THRA and CREB1

Number of citations of the paper that reports this interaction (PMID 12805224)
15

Data Source:
HPRD (in vivo, in vitro)

		THRA	CREB1
Gene Name		thyroid hormone receptor, alpha	cAMP responsive element binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Nuclear Euchromatin ATF1-ATF4 Transcription Factor Complex
	Molecular Function	Steroid Receptor RNA Activator RNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Thyroid Hormone Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding TBP-class Protein Binding Protein Domain Specific Binding Chromatin DNA Binding Protein Complex Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Thyroid Hormone Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Protein Binding Enzyme Binding CAMP Response Element Binding
	Biological Process	Cartilage Condensation Ossification Regulation Of Thyroid Hormone Mediated Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Learning Or Memory Regulation Of Heart Contraction Female Courtship Behavior Response To Cold Hormone-mediated Signaling Pathway Gene Expression Positive Regulation Of Myotube Differentiation Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Erythrocyte Differentiation Intracellular Receptor Signaling Pathway Thyroid Gland Development Regulation Of Myeloid Cell Apoptotic Process Cytoplasmic Sequestering Of Transcription Factor Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Female Receptivity Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Catabolic Process Type I Pneumocyte Differentiation Negative Regulation Of DNA-templated Transcription, Initiation	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Protein Phosphorylation Organelle Organization Mitochondrion Organization Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Notch Signaling Pathway Synaptic Transmission Axon Guidance Lactation Memory Circadian Rhythm Regulation Of Cell Size Fibroblast Growth Factor Receptor Signaling Pathway Response To Organic Substance Negative Regulation Of Transcription By Competitive Promoter Binding Viral Process Pituitary Gland Development Secretory Granule Organization Response To Glucagon Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Multicellular Organism Growth Response To Drug Innate Immune Response Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hormone Secretion Positive Regulation Of Lipid Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Protein Stabilization Stress-activated MAPK Cascade Lung Saccule Development Type I Pneumocyte Differentiation Cellular Response To Zinc Ion
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	Signaling by the B Cell Receptor (BCR) Ca-dependent events Signaling by GPCR CaM pathway Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer CREB phosphorylation through the activation of Ras PLCG1 events in ERBB2 signaling NOTCH2 intracellular domain regulates transcription Signaling by SCF-KIT Toll Like Receptor TLR1:TLR2 Cascade Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Signaling by NOTCH2 PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Signaling by PDGF Calmodulin induced events CaMK IV-mediated phosphorylation of CREB DAP12 interactions PKA-mediated phosphorylation of CREB GAB1 signalosome Signaling by NOTCH TRIF-mediated TLR3/TLR4 signaling Opioid Signalling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling CREB phosphorylation through the activation of Adenylate Cyclase EGFR interacts with phospholipase C-gamma CaMK IV-mediated phosphorylation of CREB Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 PKA-mediated phosphorylation of CREB Signaling by EGFR CREB phosphorylation through the activation of CaMKK AKT phosphorylates targets in the nucleus Calmodulin induced events Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction CREB phosphorylation through the activation of CaMKII Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Transcriptional activation of mitochondrial biogenesis Transmission across Chemical Synapses Adaptive Immune System Organelle biogenesis and maintenance CREB phosphorylation Axon guidance PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade CREB phosphorylation DAG and IP3 signaling Toll Like Receptor TLR6:TLR2 Cascade CaM pathway Activated TLR4 signalling MyD88 cascade initiated on plasma membrane PI3K events in ERBB2 signaling Activation of NMDA receptor upon glutamate binding and postsynaptic events Downstream signaling of activated FGFR MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Post NMDA receptor activation events Innate Immune System Signalling by NGF PLC beta mediated events MAP kinase activation in TLR cascade Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer Mitochondrial biogenesis Signaling by FGFR Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade PLC-gamma1 signalling MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs		Liothyronine Levothyroxine Dextrothyroxine Liotrix 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid	Adenosine monophosphate Naloxone
Diseases
GWAS		White blood cell count ( 21738480)
Protein-Protein Interactions		56 interactors: AKAP13 AMOTL2 ARID5A BTG1 BUB3 C1D CCND1 CDK7 CLIC1 COPS2 CREB1 CREBBP CUL1 DAP3 ESR1 FOXJ1 FUS GRIP1 GTF2B HDAC2 HDAC3 ITGB3BP L3MBTL3 MED1 MED21 MED25 MEF2A NCOA1 NCOA6 NCOR1 NCOR2 NR0B2 NR2F1 NRIP1 NSD1 OASL PML POU2F1 PRKDC PTGES3 RANBP9 RGN RXRA RXRB RXRG SEPP1 SLC16A2 SRC SUV39H1 TBL1X TDG TRIM24 TRIP11 YWHAH YWHAQ ZBTB3	75 interactors: ABL1 AKT1 ATF1 ATF6 ATF7IP ATM ATR C14orf1 CAMK2A CCDC6 CEBPB CHD3 CHD8 CREBBP CREM CRTC1 DYRK1A EDF1 EP300 FHL5 GLI2 GSK3A GSK3B GTF2A1 GTF2F2 HIPK3 HNF1B HPS6 KAT5 KCNIP3 KIAA2026 MAPK14 MAPKAPK2 MTF2 MYC NR3C1 PDX1 PIAS1 POGZ POU2F1 PPP1CA PRKACA PRKG1 RAB1A RBBP4 RECQL5 RFX3 RGS13 RNF111 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 SGK1 SMARCA4 SMARCA5 SOX9 SRA1 SREBF2 SRF SUZ12 THRA TOX4 TRIM22 TSSK4 UBE2I VIM YY1 ZHX1 ZMYM2 ZNF35 ZNF436 ZNF451 ZNF92
Entrez ID		7067	1385
HPRD ID		07185	00442
Ensembl ID		ENSG00000126351	ENSG00000118260
Uniprot IDs		P10827 Q6FH41	P16220 Q53X93 Q5U0J5
PDB IDs		1NAV 2H77 2H79 3HZF 3ILZ 3JZB	2LXT
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Rhythmic Process Organ Development Multicellular Organismal Development Regulation Of Cellular Process Anatomical Structure Development Developmental Process Cellular Response To Organic Substance Signal Transduction Chromosome Organization Signaling System Development	Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Gene Expression Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Peptidyl-serine Phosphorylation Negative Regulation Of Gene Expression Regulation Of Cellular Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Organic Substance Cellular Response To Stress Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Chromatin Modification Chromatin Organization Response To Stress Regulation Of Signaling Peptidyl-amino Acid Modification Regulation Of Cellular Response To Heat Organelle Organization Cell Differentiation Transcription From RNA Polymerase II Promoter
Tagcloud ?		accounts averages bimodality bxd bxh chr counted encode ganglion heritable hoxb idea inbred krt1 lod mapped neuregulin nnc1 opposed qtl qtls retina retinal striking subsidiary surprisingly thyroxine trait vertebrate	aao acting allelic chemokine citrate emerged enrichment exceeded fact fdr fdraao fdrmsss gwas hubs influencing italian leukocyte msss network networks nominally ppms sclerosis severity snps tca trait traits transendothelial
Tagcloud (Difference) ?		accounts averages bimodality bxd bxh chr counted encode ganglion heritable hoxb idea inbred krt1 lod mapped neuregulin nnc1 opposed qtl qtls retina retinal striking subsidiary surprisingly thyroxine vertebrate	aao acting allelic chemokine citrate emerged enrichment exceeded fact fdr fdraao fdrmsss gwas hubs influencing italian leukocyte msss network networks nominally ppms sclerosis severity snps tca traits transendothelial
Tagcloud (Intersection) ?		trait