ERC1 and PPFIA1

Number of citations of the paper that reports this interaction (PMID 12923177)
33

Data Source:
HPRD (in vitro, in vivo)

		ERC1	PPFIA1
Gene Name		ELKS/RAB6-interacting/CAST family member 1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm IkappaB Kinase Complex Presynaptic Membrane Synapse	Cytoplasm Cytosol Focal Adhesion Presynaptic Active Zone
	Molecular Function	Protein Binding Rab GTPase Binding PDZ Domain Binding Leucine Zipper Domain Binding	Signal Transducer Activity Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated I-kappaB Phosphorylation Multicellular Organismal Development Protein Transport Retrograde Transport, Endosome To Golgi Positive Regulation Of NF-kappaB Transcription Factor Activity	Cell-matrix Adhesion Signal Transduction Synaptic Transmission Neurotransmitter Secretion Glutamate Secretion Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane
Pathways			Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Bone mineral density ( 22504420)
Protein-Protein Interactions		7 interactors: APP ITSN2 PPFIA1 RAB6A RAB6B RIMS1 YWHAG	25 interactors: AGTPBP1 CAST CCNH CEP70 DTNB ERC1 ERC2 FAM161A GIT1 MBIP NCOA2 NDN PPFIA2 PPFIA3 PPFIBP1 PPFIBP2 PPP2R5D PTPRC PTPRD PTPRF PTPRG PTPRS TNNT1 TXLNA YWHAG
Entrez ID		23085	8500
HPRD ID		06181	11451
Ensembl ID		ENSG00000082805	ENSG00000131626
Uniprot IDs		Q8IUD2	B3KVS8 Q13136
PDB IDs
Enriched GO Terms of Interacting Partners?		Establishment Of Localization In Cell Cellular Localization Vesicle-mediated Transport Transport Glutamate Secretion Intracellular Transport Retrograde Vesicle-mediated Transport, Golgi To ER Intracellular Protein Transport Intra-Golgi Vesicle-mediated Transport Rab Protein Signal Transduction Acid Secretion Retrograde Transport, Endosome To Golgi Dicarboxylic Acid Transport Secretion By Cell Cellular Protein Localization Protein Transport Neurotransmitter Secretion Establishment Of Protein Localization Synaptic Growth At Neuromuscular Junction Secretion Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Regulation Of Neurotransmitter Levels Collateral Sprouting In Absence Of Injury Minus-end-directed Organelle Transport Along Microtubule Peptidyl-cysteine Methylation Amino Acid Transport Signaling Regulation Of Synaptic Plasticity Neurotransmitter Transport Cell Communication Protein Localization Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Endosomal Transport Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Ras Protein Signal Transduction Axon Choice Point Recognition Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Cellular Localization Golgi Vesicle Transport Negative Regulation Of Stress Fiber Assembly Neuron Remodeling Regulation Of Catalytic Activity Early Endosome To Golgi Transport Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Negative Regulation Of Actin Filament Bundle Assembly	Peptidyl-tyrosine Dephosphorylation Protein Dephosphorylation Dephosphorylation Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Signaling Cell Communication Cell Cycle Phase Transition Nervous System Development G2/M Transition Of Mitotic Cell Cycle Glutamate Secretion Cellular Protein Modification Process Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Transcription Initiation From RNA Polymerase I Promoter Generation Of Neurons Transcription From RNA Polymerase I Promoter Neurogenesis Cell Adhesion Signal Transduction Negative Regulation Of Protein Kinase Activity Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Negative Regulation Of Kinase Activity Acid Secretion Mitotic Cell Cycle Phase Transition Cellular Response To Stimulus Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transferase Activity Phosphate-containing Compound Metabolic Process Dicarboxylic Acid Transport DNA-templated Transcription, Elongation Cellular Protein Metabolic Process Negative Regulation Of Protein Phosphorylation Neuron Differentiation C-terminal Protein Deglutamylation Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Response To Stimulus Neurotransmitter Secretion Cell Surface Receptor Signaling Pathway Developmental Process Histone Acetylation Negative Regulation Of Catalytic Activity Cerebellum Development Regulation Of Kinase Activity Negative Regulation Of Phosphorylation
Tagcloud ?		betweenness calr calreticulin centrosome chance coagulation colocalized create cytoskeleton ddx3x dengue denv dsrna golga2 interacted mosquito ns3 ns5 occupy overlapping preferentially replication replicon starting throughput transmitted trip11 ube2i vast	11q13 aberrations acgh aiming amplicon apart band breakpoints candidates ccnd1 chosen chr comprised copies cttn distinguish fadd gain homogeneously laryngeal microarray oncogene oncogenes oraov1 q13 rearrangements reinvestigated sevenfold ways
Tagcloud (Difference) ?		betweenness calr calreticulin centrosome chance coagulation colocalized create cytoskeleton ddx3x dengue denv dsrna golga2 interacted mosquito ns3 ns5 occupy overlapping preferentially replication replicon starting throughput transmitted trip11 ube2i vast	11q13 aberrations acgh aiming amplicon apart band breakpoints candidates ccnd1 chosen chr comprised copies cttn distinguish fadd gain homogeneously laryngeal microarray oncogene oncogenes oraov1 q13 rearrangements reinvestigated sevenfold ways
Tagcloud (Intersection) ?