ERC1 and IFFO1

		ERC1	IFFO1
Description		ELKS/RAB6-interacting/CAST family member 1	intermediate filament family orphan 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Podosome Cytoplasm Golgi Apparatus Centrosome Cytoskeleton Plasma Membrane IkappaB Kinase Complex Membrane Ciliary Basal Body Presynaptic Membrane Cell Projection Synapse Anchoring Junction Presynapse Presynaptic Active Zone Cytoplasmic Component	Nucleus Nuclear Inner Membrane Nucleoplasm Intermediate Filament Membrane Nuclear Matrix Site Of Double-strand Break
	Molecular Function	Protein Binding PDZ Domain Binding Small GTPase Binding Cadherin Binding Structural Constituent Of Presynaptic Active Zone	Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription I-kappaB Phosphorylation Protein Transport Retrograde Transport, Endosome To Golgi Maintenance Of Presynaptic Active Zone Structure Positive Regulation Of NF-kappaB Transcription Factor Activity	Double-strand Break Repair Via Nonhomologous End Joining Protein Localization To Site Of Double-strand Break DNA Double-strand Break Attachment To Nuclear Envelope
Pathways
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms) ( 32595297) Body mass index ( 26426971) Femur bone mineral density x serum urate levels interaction ( 34046847) Forehead morphology ( 29921221) Height ( 29782485) Lumbar spine bone mineral density ( 22504420) Medial temporal lobe substructure volumes ( 32768867) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		11 interacting genes: APP DNAJC5 DYRK1A ITSN2 PPFIA1 RAB6A RAB6B RIMS1 SRPK2 UBC YWHAG	8 interacting genes: ACAP1 GFI1B LMNA NDN RHOU RNF183 TCHP XRCC4
Entrez ID		23085	25900
HPRD ID		06181	09988
Ensembl ID		ENSG00000082805	ENSG00000010295
Uniprot IDs		G8JLD3 Q8IUD2 X6RLX0 X6RM00	A0A087WZ16 B4DQQ1 Q0D2I5 Q6P593
PDB IDs			6ABO
Enriched GO Terms of Interacting Partners?		Presynapse Endosome To Plasma Membrane Transport Vesicle Protein Localization To Golgi Membrane Vesicle-mediated Transport RAGE Receptor Binding Regulation Of Neuron Apoptotic Process Astrocyte Activation Positive Regulation Of Superoxide Anion Generation Myosin V Binding Positive Regulation Of Dendrite Extension Vesicle-mediated Transport In Synapse Regulation Of Modification Of Synaptic Structure Regulation Of Modification Of Postsynaptic Structure Regulation Of Superoxide Anion Generation Positive Regulation Of Monocyte Chemotaxis Protein Localization To Golgi Apparatus Regulation Of Superoxide Metabolic Process Microglial Cell Activation Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Monocyte Chemotaxis Leukocyte Activation Involved In Inflammatory Response Synaptic Vesicle Exocytosis Intra-Golgi Vesicle-mediated Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Histone H3T45 Kinase Activity Peptidyl-cysteine Methylation Protein Methylation Positive Regulation Of Vitamin D 24-hydroxylase Activity Presynaptic Active Zone Positive Chemotaxis Regulation Of Cellular Component Organization Positive Regulation Of ERK1 And ERK2 Cascade Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Modulation Of Excitatory Postsynaptic Potential
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