FLNB and PLEKHO1

Number of citations of the paper that reports this interaction (PubMedID 18624398)
0

Data Source:
BioGRID (two hybrid)

		FLNB	PLEKHO1
Description		filamin B	pleckstrin homology domain containing O1
Image
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Brush Border Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Z Disc Neuronal Cell Body Phagocytic Vesicle Extracellular Exosome	Nucleus Cytoplasm Plasma Membrane Membrane Ruffle Membrane Muscle Cell Projection Membrane
	Molecular Function	RNA Binding Actin Binding Protein Binding Identical Protein Binding Cadherin Binding Actin Filament Binding	Protein Binding
	Biological Process	Keratinocyte Development Epithelial Cell Morphogenesis Signal Transduction Muscle Organ Development Skeletal Muscle Tissue Development Actin Cytoskeleton Organization Cell Differentiation Cellular Response To Type II Interferon	Myoblast Fusion Regulation Of Cell Shape Myoblast Migration Lamellipodium Morphogenesis Regulation Of Myoblast Fusion
Pathways		ISG15 antiviral mechanism
Drugs
Diseases		FLNB-related disorders, including: ; Atelostogenesis, type I; Boomerang dysplasia; Atelosteogenesis, type III; Larsen syndrome Spondylocarpotarsal synostosis syndrome
GWAS		A body shape index ( 34021172) Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Eating disorders (purging via substances) ( 23568457) Glaucoma (low intraocular pressure) ( 33627673) Gut microbiota (bacterial taxa) ( 27723756) Height ( 33713608 31217584) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Lymphocyte count ( 32888494) Neutrophil count ( 32888494) Optic cup area ( 31798171 28073927 25631615) Pulse pressure ( 30578418) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Systemic sclerosis ( 31672989) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)	Bipolar disorder ( 31043756) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		26 interacting genes: ASB2 ATF7IP DSCAM ERBB2 FBLIM1 FLNA FXR1 GP1BA HSPB1 ITGB1 ITGB3 ITGB6 MLH1 MYBPC2 NPHP1 PLEKHO1 PSEN1 PSEN2 RAD21 RNF216 SMURF2 SUMO2 TRIM55 TSC22D2 TSHR XIAP	33 interacting genes: ADAM33 AKT1 AKT2 ARLN BNIP2 BRICD5 C10orf88 CEP19 COL8A2 CSNK2A1 CYP4F2 DNAJB1 FLNB IFI35 LRP10 MMD NAPB OGT PSMC5 RPS20 SMAD5 SMURF1 THSD7B TMEM218 TNF TRAF3IP3 TRAF6 TRAM1L1 TSPAN33 TSPO2 USP7 VAMP3 ZFPL1
Entrez ID		2317	51177
HPRD ID		04543	12217
Ensembl ID		ENSG00000136068	ENSG00000023902
Uniprot IDs		O75369	Q53GL0 Q5T4P9
PDB IDs		2DI8 2DI9 2DIA 2DIB 2DIC 2DJ4 2DLG 2DMB 2DMC 2E9I 2E9J 2EE6 2EE9 2EEA 2EEB 2EEC 2EED 2WA5 2WA6 2WA7 3FER 4B7L 5DCP	3AA1
Enriched GO Terms of Interacting Partners?		Cell-cell Adhesion Cell Adhesion Positive Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Protein Activation Cascade Synaptic Membrane Receptor Complex Integrin Complex Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Cells Formation Of Radial Glial Scaffolds Positive Regulation Of L-glutamate Import Across Plasma Membrane Signal Transduction Ruffle Membrane Glycoprotein Ib-IX-V Complex C-X3-C Chemokine Binding Negative Regulation Of Apoptotic Process Regulation Of Anatomical Structure Morphogenesis Anchoring Junction Negative Regulation Of Programmed Cell Death Negative Regulation Of Multicellular Organismal Process Focal Adhesion Cell Migration Aspartic Endopeptidase Activity, Intramembrane Cleaving Cell Activation Gamma-secretase Complex Platelet Aggregation Blood Coagulation, Intrinsic Pathway Regulation Of L-glutamate Import Across Plasma Membrane Notch Receptor Processing Coreceptor Activity Protein Maturation Amyloid-beta Formation Cell Motility Homotypic Cell-cell Adhesion Regulation Of Tumor Necrosis Factor Production Glutamatergic Synapse Ubiquitin Protein Ligase Activity Positive Regulation Of Platelet Activation Cell Morphogenesis Actin Cytoskeleton Organization Wound Healing Positive Regulation Of Locomotion Neuromuscular Junction Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Mesodermal Cell Differentiation Cell Development Virus Receptor Activity	Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Negative Regulation Of Fatty Acid Transport Positive Regulation Of Translational Initiation Regulation Of Translational Initiation Protein Localization To Membrane Symbiont-mediated Disruption Of Host Cell PML Body Localization Within Membrane Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Fatty Acid Transport Positive Regulation Of Protein Metabolic Process Golgi To Plasma Membrane Protein Transport Regulation Of Glucose Metabolic Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Lipid Transport Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Cellular Localization Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Translational Initiation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Localization Regulation Of Protein Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of D-glucose Import Positive Regulation Of JUN Kinase Activity Regulation Of Lipid Catabolic Process Membrane Golgi To Plasma Membrane Transport Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Translation Negative Regulation Of Transport TORC1 Signaling Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Vacuole Involved In Autophagy Toll-like Receptor 3 Signaling Pathway Myelin Maintenance Pattern Recognition Receptor Signaling Pathway Regulation Of PERK-mediated Unfolded Protein Response
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