ERC1 and CD163

		ERC1	CD163
Description		ELKS/RAB6-interacting/CAST family member 1	CD163 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Podosome Cytoplasm Golgi Apparatus Centrosome Cytoskeleton Plasma Membrane IkappaB Kinase Complex Membrane Ciliary Basal Body Presynaptic Membrane Cell Projection Synapse Anchoring Junction Presynapse Presynaptic Active Zone Cytoplasmic Component	Extracellular Region Cytoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Membrane Endocytic Vesicle Membrane
	Molecular Function	Protein Binding PDZ Domain Binding Small GTPase Binding Cadherin Binding Structural Constituent Of Presynaptic Active Zone	Scavenger Receptor Activity Protein Binding Scaffold Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription I-kappaB Phosphorylation Protein Transport Retrograde Transport, Endosome To Golgi Maintenance Of Presynaptic Active Zone Structure Positive Regulation Of NF-kappaB Transcription Factor Activity	Acute-phase Response Inflammatory Response Vesicle-mediated Transport
Pathways			Scavenging of heme from plasma CD163 mediating an anti-inflammatory response
Drugs			Tetrachlorodecaoxide
Diseases
GWAS		Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms) ( 32595297) Body mass index ( 26426971) Femur bone mineral density x serum urate levels interaction ( 34046847) Forehead morphology ( 29921221) Height ( 29782485) Lumbar spine bone mineral density ( 22504420) Medial temporal lobe substructure volumes ( 32768867) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Creatine kinase levels ( 29403010) HDL cholesterol levels ( 28334899) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 29083408)
Interacting Genes		11 interacting genes: APP DNAJC5 DYRK1A ITSN2 PPFIA1 RAB6A RAB6B RIMS1 SRPK2 UBC YWHAG	6 interacting genes: CSNK2B FCGR1A HOXA1 HP MYH9 PRKCA
Entrez ID		23085	9332
HPRD ID		06181	05708
Ensembl ID		ENSG00000082805	ENSG00000177575
Uniprot IDs		G8JLD3 Q8IUD2 X6RLX0 X6RM00	C9JHR8 Q86VB7
PDB IDs			8XMK 8XMP 8XMQ 8XMW 9FHB 9FMU 9FNO
Enriched GO Terms of Interacting Partners?		Presynapse Endosome To Plasma Membrane Transport Vesicle Protein Localization To Golgi Membrane Vesicle-mediated Transport RAGE Receptor Binding Regulation Of Neuron Apoptotic Process Astrocyte Activation Positive Regulation Of Superoxide Anion Generation Myosin V Binding Positive Regulation Of Dendrite Extension Vesicle-mediated Transport In Synapse Regulation Of Modification Of Synaptic Structure Regulation Of Modification Of Postsynaptic Structure Regulation Of Superoxide Anion Generation Positive Regulation Of Monocyte Chemotaxis Protein Localization To Golgi Apparatus Regulation Of Superoxide Metabolic Process Microglial Cell Activation Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Monocyte Chemotaxis Leukocyte Activation Involved In Inflammatory Response Synaptic Vesicle Exocytosis Intra-Golgi Vesicle-mediated Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Histone H3T45 Kinase Activity Peptidyl-cysteine Methylation Protein Methylation Positive Regulation Of Vitamin D 24-hydroxylase Activity Presynaptic Active Zone Positive Chemotaxis Regulation Of Cellular Component Organization Positive Regulation Of ERK1 And ERK2 Cascade Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Modulation Of Excitatory Postsynaptic Potential	Phosphorylation Protein Kinase CK2 Complex Protein Phosphorylation Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Phagocytosis, Engulfment Membrane Invagination High-affinity IgG Receptor Activity Acute Inflammatory Response Positive Regulation Of Type III Hypersensitivity Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior Negative Regulation Of Hydrogen Peroxide Catabolic Process Uropod Organization Myosin II Filament Cortical Granule Exocytosis Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex I-kappaB Phosphorylation Anatomical Structure Morphogenesis Positive Regulation Of Type IIa Hypersensitivity Integrin Binding Actomyosin Contractile Ring Protein Kinase C Signaling Membrane Organization Release From Viral Latency Hemoglobin Binding Response To Reactive Oxygen Species Cortical Granule Cytoplasmic Actin-based Contraction Involved In Cell Motility Regulation Of Angiotensin-activated Signaling Pathway Protein Metabolic Process Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle IgG Receptor Activity Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Endothelial Cell Migration Adiponectin-activated Signaling Pathway Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Antibody-dependent Cellular Cytotoxicity Anatomical Structure Formation Involved In Morphogenesis
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