DNAJC5 and SNAP91

Number of citations: 64 (PubMedID 29997244)
Data Source: BioGRID (fluorescent resonance energy transfer)

		DNAJC5	SNAP91
Name		DnaJ heat shock protein family (Hsp40) member C5	synaptosome associated protein 91
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Azurophil Granule Membrane Specific Granule Membrane Melanosome Chromaffin Granule Membrane Intracellular Membrane-bounded Organelle Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Presynapse	Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Membrane Clathrin-coated Vesicle Extrinsic Component Of Presynaptic Endocytic Zone Membrane
	Molecular Function	Protein Binding ATP-dependent Protein Binding	SNARE Binding Protein Binding Phospholipid Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein Kinase Binding Clathrin Binding Clathrin Heavy Chain Binding
	Biological Process	Protein Folding Exocytosis Synaptic Vesicle Exocytosis Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Neuron Apoptotic Process Regulation Of Synaptic Vesicle Cycle	Vesicle Budding From Membrane Protein Transport Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Clathrin-dependent Endocytosis Regulation Of Clathrin-dependent Endocytosis
Pathways		Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
GWAS		Immature fraction of reticulocytes ( 32888494 ) Mean platelet volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Prostate cancer ( 23535732 )	Age-related hearing impairment ( 34108613 ) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 31043756 ) Bipolar disorder with mood-incongruent psychosis ( 23092984 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Electrodermal activity ( 25387706 ) Macular thickness ( 30535121 ) Refractive error ( 32231278 ) Schizophrenia ( 28991256 29483656 30285260 )
Interacting Genes		49 interacting genes: AGFG1 AP2B1 ARHGEF15 BTC CADM1 CADPS CD2 CFTR CGB5 CLCN3 ERC1 FAS FCHO1 GRM8 HBA2 KHDC4 LIN7A LIN7C NECAP1 NRXN3 PPFIA4 PRKACA PRKCG PRRC2B PSMD12 RABGEF1 RBSN SCAMP3 SCAMP5 SH3GL3 SLC17A8 SLC18A2 SLC30A3 SLC32A1 SNAP29 SNAP91 SNCA STX12 STX3 STX4 STX6 SV2A SYT12 SYT5 SYT9 VAMP1 VAMP3 VAMP4 VAMP7	15 interacting genes: ABI2 AP2A2 AP2B1 DNAJC5 EPS15 ERBB2 ERBB3 ERBB4 GEM MIPOL1 NECAP1 OGT PLCG1 TRAF3IP1 TUBA1B
Entrez ID		80331	9892
HPRD ID		08539	06391
Ensembl ID		ENSG00000101152	ENSG00000065609
Uniprot IDs		Q9H3Z4	B7Z2N2 E9PDG8 O60641
PDB IDs		2N04 2N05	Not available
GO Terms Enriched among Interactors		Synaptic Vesicle Membrane Vesicle-mediated Transport Synapse SNARE Binding Neurotransmitter Transport SNARE Complex Secretion By Cell Exocytosis Cytoplasmic Vesicle Establishment Of Localization In Cell SNAP Receptor Activity Synaptic Vesicle Secretion Regulation Of Vesicle-mediated Transport Presynapse Protein Transport Regulation Of Exocytosis Plasma Membrane Membrane Establishment Of Protein Localization Organelle Fusion SNARE Complex Assembly Neuron Projection Vesicle Fusion Organelle Membrane Fusion Clathrin-coated Endocytic Vesicle Membrane Vesicle Organization Neurotransmitter Secretion Organelle Localization By Membrane Tethering Regulation Of Regulated Secretory Pathway Phagocytic Vesicle Glutamatergic Synapse Regulation Of Secretion By Cell Organelle Localization Membrane Docking Vesicle-mediated Transport In Synapse Membrane Fusion Regulation Of Secretion Recycling Endosome Membrane Endosome Signal Release Vesicle Docking Intracellular Protein Localization Regulation Of Transport Positive Regulation Of Exocytosis Membrane Organization Regulation Of Endocytosis Chemical Synaptic Transmission Trans-synaptic Signaling Long-term Synaptic Potentiation	Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Postsynaptic Neurotransmitter Receptor Internalization Vesicle-mediated Transport In Synapse AP-2 Adaptor Complex Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Clathrin-coated Pit ERBB3:ERBB2 Complex ERBB Signaling Pathway ERBB2 Signaling Pathway Neuregulin Receptor Activity ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Presynaptic Endocytosis Cellular Response To Epidermal Growth Factor Stimulus Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Postsynaptic Endocytic Zone ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Receptor Internalization Clathrin Adaptor Complex Neuromuscular Junction Clathrin Adaptor Activity Endolysosome Membrane Heart Development Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Post-anal Tail Morphogenesis Cytoplasmic Side Of Plasma Membrane Clathrin Coat Assembly Clathrin-coated Endocytic Vesicle Protein Tyrosine Kinase Activity Peripheral Nervous System Development Membrane Coat Clathrin-dependent Endocytosis Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Regulation Of Epithelial Cell Proliferation Cellular Localization Establishment Of Localization In Cell Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Endocytosis Growth Factor Binding Receptor Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Establishment Of Planar Polarity Involved In Nephron Morphogenesis