DNAJC5 and LIN7A

Number of citations of the paper that reports this interaction (PubMedID 29997244)
64

Data Source:
BioGRID (fluorescent resonance energy transfer)

		DNAJC5	LIN7A
Description		DnaJ heat shock protein family (Hsp40) member C5	lin-7 cell polarity scaffold A
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Azurophil Granule Membrane Specific Granule Membrane Melanosome Chromaffin Granule Membrane Intracellular Membrane-bounded Organelle Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Presynapse	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Synapse Postsynaptic Membrane Extracellular Exosome Anchoring Junction MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane
	Molecular Function	Protein Binding ATP-dependent Protein Binding	Protein Binding Protein-macromolecule Adaptor Activity L27 Domain Binding
	Biological Process	Protein Folding Exocytosis Synaptic Vesicle Exocytosis Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Neuron Apoptotic Process Regulation Of Synaptic Vesicle Cycle	Exocytosis Neurotransmitter Secretion Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Transport Synaptic Vesicle Transport Inner Ear Development Protein-containing Complex Assembly
Pathways		Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea	Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs
Diseases
GWAS		Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)	Age-related cataracts (age at onset) ( 25352737) Dental caries ( 23259602)
Interacting Genes		49 interacting genes: AGFG1 AP2B1 ARHGEF15 BTC CADM1 CADPS CD2 CFTR CGB5 CLCN3 ERC1 FAS FCHO1 GRM8 HBA2 KHDC4 LIN7A LIN7C NECAP1 NRXN3 PPFIA4 PRKACA PRKCG PRRC2B PSMD12 RABGEF1 RBSN SCAMP3 SCAMP5 SH3GL3 SLC17A8 SLC18A2 SLC30A3 SLC32A1 SNAP29 SNAP91 SNCA STX12 STX3 STX4 STX6 SV2A SYT12 SYT5 SYT9 VAMP1 VAMP3 VAMP4 VAMP7	25 interacting genes: ABCA1 ADGRB1 APP BAIAP2 CASK CHRD DLG2 DLG3 DLG4 DNAJC5 ECM1 FAM9B GOLGA2 GRIN2B KCNJ12 MDFI MPP2 MPP3 MPP7 NOTCH2NLA PALS1 PALS2 SLC6A12 VANGL2 ZYX
Entrez ID		80331	8825
HPRD ID		08539	04542
Ensembl ID		ENSG00000101152	ENSG00000111052
Uniprot IDs		Q9H3Z4	O14910
PDB IDs		2N04 2N05
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle Membrane Vesicle-mediated Transport Synapse SNARE Binding Neurotransmitter Transport SNARE Complex Secretion By Cell Exocytosis Cytoplasmic Vesicle Establishment Of Localization In Cell SNAP Receptor Activity Synaptic Vesicle Secretion Regulation Of Vesicle-mediated Transport Presynapse Protein Transport Regulation Of Exocytosis Plasma Membrane Membrane Establishment Of Protein Localization Organelle Fusion SNARE Complex Assembly Neuron Projection Vesicle Fusion Organelle Membrane Fusion Clathrin-coated Endocytic Vesicle Membrane Vesicle Organization Neurotransmitter Secretion Organelle Localization By Membrane Tethering Regulation Of Regulated Secretory Pathway Phagocytic Vesicle Glutamatergic Synapse Regulation Of Secretion By Cell Organelle Localization Membrane Docking Vesicle-mediated Transport In Synapse Membrane Fusion Regulation Of Secretion Recycling Endosome Membrane Endosome Signal Release Vesicle Docking Intracellular Protein Localization Regulation Of Transport Positive Regulation Of Exocytosis Membrane Organization Regulation Of Endocytosis Chemical Synaptic Transmission Trans-synaptic Signaling Long-term Synaptic Potentiation	Cell-cell Junction Adherens Junction Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Excitatory Postsynaptic Potential Protein Localization To Cell Junction Plasma Membrane Regulation Of Synaptic Plasticity Postsynaptic Density Membrane Modulation Of Excitatory Postsynaptic Potential Basolateral Plasma Membrane Postsynaptic Density Protein Localization To Synapse Synaptic Membrane Dendritic Spine Modulation Of Chemical Synaptic Transmission Neuromuscular Junction PDZ Domain Binding Cellular Component Assembly Neuron Projection Protein Tetramerization Ionotropic Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Binding Presynapse Organelle Cell Adhesion Regulation Of Nervous System Process Dendritic Shaft Protein Complex Oligomerization Ligand-gated Ion Channel Signaling Pathway NMDA Selective Glutamate Receptor Signaling Pathway Cell Projection Receptor Localization To Synapse Receptor Clustering Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission Regulation Of Synapse Organization GMP Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Neuronal Synaptic Plasticity Chemical Synaptic Transmission Intracellular Protein Localization Trans-synaptic Signaling GDP Metabolic Process Synaptic Signaling Juxtaparanode Region Of Axon Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Acetylcholine Receptor Binding
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