THRA and RXRB

Number of citations of the paper that reports this interaction (PMID 1331778)
28

Data Source:
HPRD (in vitro)

		THRA	RXRB
Gene Name		thyroid hormone receptor, alpha	retinoid X receptor, beta
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm
	Molecular Function	Steroid Receptor RNA Activator RNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Thyroid Hormone Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding TBP-class Protein Binding Protein Domain Specific Binding Chromatin DNA Binding Protein Complex Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Thyroid Hormone Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity 9-cis Retinoic Acid Receptor Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity
	Biological Process	Cartilage Condensation Ossification Regulation Of Thyroid Hormone Mediated Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Learning Or Memory Regulation Of Heart Contraction Female Courtship Behavior Response To Cold Hormone-mediated Signaling Pathway Gene Expression Positive Regulation Of Myotube Differentiation Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Erythrocyte Differentiation Intracellular Receptor Signaling Pathway Thyroid Gland Development Regulation Of Myeloid Cell Apoptotic Process Cytoplasmic Sequestering Of Transcription Factor Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Female Receptivity Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Catabolic Process Type I Pneumocyte Differentiation Negative Regulation Of DNA-templated Transcription, Initiation	In Utero Embryonic Development Maternal Placenta Development Transcription Initiation From RNA Polymerase II Promoter Gene Expression Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Retinoic Acid Receptor Signaling Pathway Ventricular Cardiac Muscle Cell Differentiation Transmembrane Transport Cardiac Muscle Cell Proliferation Cellular Response To Retinoic Acid
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	Generic Transcription Pathway Signaling by Retinoic Acid Nuclear Receptor transcription pathway Orphan transporters
Drugs		Liothyronine Levothyroxine Dextrothyroxine Liotrix 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid	Adapalene Bexarotene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate 6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic Acid N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE N-(TERT-BUTYL)-3,5-DIMETHYL-N\'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID
Diseases
GWAS		White blood cell count ( 21738480)	Wegener's granulomatosis ( 23740775)
Protein-Protein Interactions		56 interactors: AKAP13 AMOTL2 ARID5A BTG1 BUB3 C1D CCND1 CDK7 CLIC1 COPS2 CREB1 CREBBP CUL1 DAP3 ESR1 FOXJ1 FUS GRIP1 GTF2B HDAC2 HDAC3 ITGB3BP L3MBTL3 MED1 MED21 MED25 MEF2A NCOA1 NCOA6 NCOR1 NCOR2 NR0B2 NR2F1 NRIP1 NSD1 OASL PML POU2F1 PRKDC PTGES3 RANBP9 RGN RXRA RXRB RXRG SEPP1 SLC16A2 SRC SUV39H1 TBL1X TDG TRIM24 TRIP11 YWHAH YWHAQ ZBTB3	32 interactors: AKAP13 CACNA1B GRIP1 GTF2H1 MAP4 MED1 NCOA1 NCOA3 NR0B2 NR1H2 NR1H3 NR1I2 NR2C2 NR2E3 NR3C1 NR4A2 NRIP1 PPARD PPARG PTMS RARA RARB RARG SPOP SRA1 SRC TACC2 TAF11 THRA THRB VDR ZDHHC12
Entrez ID		7067	6257
HPRD ID		07185	01578
Ensembl ID		ENSG00000126351	ENSG00000204231
Uniprot IDs		P10827 Q6FH41	E9PK95 P28702 Q5STP9
PDB IDs		1NAV 2H77 2H79 3HZF 3ILZ 3JZB	1H9U 1UHL
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Rhythmic Process Organ Development Multicellular Organismal Development Regulation Of Cellular Process Anatomical Structure Development Developmental Process Cellular Response To Organic Substance Signal Transduction Chromosome Organization Signaling System Development	Intracellular Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus DNA-templated Transcription, Initiation Cellular Response To Hormone Stimulus Response To Steroid Hormone Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Response To Hormone Positive Regulation Of Cellular Biosynthetic Process Response To Lipid Response To Organic Cyclic Compound Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Response To Organic Substance Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Death
Tagcloud ?		accounts averages bimodality bxd bxh chr counted encode ganglion heritable hoxb idea inbred krt1 lod mapped neuregulin nnc1 opposed qtl qtls retina retinal striking subsidiary surprisingly thyroxine trait vertebrate	2riibp aa acceptor bands cdnas coding cpg deduced designated exons extra finger heterodimers intron island isoforms midst mrxr northern phylogenic spleen spliced splicing superfamily transactivation transcribed twofold zinc
Tagcloud (Difference) ?		accounts averages bimodality bxd bxh chr counted encode ganglion heritable hoxb idea inbred krt1 lod mapped neuregulin nnc1 opposed qtl qtls retina retinal striking subsidiary surprisingly thyroxine trait vertebrate	2riibp aa acceptor bands cdnas coding cpg deduced designated exons extra finger heterodimers intron island isoforms midst mrxr northern phylogenic spleen spliced splicing superfamily transactivation transcribed twofold zinc
Tagcloud (Intersection) ?