DNAJC5 and SLC32A1

Number of citations of the paper that reports this interaction (PubMedID 29997244)
64

Data Source:
BioGRID (fluorescent resonance energy transfer, affinity chromatography technology, imaging technique)

		DNAJC5	SLC32A1
Description		DnaJ heat shock protein family (Hsp40) member C5	solute carrier family 32 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Azurophil Granule Membrane Specific Granule Membrane Melanosome Chromaffin Granule Membrane Intracellular Membrane-bounded Organelle Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Presynapse	Plasma Membrane Synaptic Vesicle Cell Surface Membrane Dendrite Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Neuron Projection Dendrite Terminus Neuron Projection Terminus Cone Cell Pedicle Synapse Presynaptic Active Zone Cell Tip Inhibitory Synapse Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Presynapse GABA-ergic Synapse
	Molecular Function	Protein Binding ATP-dependent Protein Binding	Amino Acid Transmembrane Transporter Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Glycine Transmembrane Transporter Activity Gamma-aminobutyric Acid:proton Symporter Activity Glycine:proton Antiporter Activity Gamma-aminobutyric Acid:proton Antiporter Activity
	Biological Process	Protein Folding Exocytosis Synaptic Vesicle Exocytosis Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Neuron Apoptotic Process Regulation Of Synaptic Vesicle Cycle	Beta-alanine Transport Amino Acid Transmembrane Transport Monoatomic Ion Transport Neurotransmitter Transport Neurotransmitter Secretion Gamma-aminobutyric Acid Transport Glycine Transport Hippocampus Development Gamma-aminobutyric Acid Import Neurotransmitter Loading Into Synaptic Vesicle Proton Transmembrane Transport
Pathways		Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea	SLC-mediated transport of neurotransmitters GABA synthesis, release, reuptake and degradation
Drugs
Diseases
GWAS		Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)	circulating leptin levels ( 26833098) circulating leptin levels adjusted for BMI ( 26833098) Schizophrenia ( 25056061 29483656)
Interacting Genes		49 interacting genes: AGFG1 AP2B1 ARHGEF15 BTC CADM1 CADPS CD2 CFTR CGB5 CLCN3 ERC1 FAS FCHO1 GRM8 HBA2 KHDC4 LIN7A LIN7C NECAP1 NRXN3 PPFIA4 PRKACA PRKCG PRRC2B PSMD12 RABGEF1 RBSN SCAMP3 SCAMP5 SH3GL3 SLC17A8 SLC18A2 SLC30A3 SLC32A1 SNAP29 SNAP91 SNCA STX12 STX3 STX4 STX6 SV2A SYT12 SYT5 SYT9 VAMP1 VAMP3 VAMP4 VAMP7	2 interacting genes: DNAJC5 F2RL1
Entrez ID		80331	140679
HPRD ID		08539	18058
Ensembl ID		ENSG00000101152	ENSG00000101438
Uniprot IDs		Q9H3Z4	Q9H598
PDB IDs		2N04 2N05
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle Membrane Vesicle-mediated Transport Synapse SNARE Binding Neurotransmitter Transport SNARE Complex Secretion By Cell Exocytosis Cytoplasmic Vesicle Establishment Of Localization In Cell SNAP Receptor Activity Synaptic Vesicle Secretion Regulation Of Vesicle-mediated Transport Presynapse Protein Transport Regulation Of Exocytosis Plasma Membrane Membrane Establishment Of Protein Localization Organelle Fusion SNARE Complex Assembly Neuron Projection Vesicle Fusion Organelle Membrane Fusion Clathrin-coated Endocytic Vesicle Membrane Vesicle Organization Neurotransmitter Secretion Organelle Localization By Membrane Tethering Regulation Of Regulated Secretory Pathway Phagocytic Vesicle Glutamatergic Synapse Regulation Of Secretion By Cell Organelle Localization Membrane Docking Vesicle-mediated Transport In Synapse Membrane Fusion Regulation Of Secretion Recycling Endosome Membrane Endosome Signal Release Vesicle Docking Intracellular Protein Localization Regulation Of Transport Positive Regulation Of Exocytosis Membrane Organization Regulation Of Endocytosis Chemical Synaptic Transmission Trans-synaptic Signaling Long-term Synaptic Potentiation	Proteinase-activated Receptor Activity Positive Regulation Of Glomerular Filtration Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Killing Of Cells Of Another Organism Mature Conventional Dendritic Cell Differentiation Thrombin-activated Receptor Activity Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Positive Regulation Of Toll-like Receptor 2 Signaling Pathway ATP-dependent Protein Binding Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Chromaffin Granule Membrane Regulation Of Vesicle-mediated Transport Regulation Of Toll-like Receptor 3 Signaling Pathway Thrombin-activated Receptor Signaling Pathway Positive Regulation Of Defense Response To Bacterium Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Glomerular Filtration Regulation Of Synaptic Vesicle Cycle Regulation Of Defense Response To Bacterium Pseudopodium Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Protein Depolymerization Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Superoxide Anion Generation Cell-cell Junction Maintenance Positive Regulation Of Superoxide Anion Generation G-protein Beta-subunit Binding Positive Regulation Of Positive Chemotaxis Positive Regulation Of Rho Protein Signal Transduction Negative Regulation Of Chemokine Production Neutrophil Activation G-protein Alpha-subunit Binding Regulation Of Superoxide Metabolic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Synaptic Vesicle Exocytosis Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of JNK Cascade Positive Regulation Of Protein-containing Complex Disassembly Establishment Of Endothelial Barrier Dendritic Cell Differentiation Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway
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