ERC1 and RAB6A

Number of citations of the paper that reports this interaction (PMID 11929610)
27

Data Source:
HPRD (two hybrid, in vitro)

		ERC1	RAB6A
Gene Name		ELKS/RAB6-interacting/CAST family member 1	RAB6A, member RAS oncogene family
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm IkappaB Kinase Complex Presynaptic Membrane Synapse	Golgi Membrane Golgi Apparatus Trans-Golgi Network Cytosol Membrane Cytoplasmic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Rab GTPase Binding PDZ Domain Binding Leucine Zipper Domain Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Regulation Of Transcription, DNA-templated I-kappaB Phosphorylation Multicellular Organismal Development Protein Transport Retrograde Transport, Endosome To Golgi Positive Regulation Of NF-kappaB Transcription Factor Activity	Protein Targeting To Golgi Retrograde Vesicle-mediated Transport, Golgi To ER Peptidyl-cysteine Methylation Antigen Processing And Presentation Rab Protein Signal Transduction Protein Localization To Golgi Apparatus Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Minus-end-directed Organelle Transport Along Microtubule
Pathways			Pre-NOTCH Processing in Golgi Signaling by NOTCH Pre-NOTCH Expression and Processing
Drugs
Diseases
GWAS		Bone mineral density ( 22504420)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		7 interactors: APP ITSN2 PPFIA1 RAB6A RAB6B RIMS1 YWHAG	20 interactors: BICD1 BICD2 CHM CHML DCTN1 ERC1 FKBP2 GDI1 GOLGA1 GOLGA2 GOLGA4 KIF20A OCRL PMM1 RAB7A RABAC1 RABGAP1 RABGGTB SYTL5 TMF1
Entrez ID		23085	5870
HPRD ID		06181	01543
Ensembl ID		ENSG00000082805	ENSG00000175582
Uniprot IDs		Q8IUD2	P20340 Q53ET8
PDB IDs			1YZQ 2GIL 3BBP 3CWZ 4DKX
Enriched GO Terms of Interacting Partners?		Establishment Of Localization In Cell Cellular Localization Vesicle-mediated Transport Transport Glutamate Secretion Intracellular Transport Retrograde Vesicle-mediated Transport, Golgi To ER Intracellular Protein Transport Intra-Golgi Vesicle-mediated Transport Rab Protein Signal Transduction Acid Secretion Retrograde Transport, Endosome To Golgi Dicarboxylic Acid Transport Secretion By Cell Cellular Protein Localization Protein Transport Neurotransmitter Secretion Establishment Of Protein Localization Synaptic Growth At Neuromuscular Junction Secretion Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Regulation Of Neurotransmitter Levels Collateral Sprouting In Absence Of Injury Minus-end-directed Organelle Transport Along Microtubule Peptidyl-cysteine Methylation Amino Acid Transport Signaling Regulation Of Synaptic Plasticity Neurotransmitter Transport Cell Communication Protein Localization Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Endosomal Transport Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Ras Protein Signal Transduction Axon Choice Point Recognition Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Cellular Localization Golgi Vesicle Transport Negative Regulation Of Stress Fiber Assembly Neuron Remodeling Regulation Of Catalytic Activity Early Endosome To Golgi Transport Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Negative Regulation Of Actin Filament Bundle Assembly	Protein Geranylgeranylation Protein Localization Establishment Of Localization In Cell Intracellular Transport Cellular Localization Protein Prenylation Protein Transport Establishment Of Protein Localization Minus-end-directed Organelle Transport Along Microtubule Cellular Protein Localization Transport Retrograde Transport, Endosome To Golgi Microtubule Anchoring At Microtubule Organizing Center Intracellular Protein Transport Vesicle-mediated Transport Microtubule-based Movement Positive Regulation Of Hydrolase Activity Microtubule-based Transport Protein Targeting To Golgi Cytoskeleton-dependent Intracellular Transport Establishment Of Protein Localization To Golgi Retrograde Transport, Vesicle Recycling Within Golgi Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Protein Targeting Organelle Assembly Protein Localization To Golgi Apparatus Endosomal Transport Protein Localization To Organelle Regulation Of Proteinase Activated Receptor Activity Epidermal Growth Factor Catabolic Process Negative Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Testosterone Secretion Positive Regulation Of Catalytic Activity Organelle Transport Along Microtubule Intra-Golgi Vesicle-mediated Transport Microtubule Anchoring Rab Protein Signal Transduction Regulation Of Catalytic Activity Luteinizing Hormone Secretion Negative Regulation Of Phospholipase C Activity Positive Regulation Of Androgen Secretion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Establishment Of Protein Localization To Organelle Microtubule-based Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Phagosome-lysosome Fusion Phagosome Acidification Negative Regulation Of Protein Targeting To Membrane
Tagcloud ?		betweenness calr calreticulin centrosome chance coagulation colocalized create cytoskeleton ddx3x dengue denv dsrna golga2 interacted mosquito ns3 ns5 occupy overlapping preferentially replication replicon starting throughput transmitted trip11 ube2i vast	autosomal axonal causal coh1 cohen constitutively disability dystrophy golgi gtpase inactive integrity intellectual interfered microcephaly neurite neuritogenesis outgrowth preferentially preparations prevents q72l recessive rnai scaffold solubilization t27n vps13b
Tagcloud (Difference) ?		betweenness calr calreticulin centrosome chance coagulation colocalized create cytoskeleton ddx3x dengue denv dsrna golga2 interacted mosquito ns3 ns5 occupy overlapping replication replicon starting throughput transmitted trip11 ube2i vast	autosomal axonal causal coh1 cohen constitutively disability dystrophy golgi gtpase inactive integrity intellectual interfered microcephaly neurite neuritogenesis outgrowth preparations prevents q72l recessive rnai scaffold solubilization t27n vps13b
Tagcloud (Intersection) ?		preferentially