THRA and TRIM24

Number of citations of the paper that reports this interaction (PMID 9115274)
11

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		THRA	TRIM24
Gene Name		thyroid hormone receptor, alpha	tripartite motif containing 24
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Nuclear Euchromatin Perichromatin Fibrils Cytosol
	Molecular Function	Steroid Receptor RNA Activator RNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Thyroid Hormone Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding TBP-class Protein Binding Protein Domain Specific Binding Chromatin DNA Binding Protein Complex Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Thyroid Hormone Binding	P53 Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Ubiquitin-protein Transferase Activity Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Ligand-dependent Nuclear Receptor Binding Estrogen Response Element Binding Methylated Histone Binding Sequence-specific DNA Binding Lysine-acetylated Histone Binding
	Biological Process	Cartilage Condensation Ossification Regulation Of Thyroid Hormone Mediated Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Learning Or Memory Regulation Of Heart Contraction Female Courtship Behavior Response To Cold Hormone-mediated Signaling Pathway Gene Expression Positive Regulation Of Myotube Differentiation Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Erythrocyte Differentiation Intracellular Receptor Signaling Pathway Thyroid Gland Development Regulation Of Myeloid Cell Apoptotic Process Cytoplasmic Sequestering Of Transcription Factor Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Female Receptivity Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Catabolic Process Type I Pneumocyte Differentiation Negative Regulation Of DNA-templated Transcription, Initiation	Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Protein Ubiquitination Protein Catabolic Process Regulation Of Protein Stability Regulation Of Apoptotic Process Response To Peptide Hormone Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Calcium Ion Homeostasis Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Estrogen Stimulus Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	Signaling by FGFR in disease Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants
Drugs		Liothyronine Levothyroxine Dextrothyroxine Liotrix 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid
Diseases
GWAS		White blood cell count ( 21738480)	Quantitative traits ( 19197348)
Protein-Protein Interactions		56 interactors: AKAP13 AMOTL2 ARID5A BTG1 BUB3 C1D CCND1 CDK7 CLIC1 COPS2 CREB1 CREBBP CUL1 DAP3 ESR1 FOXJ1 FUS GRIP1 GTF2B HDAC2 HDAC3 ITGB3BP L3MBTL3 MED1 MED21 MED25 MEF2A NCOA1 NCOA6 NCOR1 NCOR2 NR0B2 NR2F1 NRIP1 NSD1 OASL PML POU2F1 PRKDC PTGES3 RANBP9 RGN RXRA RXRB RXRG SEPP1 SLC16A2 SRC SUV39H1 TBL1X TDG TRIM24 TRIP11 YWHAH YWHAQ ZBTB3	47 interactors: AR ATF4 BRCA1 BRD7 CBX1 CBX3 CBX5 ESR1 ESR2 FOSL1 GTF2E1 HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HNF4A HSPA1A NFE2L2 NR2F2 NR3C1 NR3C2 PGR PML PPARG RARA RNF141 RNF181 RXRA STAT6 SUMO1 TAF11 TAF1B TAF1C TAF7 THRA TRIM28 TRIM33 TRIM8 UBE2U VDR ZNF10
Entrez ID		7067	8805
HPRD ID		07185	04556
Ensembl ID		ENSG00000126351	ENSG00000122779
Uniprot IDs		P10827 Q6FH41	O15164
PDB IDs		1NAV 2H77 2H79 3HZF 3ILZ 3JZB	2YYN 3O33 3O34 3O35 3O36 3O37
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Rhythmic Process Organ Development Multicellular Organismal Development Regulation Of Cellular Process Anatomical Structure Development Developmental Process Cellular Response To Organic Substance Signal Transduction Chromosome Organization Signaling System Development	Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Chromatin Silencing At RDNA Regulation Of Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Gene Expression Transcription Initiation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Replication-dependent Nucleosome Assembly Chromatin Silencing Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA Methylation On Cytosine Steroid Hormone Mediated Signaling Pathway Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Gene Silencing Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Transcription From RNA Polymerase II Promoter Hormone-mediated Signaling Pathway DNA Methylation Gene Silencing Regulation Of Gene Expression, Epigenetic Cellular Response To Steroid Hormone Stimulus Transcription, DNA-templated DNA Modification RNA Biosynthetic Process Response To Steroid Hormone Cellular Response To Organic Cyclic Compound Cellular Metabolic Process RNA Metabolic Process Protein-DNA Complex Assembly Nucleosome Assembly Chromatin Assembly Cellular Macromolecule Biosynthetic Process Nucleosome Organization Cellular Response To Lipid Macromolecule Biosynthetic Process Chromatin Assembly Or Disassembly
Tagcloud ?		accounts averages bimodality bxd bxh chr counted encode ganglion heritable hoxb idea inbred krt1 lod mapped neuregulin nnc1 opposed qtl qtls retina retinal striking subsidiary surprisingly thyroxine trait vertebrate	advance aerobic alongside bromodomain doi ectopic glycolysis glycolytic greatly hmec hmecs homeodomain ihmecs immortalized isogenic july mammoplasty nude onc online publication reader reprogramming signature subcutaneous tricarboxylic tripartite tumorigenesis viable
Tagcloud (Difference) ?		accounts averages bimodality bxd bxh chr counted encode ganglion heritable hoxb idea inbred krt1 lod mapped neuregulin nnc1 opposed qtl qtls retina retinal striking subsidiary surprisingly thyroxine trait vertebrate	advance aerobic alongside bromodomain doi ectopic glycolysis glycolytic greatly hmec hmecs homeodomain ihmecs immortalized isogenic july mammoplasty nude onc online publication reader reprogramming signature subcutaneous tricarboxylic tripartite tumorigenesis viable
Tagcloud (Intersection) ?