THRA and BTG1

Number of citations of the paper that reports this interaction (PMID 15674337)
9

Data Source:
HPRD (in vivo, in vitro)

		THRA	BTG1
Gene Name		thyroid hormone receptor, alpha	B-cell translocation gene 1, anti-proliferative
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Cytoplasm
	Molecular Function	Steroid Receptor RNA Activator RNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Thyroid Hormone Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding TBP-class Protein Binding Protein Domain Specific Binding Chromatin DNA Binding Protein Complex Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Thyroid Hormone Binding	Transcription Cofactor Activity Protein Binding Enzyme Binding Kinase Binding
	Biological Process	Cartilage Condensation Ossification Regulation Of Thyroid Hormone Mediated Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Learning Or Memory Regulation Of Heart Contraction Female Courtship Behavior Response To Cold Hormone-mediated Signaling Pathway Gene Expression Positive Regulation Of Myotube Differentiation Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Erythrocyte Differentiation Intracellular Receptor Signaling Pathway Thyroid Gland Development Regulation Of Myeloid Cell Apoptotic Process Cytoplasmic Sequestering Of Transcription Factor Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Female Receptivity Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Catabolic Process Type I Pneumocyte Differentiation Negative Regulation Of DNA-templated Transcription, Initiation	Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Proliferation Cell Migration Negative Regulation Of Cell Growth Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Fibroblast Apoptotic Process
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs		Liothyronine Levothyroxine Dextrothyroxine Liotrix 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid
Diseases
GWAS		White blood cell count ( 21738480)	Heart failure ( 20445134)
Protein-Protein Interactions		56 interactors: AKAP13 AMOTL2 ARID5A BTG1 BUB3 C1D CCND1 CDK7 CLIC1 COPS2 CREB1 CREBBP CUL1 DAP3 ESR1 FOXJ1 FUS GRIP1 GTF2B HDAC2 HDAC3 ITGB3BP L3MBTL3 MED1 MED21 MED25 MEF2A NCOA1 NCOA6 NCOR1 NCOR2 NR0B2 NR2F1 NRIP1 NSD1 OASL PML POU2F1 PRKDC PTGES3 RANBP9 RGN RXRA RXRB RXRG SEPP1 SLC16A2 SRC SUV39H1 TBL1X TDG TRIM24 TRIP11 YWHAH YWHAQ ZBTB3	12 interactors: CCNA2 CNOT7 CNOT8 HOXB9 PRMT1 RARA RNF181 SKP2 THRA THRB TUBA1A XRCC6
Entrez ID		7067	694
HPRD ID		07185	15912
Ensembl ID		ENSG00000126351
Uniprot IDs		P10827 Q6FH41	P62324 Q6IBC8
PDB IDs		1NAV 2H77 2H79 3HZF 3ILZ 3JZB
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Rhythmic Process Organ Development Multicellular Organismal Development Regulation Of Cellular Process Anatomical Structure Development Developmental Process Cellular Response To Organic Substance Signal Transduction Chromosome Organization Signaling System Development	Female Courtship Behavior Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Female Receptivity Positive Regulation Of Cellular Metabolic Process Female Mating Behavior Type I Pneumocyte Differentiation Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated G2/M Transition Of Mitotic Cell Cycle Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Proliferation Regulation Of RNA Metabolic Process Transcription, DNA-templated Hormone-mediated Signaling Pathway Positive Regulation Of MRNA Catabolic Process RNA Biosynthetic Process Positive Regulation Of Metabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Response To Steroid Hormone Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Transcription Initiation From RNA Polymerase II Promoter Mating Behavior Regulation Of Gene Expression Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Steroid Hormone Stimulus RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Response To Stimulus Intracellular Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Gene Silencing By MiRNA DNA-templated Transcription, Initiation Posttranscriptional Gene Silencing Mating Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Lung Epithelial Cell Differentiation Regulation Of Translation Respiratory System Development RNA Metabolic Process Lung Cell Differentiation Lung Epithelium Development Gene Silencing By RNA
Tagcloud ?		accounts averages bimodality bxd bxh chr counted encode ganglion heritable hoxb idea inbred krt1 lod mapped neuregulin nnc1 opposed qtl qtls retina retinal striking subsidiary surprisingly thyroxine trait vertebrate	accompanied achn adjacent bcell biopsies biopsy blotting empty endoscopic fraction g0 immediately indicator kidney lebtg1 leempty lentivirus lymphoma metalloproteinase proportion regulator respect serve stably transfected utilizing vectortransfected vs
Tagcloud (Difference) ?		accounts averages bimodality bxd bxh chr counted encode ganglion heritable hoxb idea inbred krt1 lod mapped neuregulin nnc1 opposed qtl qtls retina retinal striking subsidiary surprisingly thyroxine trait vertebrate	accompanied achn adjacent bcell biopsies biopsy blotting empty endoscopic fraction g0 immediately indicator kidney lebtg1 leempty lentivirus lymphoma metalloproteinase proportion regulator respect serve stably transfected utilizing vectortransfected vs
Tagcloud (Intersection) ?