MYCBP2 and EDNRB

		MYCBP2	EDNRB
Description		MYC binding protein 2	endothelin receptor type B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Axon Cell Projection	Plasma Membrane Membrane Nuclear Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Transferase Activity Small GTPase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	G Protein-coupled Receptor Activity Endothelin Receptor Activity Protein Binding Peptide Hormone Binding Type 1 Angiotensin Receptor Binding
	Biological Process	Axon Guidance Motor Neuron Axon Guidance Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Ubiquitination Branchiomotor Neuron Axon Guidance Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of Protein Ubiquitination Regulation Of Protein Localization Circadian Regulation Of Gene Expression Negative Regulation Of Protein Catabolic Process Rhythmic Process Cell Morphogenesis Involved In Neuron Differentiation Neuromuscular Process Regulation Of Cytoskeleton Organization Axon Development Protein K48-linked Ubiquitination Regulation Of Axon Guidance	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Renin Secretion Into Blood Stream Regulation Of Heart Rate Regulation Of PH Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Nervous System Development Peripheral Nervous System Development Posterior Midgut Development Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Gene Expression Negative Regulation Of Neuron Maturation Vein Smooth Muscle Contraction Vascular Associated Smooth Muscle Contraction Calcium-mediated Signaling CGMP-mediated Signaling Heparin Proteoglycan Metabolic Process Melanocyte Differentiation Regulation Of Fever Generation Aldosterone Metabolic Process Response To Lipopolysaccharide Enteric Smooth Muscle Cell Differentiation Positive Regulation Of Urine Volume Renal Sodium Excretion Epithelial Fluid Transport Vasoconstriction Vasodilation Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Pigmentation Developmental Pigmentation Macrophage Chemotaxis Response To Pain Enteric Nervous System Development Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Metabolic Process Sodium Ion Homeostasis Canonical Wnt Signaling Pathway Positive Regulation Of Penile Erection Establishment Of Endothelial Barrier Renal Sodium Ion Absorption Calcium Ion Transmembrane Transport Cellular Response To Lipopolysaccharide Protein Transmembrane Transport Podocyte Differentiation Endothelin Receptor Signaling Pathway Renal Albumin Absorption Neuroblast Migration Chordate Pharynx Development Response To Sodium Phosphate Response To Endothelin
Pathways			Peptide ligand-binding receptors G alpha (q) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Bosentan IRL-1620 Sitaxentan Ambrisentan Enrasentan Tezosentan Macitentan
Diseases			Hirschsprung disease (HD) Waardenburg syndrome (WS) ABCD syndrome Nasopharyngeal cancer
GWAS		Chronotype ( 30696823) Iris heterochromicity ( 30895295) Morning person ( 30696823) Preeclampsia ( 23551011) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)	Appendicular lean mass ( 33097823) Craniofacial microsomia ( 26853712) Hair color ( 23548203 29662168) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		50 interacting genes: AATF APPL1 ARL6IP5 ASB8 ATP13A2 BTG3 CALM1 CD81 CEBPA CFL1 CUEDC2 DHRS4L2 DSCR9 DYRK1A ERBB3 FHL3 FSCN1 HSP90AB1 HUNK IGFBP6 LCOR LDHB LSM14A MYC NDUFB9 NMNAT2 OAZ1 PABPN1 PI4KB PRXL2A PTPN12 PUF60 RGPD8 RPS5 RSPH1 SERPINB6 SOD1 SPARCL1 SPRYD3 SRPK2 TBC1D9 TBC1D9B TBR1 TTN UBE2D2 UBE2D3 UBE2L3 UCHL1 YWHAG YWHAQ	7 interacting genes: CAV1 EDN1 EDN3 GNA11 GNA13 GRK6 NOS3
Entrez ID		23077	1910
HPRD ID		10104	08834
Ensembl ID		ENSG00000005810	ENSG00000136160
Uniprot IDs		O75592	P24530
PDB IDs		5O6C 6T7F	5GLH 5GLI 5X93 5XPR 6IGK 6IGL 6LRY 8HBD 8HCX 8IY5 8IY6 8XGR 8XVE 8XVH 8XWP 8XWQ 8ZRT
Enriched GO Terms of Interacting Partners?		Cytoplasm Intracellular Signal Transduction	Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Blood Pressure Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Blood Vessel Diameter Maintenance Vasoconstriction Regulation Of Tube Size Endothelin B Receptor Binding Regulation Of Systemic Arterial Blood Pressure Vein Smooth Muscle Contraction Regulation Of Heart Contraction Regulation Of Locomotion Regulation Of Smooth Muscle Contraction Regulation Of Vasoconstriction Regulation Of Muscle System Process Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Blood Circulation Regulation Of Blood Coagulation Vascular Process In Circulatory System Regulation Of Hemostasis Regulation Of Potassium Ion Transport Regulation Of Developmental Process Circulatory System Process Artery Smooth Muscle Contraction G Protein-coupled Receptor Signaling Pathway Tonic Smooth Muscle Contraction Regulation Of Heart Rate Endothelin Receptor Signaling Pathway Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transport Vascular Associated Smooth Muscle Contraction Guanyl Nucleotide Binding Regulation Of Wound Healing Regulation Of Cell Migration Positive Regulation Of Hormone Secretion Regulation Of Cell Motility Nitric Oxide Biosynthetic Process G-protein Beta/gamma-subunit Complex Binding Regulation Of Muscle Contraction Regulation Of Response To Wounding Regulation Of The Force Of Heart Contraction Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Cell Migration Regulation Of System Process Intracellular Calcium Ion Homeostasis Positive Regulation Of Heart Rate Negative Regulation Of Potassium Ion Transport Positive Regulation Of Cell Motility Nitric Oxide Metabolic Process Positive Regulation Of Smooth Muscle Contraction
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