DNAJC5 and ARHGEF15

Number of citations of the paper that reports this interaction (PubMedID 29997244)
64

Data Source:
BioGRID (fluorescent resonance energy transfer)

		DNAJC5	ARHGEF15
Description		DnaJ heat shock protein family (Hsp40) member C5	Rho guanine nucleotide exchange factor 15
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Azurophil Granule Membrane Specific Granule Membrane Melanosome Chromaffin Granule Membrane Intracellular Membrane-bounded Organelle Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Presynapse	Cytoplasm Cytosol Dendrite Cell Projection Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding ATP-dependent Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Protein Folding Exocytosis Synaptic Vesicle Exocytosis Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Neuron Apoptotic Process Regulation Of Synaptic Vesicle Cycle	Regulation Of Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Retina Vasculature Morphogenesis In Camera-type Eye Regulation Of Postsynapse Assembly Negative Regulation Of Synapse Maturation
Pathways		Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)	Bipolar disorder ( 28115744) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Immature fraction of reticulocytes ( 32888494) LDL cholesterol ( 30275531) Platelet distribution width ( 32888494) Total cholesterol levels ( 30275531) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		49 interacting genes: AGFG1 AP2B1 ARHGEF15 BTC CADM1 CADPS CD2 CFTR CGB5 CLCN3 ERC1 FAS FCHO1 GRM8 HBA2 KHDC4 LIN7A LIN7C NECAP1 NRXN3 PPFIA4 PRKACA PRKCG PRRC2B PSMD12 RABGEF1 RBSN SCAMP3 SCAMP5 SH3GL3 SLC17A8 SLC18A2 SLC30A3 SLC32A1 SNAP29 SNAP91 SNCA STX12 STX3 STX4 STX6 SV2A SYT12 SYT5 SYT9 VAMP1 VAMP3 VAMP4 VAMP7	14 interacting genes: CDC42 CEP55 CSTPP1 DNAJC5 EPHA4 ESR1 ESRRG GORASP2 LASP1 MOB4 PIN1 PRKG1 RHOA SH3RF1
Entrez ID		80331	22899
HPRD ID		08539	10535
Ensembl ID		ENSG00000101152	ENSG00000198844
Uniprot IDs		Q9H3Z4	A0A0S2Z547 O94989
PDB IDs		2N04 2N05
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle Membrane Vesicle-mediated Transport Synapse SNARE Binding Neurotransmitter Transport SNARE Complex Secretion By Cell Exocytosis Cytoplasmic Vesicle Establishment Of Localization In Cell SNAP Receptor Activity Synaptic Vesicle Secretion Regulation Of Vesicle-mediated Transport Presynapse Protein Transport Regulation Of Exocytosis Plasma Membrane Membrane Establishment Of Protein Localization Organelle Fusion SNARE Complex Assembly Neuron Projection Vesicle Fusion Organelle Membrane Fusion Clathrin-coated Endocytic Vesicle Membrane Vesicle Organization Neurotransmitter Secretion Organelle Localization By Membrane Tethering Regulation Of Regulated Secretory Pathway Phagocytic Vesicle Glutamatergic Synapse Regulation Of Secretion By Cell Organelle Localization Membrane Docking Vesicle-mediated Transport In Synapse Membrane Fusion Regulation Of Secretion Recycling Endosome Membrane Endosome Signal Release Vesicle Docking Intracellular Protein Localization Regulation Of Transport Positive Regulation Of Exocytosis Membrane Organization Regulation Of Endocytosis Chemical Synaptic Transmission Trans-synaptic Signaling Long-term Synaptic Potentiation	Postsynapse Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Midbody Steroid Hormone Receptor Signaling Pathway Estrogen Response Element Binding Regulation Of Intracellular Signal Transduction Regulation Of Cytokinesis Glutamatergic Synapse Nuclear Receptor-mediated Signaling Pathway Establishment Of Epithelial Cell Apical/basal Polarity Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Negative Regulation Of Locomotion Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Modification Of Synaptic Structure Polarized Epithelial Cell Differentiation Negative Regulation Of Cell Motility Nuclear Steroid Receptor Activity Microtubule Polymerization Hormone-mediated Signaling Pathway Mitotic Cytokinetic Process Neuron Migration Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Establishment Of Epithelial Cell Polarity Steroid Binding Organelle Organization Negative Regulation Of Neuron Apoptotic Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Division Cell-cell Junction Organization Negative Regulation Of Apoptotic Process Cytokinetic Process Intracellular Signaling Cassette Cell Junction Organization Microtubule Polymerization Or Depolymerization Negative Regulation Of Signal Transduction Cell Migration Negative Regulation Of Programmed Cell Death Supramolecular Fiber Organization Positive Regulation Of Cytokinesis Substantia Nigra Development Regulation Of Amyloid-beta Formation Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Intracellular Receptor Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Stress Fiber Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Mitotic Cleavage Furrow Formation Cytoplasm
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