ERC1

Description		ELKS/RAB6-interacting/CAST family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Podosome Cytoplasm Golgi Apparatus Centrosome Cytoskeleton Plasma Membrane IkappaB Kinase Complex Membrane Ciliary Basal Body Presynaptic Membrane Cell Projection Synapse Anchoring Junction Presynapse Presynaptic Active Zone Cytoplasmic Component
	Molecular Function	Protein Binding PDZ Domain Binding Small GTPase Binding Cadherin Binding Structural Constituent Of Presynaptic Active Zone
	Biological Process	Regulation Of DNA-templated Transcription I-kappaB Phosphorylation Protein Transport Retrograde Transport, Endosome To Golgi Maintenance Of Presynaptic Active Zone Structure Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms) ( 32595297) Body mass index ( 26426971) Femur bone mineral density x serum urate levels interaction ( 34046847) Forehead morphology ( 29921221) Height ( 29782485) Lumbar spine bone mineral density ( 22504420) Medial temporal lobe substructure volumes ( 32768867) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		10 novel interacting genes: CD163 CRIP1 FGF23 FPR2 GALNT8 GPRC5D IFFO1 MRTFB NCAPD2 PRMT8
Interacting Genes		11 interacting genes: APP DNAJC5 DYRK1A ITSN2 PPFIA1 RAB6A RAB6B RIMS1 SRPK2 UBC YWHAG
Entrez ID		23085
HPRD ID		06181
Ensembl ID		ENSG00000082805
Uniprot IDs		G8JLD3 Q8IUD2 X6RLX0 X6RM00
PDB IDs
Enriched GO Terms of Interacting Partners?		Presynapse Endosome To Plasma Membrane Transport Vesicle Protein Localization To Golgi Membrane Vesicle-mediated Transport RAGE Receptor Binding Regulation Of Neuron Apoptotic Process Astrocyte Activation Positive Regulation Of Superoxide Anion Generation Myosin V Binding Positive Regulation Of Dendrite Extension Vesicle-mediated Transport In Synapse Regulation Of Modification Of Synaptic Structure Regulation Of Modification Of Postsynaptic Structure Regulation Of Superoxide Anion Generation Positive Regulation Of Monocyte Chemotaxis Protein Localization To Golgi Apparatus Regulation Of Superoxide Metabolic Process Microglial Cell Activation Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Monocyte Chemotaxis Leukocyte Activation Involved In Inflammatory Response Synaptic Vesicle Exocytosis Intra-Golgi Vesicle-mediated Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Histone H3T45 Kinase Activity Peptidyl-cysteine Methylation Protein Methylation Positive Regulation Of Vitamin D 24-hydroxylase Activity Presynaptic Active Zone Positive Chemotaxis Regulation Of Cellular Component Organization Positive Regulation Of ERK1 And ERK2 Cascade Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Modulation Of Excitatory Postsynaptic Potential
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