THRA and RGN

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		THRA	RGN
Gene Name		thyroid hormone receptor, alpha	regucalcin
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Steroid Receptor RNA Activator RNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Thyroid Hormone Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding TBP-class Protein Binding Protein Domain Specific Binding Chromatin DNA Binding Protein Complex Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Thyroid Hormone Binding	Gluconolactonase Activity Calcium Ion Binding Zinc Ion Binding Enzyme Regulator Activity
	Biological Process	Cartilage Condensation Ossification Regulation Of Thyroid Hormone Mediated Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Learning Or Memory Regulation Of Heart Contraction Female Courtship Behavior Response To Cold Hormone-mediated Signaling Pathway Gene Expression Positive Regulation Of Myotube Differentiation Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Erythrocyte Differentiation Intracellular Receptor Signaling Pathway Thyroid Gland Development Regulation Of Myeloid Cell Apoptotic Process Cytoplasmic Sequestering Of Transcription Factor Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Female Receptivity Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Catabolic Process Type I Pneumocyte Differentiation Negative Regulation Of DNA-templated Transcription, Initiation	Cellular Calcium Ion Homeostasis L-ascorbic Acid Biosynthetic Process Positive Regulation Of ATPase Activity Regulation Of Calcium-mediated Signaling
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs		Liothyronine Levothyroxine Dextrothyroxine Liotrix 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid
Diseases
GWAS		White blood cell count ( 21738480)
Protein-Protein Interactions		56 interactors: AKAP13 AMOTL2 ARID5A BTG1 BUB3 C1D CCND1 CDK7 CLIC1 COPS2 CREB1 CREBBP CUL1 DAP3 ESR1 FOXJ1 FUS GRIP1 GTF2B HDAC2 HDAC3 ITGB3BP L3MBTL3 MED1 MED21 MED25 MEF2A NCOA1 NCOA6 NCOR1 NCOR2 NR0B2 NR2F1 NRIP1 NSD1 OASL PML POU2F1 PRKDC PTGES3 RANBP9 RGN RXRA RXRB RXRG SEPP1 SLC16A2 SRC SUV39H1 TBL1X TDG TRIM24 TRIP11 YWHAH YWHAQ ZBTB3	2 interactors: NR1D2 THRA
Entrez ID		7067	9104
HPRD ID		07185	02196
Ensembl ID		ENSG00000126351	ENSG00000130988
Uniprot IDs		P10827 Q6FH41	Q15493
PDB IDs		1NAV 2H77 2H79 3HZF 3ILZ 3JZB	3G4E 3G4H 4GNB 4GNC
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Rhythmic Process Organ Development Multicellular Organismal Development Regulation Of Cellular Process Anatomical Structure Development Developmental Process Cellular Response To Organic Substance Signal Transduction Chromosome Organization Signaling System Development	Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Regulation Of Lipid Metabolic Process Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Positive Regulation Of Female Receptivity Cellular Response To Organic Cyclic Compound Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Lipid Response To Steroid Hormone Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Cellular Response To Hormone Stimulus Female Courtship Behavior Regulation Of Thyroid Hormone Mediated Signaling Pathway Regulation Of Energy Homeostasis Regulation Of Female Receptivity Female Mating Behavior Response To Lipid Type I Pneumocyte Differentiation Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Regulation Of Skeletal Muscle Cell Differentiation Cytoplasmic Sequestering Of Transcription Factor Response To Hormone Cytoplasmic Sequestering Of Protein Cartilage Condensation Regulation Of DNA-templated Transcription, Initiation Thyroid Gland Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Myotube Differentiation Mating Behavior Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Homeostatic Process Negative Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Mating Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Response To Cold Regulation Of Lipid Catabolic Process Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?		accounts averages bimodality bxd bxh chr counted encode ganglion heritable hoxb idea inbred krt1 lod mapped neuregulin nnc1 opposed qtl qtls retina retinal striking subsidiary surprisingly thyroxine trait vertebrate	actinomycin antiapoptotic counterparts diminished enzymatic ex fertility germ herein inducers modulating mug noxious oncological overexpressing preservation proapoptotic protects regucalcin seminiferous set situations suppresses testicular testis tg thap thapsigargin tubules
Tagcloud (Difference) ?		accounts averages bimodality bxd bxh chr counted encode ganglion heritable hoxb idea inbred krt1 lod mapped neuregulin nnc1 opposed qtl qtls retina retinal striking subsidiary surprisingly thyroxine trait vertebrate	actinomycin antiapoptotic counterparts diminished enzymatic ex fertility germ herein inducers modulating mug noxious oncological overexpressing preservation proapoptotic protects regucalcin seminiferous set situations suppresses testicular testis tg thap thapsigargin tubules
Tagcloud (Intersection) ?