signal Transduction Anatomical Structure Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Cell Projection Organization Regulation Of Calcium-mediated Signaling Positive Regulation Of Cell Differentiation Cell Development SMAD Binding Regulation Of Developmental Process Regulation Of Cell Growth Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cellular Component Organization Transforming Growth Factor Beta Receptor Activity, Type I Receptor Complex Ubiquitin Protein Ligase Binding Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Developmental Process System Development Positive Regulation Of Lamellipodium Assembly Regulation Of Cell Communication Activin Receptor Activity, Type I Regulation Of Signaling Cellular Component Assembly Signal Transduction Regulation Of Cell Differentiation Regulation Of Superoxide Metabolic Process Negative Regulation Of Cell Differentiation Positive Regulation Of Cellular Component Biogenesis Regulation Of Epithelial Cell Proliferation Positive Regulation Of Growth Regulation Of Supramolecular Fiber Organization Negative Regulation Of Gene Expression Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction
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