FLNB and NPHP1

Number of citations of the paper that reports this interaction (PMID 12006559)
12

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		FLNB	NPHP1
Gene Name		filamin B, beta	nephronophthisis 1 (juvenile)
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Plasma Membrane Focal Adhesion Cell Cortex Actin Cytoskeleton Integral Component Of Membrane Z Disc Extracellular Vesicular Exosome	Cytosol Cytoskeleton Cell-cell Junction Adherens Junction Tight Junction Membrane Motile Cilium Photoreceptor Connecting Cilium Ciliary Transition Zone Ciliary Base
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding Poly(A) RNA Binding	Structural Molecule Activity Protein Binding
	Biological Process	Cytoskeletal Anchoring At Plasma Membrane Signal Transduction Skeletal Muscle Tissue Development Cytokine-mediated Signaling Pathway Actin Cytoskeleton Organization Cell Differentiation	Organelle Organization Signal Transduction Excretion Visual Behavior Single Organismal Cell-cell Adhesion Cell Projection Organization Actin Cytoskeleton Organization Cellular Protein Localization Photoreceptor Cell Outer Segment Organization Spermatid Differentiation Retina Development In Camera-type Eye
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes	Organelle biogenesis and maintenance Assembly of the primary cilium Anchoring of the basal body to the plasma membrane
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Eating disorders (purging via substances) ( 23568457)
Protein-Protein Interactions		17 interactors: ASB2 ATF7IP FBLIM1 FLNA GP1BA ITGB1 ITGB3 ITGB6 MLH1 NPHP1 PLEKHO1 PSEN1 PSEN2 RAD21 SMURF2 TRIM55 TSHR	15 interactors: ADAM15 ARHGAP32 BCAR1 FLNA FLNB FLNC INVS KHDRBS1 NPHP3 NPHP4 PAK2 PTK2B TNK2 TUBB UBQLN4
Entrez ID		2317	4867
HPRD ID		04543	09524
Ensembl ID		ENSG00000136068	ENSG00000144061
Uniprot IDs		E7EN95 O75369	B4DQY0 C9JNM7 O15259
PDB IDs		2DI8 2DI9 2DIA 2DIB 2DIC 2DJ4 2DLG 2DMB 2DMC 2E9I 2E9J 2EE6 2EE9 2EEA 2EEB 2EEC 2EED 2WA5 2WA6 2WA7 3FER 4B7L	1S1N
Enriched GO Terms of Interacting Partners?		Cell Activation Cell Adhesion Single Organismal Cell-cell Adhesion Signal Transduction Cellular Response To Stimulus Signaling Cell Communication Viral Entry Into Host Cell Entry Into Host Cell Lymphocyte Activation Cell Junction Assembly Regulation Of Peptidyl-tyrosine Phosphorylation Single-organism Behavior Cell Development Leukocyte Activation Amyloid Precursor Protein Catabolic Process Regulation Of Cellular Process Response To Stimulus Neuron Development Cell Fate Specification Behavior Interaction With Host Embryonic Morphogenesis Beta-amyloid Metabolic Process Amyloid Precursor Protein Metabolic Process Cell Surface Receptor Signaling Pathway Homotypic Cell-cell Adhesion Leukocyte Differentiation Neuron Differentiation Integrin-mediated Signaling Pathway Tissue Development Cell Projection Organization Immune System Development Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Signal Transduction Cell Differentiation Heterotypic Cell-cell Adhesion Regulation Of Epidermal Growth Factor-activated Receptor Activity Response To Stress Developmental Process Leukocyte Activation Involved In Immune Response B Cell Activation Blood Coagulation Cell-matrix Adhesion Hemostasis Endoplasmic Reticulum Calcium Ion Homeostasis	Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Movement Of Cell Or Subcellular Component Actin Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Actin Filament-based Process Cytoskeleton Organization Cellular Response To Stimulus Response To Stimulus Integrin-mediated Signaling Pathway Innate Immune Response Regulation Of Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Tissue Homeostasis Photoreceptor Cell Maintenance Regulation Of Signaling Negative Regulation Of Wnt Signaling Pathway Peptidyl-tyrosine Autophosphorylation Cell Junction Assembly Protein Autophosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Canonical Wnt Signaling Pathway Developmental Process Multicellular Organismal Homeostasis Tissue Development Cell Differentiation Regulation Of Growth Cell Projection Organization Cell Development Positive Regulation Of Endothelial Cell Migration Epithelial To Mesenchymal Transition Cell Adhesion Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Retina Homeostasis Determination Of Stomach Left/right Asymmetry Determination Of Intestine Left/right Asymmetry Locomotion Regulation Of Wnt Signaling Pathway Actin Filament Organization Immune Response Positive Regulation Of Translation Anatomical Structure Development Mitotic Cell Cycle Defense Response Positive Regulation Of Epithelial Cell Migration Regulation Of Cell Growth
Tagcloud ?		actionable algorithms asf1 assuming candidates distinguishing driver genomes grm1 hcf1 hierarchically interpreting involve machinery modules neutral organized passenger pou2f1 precisely presents prkcz psnv psnvs snvs thousands uncovered unexpectedly ways	ahi1 bardet biedl c2cd3 cc2d2a cc2d2b ccdc135 cep76 cilia ciliogenesis ciliopathies dyneins gruber jbts jouberin joubert meckel midasins mks mks6 moxr nephronophthisis nphp4 rpgrip1 rpgrip1l tgl throw ttl
Tagcloud (Difference) ?		actionable algorithms asf1 assuming candidates distinguishing driver genomes grm1 hcf1 hierarchically interpreting involve machinery modules neutral organized passenger pou2f1 precisely presents prkcz psnv psnvs snvs thousands uncovered unexpectedly ways	ahi1 bardet biedl c2cd3 cc2d2a cc2d2b ccdc135 cep76 cilia ciliogenesis ciliopathies dyneins gruber jbts jouberin joubert meckel midasins mks mks6 moxr nephronophthisis nphp4 rpgrip1 rpgrip1l tgl throw ttl
Tagcloud (Intersection) ?