FLNB and ITGB6

Number of citations of the paper that reports this interaction (PubMedID 11807098)
75

Data Source:
BioGRID (two hybrid)

		FLNB	ITGB6
Description		filamin B	integrin subunit beta 6
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GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Brush Border Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Z Disc Neuronal Cell Body Phagocytic Vesicle Extracellular Exosome	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin Alphav-beta6 Complex Receptor Complex Anchoring Junction
	Molecular Function	RNA Binding Actin Binding Protein Binding Identical Protein Binding Cadherin Binding Actin Filament Binding	Virus Receptor Activity Integrin Binding Protein Binding Metal Ion Binding
	Biological Process	Keratinocyte Development Epithelial Cell Morphogenesis Signal Transduction Muscle Organ Development Skeletal Muscle Tissue Development Actin Cytoskeleton Organization Cell Differentiation Cellular Response To Type II Interferon	Cell Morphogenesis Inflammatory Response Immune Response Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Wounding Response To Virus Gene Expression Cell Migration Cell Adhesion Mediated By Integrin Wound Healing Surfactant Homeostasis Skin Development Symbiont Entry Into Host Cell Lung Alveolus Development Phospholipid Homeostasis Hard Palate Development Bone Development Bronchiole Development Langerhans Cell Differentiation Enamel Mineralization Cellular Response To Ionizing Radiation Transforming Growth Factor Beta Production Cell-cell Adhesion
Pathways		ISG15 antiviral mechanism	Elastic fibre formation Molecules associated with elastic fibres Integrin cell surface interactions TGF-beta receptor signaling activates SMADs ECM proteoglycans
Drugs			PLN-74809
Diseases		FLNB-related disorders, including: ; Atelostogenesis, type I; Boomerang dysplasia; Atelosteogenesis, type III; Larsen syndrome Spondylocarpotarsal synostosis syndrome
GWAS		A body shape index ( 34021172) Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Eating disorders (purging via substances) ( 23568457) Glaucoma (low intraocular pressure) ( 33627673) Gut microbiota (bacterial taxa) ( 27723756) Height ( 33713608 31217584) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Lymphocyte count ( 32888494) Neutrophil count ( 32888494) Optic cup area ( 31798171 28073927 25631615) Pulse pressure ( 30578418) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Systemic sclerosis ( 31672989) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)	Appendicular lean mass ( 33097823) Asthma (childhood onset) ( 31036433) Eosinophil count ( 32888494) Haemorrhoidal disease ( 33888516) Hematocrit ( 32888494) Hemoglobin ( 32888494) Idiopathic membranous nephropathy ( 21323541) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Tourette syndrome ( 30818990) Type 2 diabetes ( 20418489) Waist circumference adjusted for body mass index ( 25673412)
Interacting Genes		26 interacting genes: ASB2 ATF7IP DSCAM ERBB2 FBLIM1 FLNA FXR1 GP1BA HSPB1 ITGB1 ITGB3 ITGB6 MLH1 MYBPC2 NPHP1 PLEKHO1 PSEN1 PSEN2 RAD21 RNF216 SMURF2 SUMO2 TRIM55 TSC22D2 TSHR XIAP	8 interacting genes: FHL2 FLNA FLNB FN1 ITGAV MAPK1 TGFB1 VTN
Entrez ID		2317	3694
HPRD ID		04543	00947
Ensembl ID		ENSG00000136068	ENSG00000115221
Uniprot IDs		O75369	A0A087WXP3 B4E2B8 E9PEE8 P18564
PDB IDs		2DI8 2DI9 2DIA 2DIB 2DIC 2DJ4 2DLG 2DMB 2DMC 2E9I 2E9J 2EE6 2EE9 2EEA 2EEB 2EEC 2EED 2WA5 2WA6 2WA7 3FER 4B7L 5DCP	4UM8 4UM9 5FFG 5FFO 5NEM 5NER 5NET 5NEU 8TCG 9CZ7 9CZA 9CZD 9CZF
Enriched GO Terms of Interacting Partners?		Cell-cell Adhesion Cell Adhesion Positive Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Protein Activation Cascade Synaptic Membrane Receptor Complex Integrin Complex Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Cells Formation Of Radial Glial Scaffolds Positive Regulation Of L-glutamate Import Across Plasma Membrane Signal Transduction Ruffle Membrane Glycoprotein Ib-IX-V Complex C-X3-C Chemokine Binding Negative Regulation Of Apoptotic Process Regulation Of Anatomical Structure Morphogenesis Anchoring Junction Negative Regulation Of Programmed Cell Death Negative Regulation Of Multicellular Organismal Process Focal Adhesion Cell Migration Aspartic Endopeptidase Activity, Intramembrane Cleaving Cell Activation Gamma-secretase Complex Platelet Aggregation Blood Coagulation, Intrinsic Pathway Regulation Of L-glutamate Import Across Plasma Membrane Notch Receptor Processing Coreceptor Activity Protein Maturation Amyloid-beta Formation Cell Motility Homotypic Cell-cell Adhesion Regulation Of Tumor Necrosis Factor Production Glutamatergic Synapse Ubiquitin Protein Ligase Activity Positive Regulation Of Platelet Activation Cell Morphogenesis Actin Cytoskeleton Organization Wound Healing Positive Regulation Of Locomotion Neuromuscular Junction Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Mesodermal Cell Differentiation Cell Development Virus Receptor Activity	Positive Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Focal Adhesion Endodermal Cell Differentiation Cellular Developmental Process Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Adhesion Regulation Of Locomotion Cell Differentiation Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cell Adhesion Regulation Of Protein Metabolic Process Integrin-mediated Signaling Pathway Cell-matrix Adhesion Positive Regulation Of Integrin-mediated Signaling Pathway Cell Development Cell Migration Blood Microparticle Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell-substrate Adhesion Z Disc Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Protein Activation Cascade Integrin Binding Cell Motility Cell-substrate Adhesion Regulation Of Integrin-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Developmental Process Positive Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Cell Morphogenesis Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Cells Liver Regeneration Extracellular Matrix Binding Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell-substrate Adhesion Positive Regulation Of Protein Import Into Nucleus Animal Organ Development Regulation Of Cellular Component Organization Regulation Of Intracellular Transport Substrate Adhesion-dependent Cell Spreading
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