THRA and SLC16A2

Number of citations of the paper that reports this interaction (PMID 12871948)
76

Data Source:
HPRD (in vivo, in vitro)

		THRA	SLC16A2
Gene Name		thyroid hormone receptor, alpha	solute carrier family 16, member 2 (thyroid hormone transporter)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Steroid Receptor RNA Activator RNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Thyroid Hormone Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding TBP-class Protein Binding Protein Domain Specific Binding Chromatin DNA Binding Protein Complex Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Thyroid Hormone Binding	Transporter Activity Monocarboxylic Acid Transmembrane Transporter Activity Symporter Activity Thyroid Hormone Transmembrane Transporter Activity
	Biological Process	Cartilage Condensation Ossification Regulation Of Thyroid Hormone Mediated Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Learning Or Memory Regulation Of Heart Contraction Female Courtship Behavior Response To Cold Hormone-mediated Signaling Pathway Gene Expression Positive Regulation Of Myotube Differentiation Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Erythrocyte Differentiation Intracellular Receptor Signaling Pathway Thyroid Gland Development Regulation Of Myeloid Cell Apoptotic Process Cytoplasmic Sequestering Of Transcription Factor Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Female Receptivity Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Catabolic Process Type I Pneumocyte Differentiation Negative Regulation Of DNA-templated Transcription, Initiation	Transport Monocarboxylic Acid Transport Ion Transmembrane Transport Thyroid Hormone Transport
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs		Liothyronine Levothyroxine Dextrothyroxine Liotrix 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid	Pyruvic acid
Diseases
GWAS		White blood cell count ( 21738480)
Protein-Protein Interactions		56 interactors: AKAP13 AMOTL2 ARID5A BTG1 BUB3 C1D CCND1 CDK7 CLIC1 COPS2 CREB1 CREBBP CUL1 DAP3 ESR1 FOXJ1 FUS GRIP1 GTF2B HDAC2 HDAC3 ITGB3BP L3MBTL3 MED1 MED21 MED25 MEF2A NCOA1 NCOA6 NCOR1 NCOR2 NR0B2 NR2F1 NRIP1 NSD1 OASL PML POU2F1 PRKDC PTGES3 RANBP9 RGN RXRA RXRB RXRG SEPP1 SLC16A2 SRC SUV39H1 TBL1X TDG TRIM24 TRIP11 YWHAH YWHAQ ZBTB3	2 interactors: SERPINA7 THRA
Entrez ID		7067	6567
HPRD ID		07185	02106
Ensembl ID		ENSG00000126351	ENSG00000147100
Uniprot IDs		P10827 Q6FH41	P36021
PDB IDs		1NAV 2H77 2H79 3HZF 3ILZ 3JZB
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Rhythmic Process Organ Development Multicellular Organismal Development Regulation Of Cellular Process Anatomical Structure Development Developmental Process Cellular Response To Organic Substance Signal Transduction Chromosome Organization Signaling System Development	Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Positive Regulation Of Female Receptivity Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Response To Steroid Hormone Thyroid Hormone Transport Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Female Courtship Behavior Regulation Of Thyroid Hormone Mediated Signaling Pathway Regulation Of Female Receptivity Female Mating Behavior Response To Lipid Type I Pneumocyte Differentiation Response To Organic Cyclic Compound Cytoplasmic Sequestering Of Transcription Factor Response To Prostaglandin E Response To Hormone Cytoplasmic Sequestering Of Protein Cartilage Condensation Regulation Of DNA-templated Transcription, Initiation Thyroid Gland Development Response To Vitamin A Positive Regulation Of Myotube Differentiation Mating Behavior Response To Corticosterone Regulation Of Myeloid Cell Apoptotic Process Response To Mineralocorticoid Negative Regulation Of Transcription Factor Import Into Nucleus Mating Response To Cold Regulation Of Lipid Catabolic Process Regulation Of Myotube Differentiation Lung Epithelial Cell Differentiation Positive Regulation Of Striated Muscle Cell Differentiation Lung Cell Differentiation Lung Epithelium Development Negative Regulation Of Protein Import Into Nucleus Response To Fatty Acid Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Muscle Cell Differentiation Negative Regulation Of Intracellular Protein Transport Regulation Of Transcription Factor Import Into Nucleus Hormone Transport Negative Regulation Of Cellular Metabolic Process Regulation Of Striated Muscle Cell Differentiation Erythrocyte Differentiation Steroid Hormone Mediated Signaling Pathway Response To Vitamin Erythrocyte Homeostasis Negative Regulation Of Intracellular Transport
Tagcloud ?		accounts averages bimodality bxd bxh chr counted encode ganglion heritable hoxb idea inbred krt1 lod mapped neuregulin nnc1 opposed qtl qtls retina retinal striking subsidiary surprisingly thyroxine trait vertebrate	cga deiodinase dio2 hypothalamic hypothalamus intra intraperitoneal ko littermates mct mct8 nbr neuromedin paracrine pituitary releasing slight t3 t4 thrb thyroid thyroidal thyrotropin thyroxine trh trhr triiodothyronine tsh tshb
Tagcloud (Difference) ?		accounts averages bimodality bxd bxh chr counted encode ganglion heritable hoxb idea inbred krt1 lod mapped neuregulin nnc1 opposed qtl qtls retina retinal striking subsidiary surprisingly trait vertebrate	cga deiodinase dio2 hypothalamic hypothalamus intra intraperitoneal ko littermates mct mct8 nbr neuromedin paracrine pituitary releasing slight t3 t4 thrb thyroid thyroidal thyrotropin trh trhr triiodothyronine tsh tshb
Tagcloud (Intersection) ?		thyroxine