DNAJC5 and SLC18A2

Number of citations: 64 (PubMedID 29997244)
Data Source: BioGRID (fluorescent resonance energy transfer)

		DNAJC5	SLC18A2
Name		DnaJ heat shock protein family (Hsp40) member C5	solute carrier family 18 member A2
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Azurophil Granule Membrane Specific Granule Membrane Melanosome Chromaffin Granule Membrane Intracellular Membrane-bounded Organelle Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Presynapse	Centrosome Plasma Membrane Synaptic Vesicle Membrane Axon Dendrite Transport Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Terminal Bouton Synapse Clathrin-sculpted Monoamine Transport Vesicle Membrane Dopaminergic Synapse
	Molecular Function	Protein Binding ATP-dependent Protein Binding	Serotonin:sodium:chloride Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Monoamine:proton Antiporter Activity Transmembrane Transporter Activity
	Biological Process	Protein Folding Exocytosis Synaptic Vesicle Exocytosis Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Neuron Apoptotic Process Regulation Of Synaptic Vesicle Cycle	Response To Amphetamine Serotonin Secretion By Mast Cell Histamine Secretion By Mast Cell Neurotransmitter Transport Serotonin Transport Chemical Synaptic Transmission Locomotory Behavior Response To Toxic Substance Post-embryonic Development Aminergic Neurotransmitter Loading Into Synaptic Vesicle Monoamine Transport Dopamine Transport Serotonin Uptake Histamine Uptake Establishment Of Localization In Cell Transmembrane Transport Neurotransmitter Loading Into Synaptic Vesicle Somato-dendritic Dopamine Secretion Proton Transmembrane Transport Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways		Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle
Drugs		None	Amphetamine Reserpine Norepinephrine Haloperidol Mazindol Benzphetamine Dopamine Deserpidine Ephedra sinica root MMDA Midomafetamine 4-Methoxyamphetamine Dextroamphetamine Metamfetamine Nomifensine Tetrabenazine Histamine Isometheptene Propylhexedrine Serotonin Rauwolfia serpentina root Deutetrabenazine
GWAS		Immature fraction of reticulocytes ( 32888494 ) Mean platelet volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Prostate cancer ( 23535732 )	Body mass index ( 26426971 ) Retinopathy x type 2 diabetes interaction ( 32541925 ) Serum metabolite levels ( 33031748 )
Interacting Genes		49 interacting genes: AGFG1 AP2B1 ARHGEF15 BTC CADM1 CADPS CD2 CFTR CGB5 CLCN3 ERC1 FAS FCHO1 GRM8 HBA2 KHDC4 LIN7A LIN7C NECAP1 NRXN3 PPFIA4 PRKACA PRKCG PRRC2B PSMD12 RABGEF1 RBSN SCAMP3 SCAMP5 SH3GL3 SLC17A8 SLC18A2 SLC30A3 SLC32A1 SNAP29 SNAP91 SNCA STX12 STX3 STX4 STX6 SV2A SYT12 SYT5 SYT9 VAMP1 VAMP3 VAMP4 VAMP7	14 interacting genes: BRICD5 CFHR5 CMTM5 CSNK1A1 CSNK2A1 CSNK2A2 CXCR2 DNAJC5 GPR151 NKG7 SLC61A1 SLC7A1 TMEM109 TOMM6
Entrez ID		80331	6571
HPRD ID		08539	01896
Ensembl ID		ENSG00000101152	ENSG00000165646
Uniprot IDs		Q9H3Z4	Q05940
PDB IDs		2N04 2N05	8JSW 8JSX 8JT5 8JT9 8JTA 8JTB 8JTC 8T69 8T6A 8T6B 8THR 8UCJ 8UCK 8UCL 8UCM 8UCN 8UCO 8UCP 8WLJ 8WLK 8WLL 8WLM 8WRD 8WRE 8WVG 8X3K 8XO9 8XOA 8XOB 9KQ8 9KQA 9KQE
GO Terms Enriched among Interactors		Synaptic Vesicle Membrane Vesicle-mediated Transport Synapse SNARE Binding Neurotransmitter Transport SNARE Complex Secretion By Cell Exocytosis Cytoplasmic Vesicle Establishment Of Localization In Cell SNAP Receptor Activity Synaptic Vesicle Secretion Regulation Of Vesicle-mediated Transport Presynapse Protein Transport Regulation Of Exocytosis Plasma Membrane Membrane Establishment Of Protein Localization Organelle Fusion SNARE Complex Assembly Neuron Projection Vesicle Fusion Organelle Membrane Fusion Clathrin-coated Endocytic Vesicle Membrane Vesicle Organization Neurotransmitter Secretion Organelle Localization By Membrane Tethering Regulation Of Regulated Secretory Pathway Phagocytic Vesicle Glutamatergic Synapse Regulation Of Secretion By Cell Organelle Localization Membrane Docking Vesicle-mediated Transport In Synapse Membrane Fusion Regulation Of Secretion Recycling Endosome Membrane Endosome Signal Release Vesicle Docking Intracellular Protein Localization Regulation Of Transport Positive Regulation Of Exocytosis Membrane Organization Regulation Of Endocytosis Chemical Synaptic Transmission Trans-synaptic Signaling Long-term Synaptic Potentiation	Protein Kinase CK2 Complex Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process PcG Protein Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Molybdate Ion Transmembrane Transporter Activity Molybdate Ion Transport Wnt Signaling Pathway Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Response To Stress Interleukin-8 Receptor Activity Interleukin-8-mediated Signaling Pathway Lysine Transport L-histidine Import Across Plasma Membrane Regulation Of Chromosome Separation