ERC1 and DNAJC5

Number of citations of the paper that reports this interaction (PubMedID 29997244)
64

Data Source:
BioGRID (fluorescent resonance energy transfer)

		ERC1	DNAJC5
Description		ELKS/RAB6-interacting/CAST family member 1	DnaJ heat shock protein family (Hsp40) member C5
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Podosome Cytoplasm Golgi Apparatus Centrosome Cytoskeleton Plasma Membrane IkappaB Kinase Complex Membrane Ciliary Basal Body Presynaptic Membrane Cell Projection Synapse Anchoring Junction Presynapse Presynaptic Active Zone Cytoplasmic Component	Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Azurophil Granule Membrane Specific Granule Membrane Melanosome Chromaffin Granule Membrane Intracellular Membrane-bounded Organelle Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Presynapse
	Molecular Function	Protein Binding PDZ Domain Binding Small GTPase Binding Cadherin Binding Structural Constituent Of Presynaptic Active Zone	Protein Binding ATP-dependent Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription I-kappaB Phosphorylation Protein Transport Retrograde Transport, Endosome To Golgi Maintenance Of Presynaptic Active Zone Structure Positive Regulation Of NF-kappaB Transcription Factor Activity	Protein Folding Exocytosis Synaptic Vesicle Exocytosis Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Neuron Apoptotic Process Regulation Of Synaptic Vesicle Cycle
Pathways			Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms) ( 32595297) Body mass index ( 26426971) Femur bone mineral density x serum urate levels interaction ( 34046847) Forehead morphology ( 29921221) Height ( 29782485) Lumbar spine bone mineral density ( 22504420) Medial temporal lobe substructure volumes ( 32768867) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		11 interacting genes: APP DNAJC5 DYRK1A ITSN2 PPFIA1 RAB6A RAB6B RIMS1 SRPK2 UBC YWHAG	49 interacting genes: AGFG1 AP2B1 ARHGEF15 BTC CADM1 CADPS CD2 CFTR CGB5 CLCN3 ERC1 FAS FCHO1 GRM8 HBA2 KHDC4 LIN7A LIN7C NECAP1 NRXN3 PPFIA4 PRKACA PRKCG PRRC2B PSMD12 RABGEF1 RBSN SCAMP3 SCAMP5 SH3GL3 SLC17A8 SLC18A2 SLC30A3 SLC32A1 SNAP29 SNAP91 SNCA STX12 STX3 STX4 STX6 SV2A SYT12 SYT5 SYT9 VAMP1 VAMP3 VAMP4 VAMP7
Entrez ID		23085	80331
HPRD ID		06181	08539
Ensembl ID		ENSG00000082805	ENSG00000101152
Uniprot IDs		G8JLD3 Q8IUD2 X6RLX0 X6RM00	Q9H3Z4
PDB IDs			2N04 2N05
Enriched GO Terms of Interacting Partners?		Presynapse Endosome To Plasma Membrane Transport Vesicle Protein Localization To Golgi Membrane Vesicle-mediated Transport RAGE Receptor Binding Regulation Of Neuron Apoptotic Process Astrocyte Activation Positive Regulation Of Superoxide Anion Generation Myosin V Binding Positive Regulation Of Dendrite Extension Vesicle-mediated Transport In Synapse Regulation Of Modification Of Synaptic Structure Regulation Of Modification Of Postsynaptic Structure Regulation Of Superoxide Anion Generation Positive Regulation Of Monocyte Chemotaxis Protein Localization To Golgi Apparatus Regulation Of Superoxide Metabolic Process Microglial Cell Activation Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Monocyte Chemotaxis Leukocyte Activation Involved In Inflammatory Response Synaptic Vesicle Exocytosis Intra-Golgi Vesicle-mediated Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Histone H3T45 Kinase Activity Peptidyl-cysteine Methylation Protein Methylation Positive Regulation Of Vitamin D 24-hydroxylase Activity Presynaptic Active Zone Positive Chemotaxis Regulation Of Cellular Component Organization Positive Regulation Of ERK1 And ERK2 Cascade Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Modulation Of Excitatory Postsynaptic Potential	Synaptic Vesicle Membrane Vesicle-mediated Transport Synapse SNARE Binding Neurotransmitter Transport SNARE Complex Secretion By Cell Exocytosis Cytoplasmic Vesicle Establishment Of Localization In Cell SNAP Receptor Activity Synaptic Vesicle Secretion Regulation Of Vesicle-mediated Transport Presynapse Protein Transport Regulation Of Exocytosis Plasma Membrane Membrane Establishment Of Protein Localization Organelle Fusion SNARE Complex Assembly Neuron Projection Vesicle Fusion Organelle Membrane Fusion Clathrin-coated Endocytic Vesicle Membrane Vesicle Organization Neurotransmitter Secretion Organelle Localization By Membrane Tethering Regulation Of Regulated Secretory Pathway Phagocytic Vesicle Glutamatergic Synapse Regulation Of Secretion By Cell Organelle Localization Membrane Docking Vesicle-mediated Transport In Synapse Membrane Fusion Regulation Of Secretion Recycling Endosome Membrane Endosome Signal Release Vesicle Docking Intracellular Protein Localization Regulation Of Transport Positive Regulation Of Exocytosis Membrane Organization Regulation Of Endocytosis Chemical Synaptic Transmission Trans-synaptic Signaling Long-term Synaptic Potentiation
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