NEFM and NEFH

Number of citations of the paper that reports this interaction (PMID 2557834)
1

Data Source:
HPRD (in vitro)

		NEFM	NEFH
Gene Name		neurofilament, medium polypeptide	neurofilament, heavy polypeptide
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Neurofilament Axon Neuromuscular Junction Neurofibrillary Tangle	Cytoplasm Mitochondrion Neurofilament Axon Neurofibrillary Tangle
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Microtubule Binding Kinesin Binding Protein Kinase Binding Protein Binding, Bridging Dynein Binding
	Biological Process	Microtubule Cytoskeleton Organization Axon Cargo Transport Regulation Of Axon Diameter Neurofilament Bundle Assembly	Microtubule Cytoskeleton Organization Axonogenesis Cell Projection Assembly Neurofilament Bundle Assembly Peripheral Nervous System Neuron Axonogenesis Axon Development Regulation Of Organelle Transport Along Microtubule
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: APOE DISC1 FOS MINK1 NEFH RB1 SMAD2 STXBP1 TNIK	5 interactors: MAPK1 NEFL NEFM PKN1 STXBP1
Entrez ID		4741	4744
HPRD ID		01205	01204
Ensembl ID		ENSG00000104722	ENSG00000100285
Uniprot IDs		E7EMV2 E7ESP9 P07197 Q9UK51	P12036
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Differentiation Nervous System Development System Development Generation Of Neurons Neurogenesis Multicellular Organismal Development Intracellular Signal Transduction Anatomical Structure Development Cytoskeleton Organization Cell Projection Organization Developmental Process Positive Regulation Of Cellular Metabolic Process Neuron Projection Development Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Neuron Development Cell Development Regulation Of Signaling Protein Localization Regulation Of Cellular Component Organization Organelle Organization Positive Regulation Of Cellular Protein Catabolic Process Neuron Differentiation Response To Cholesterol Positive Regulation Of Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Protein Catabolic Process Cellular Protein Localization Cellular Localization MAPK Cascade Anatomical Structure Morphogenesis Signaling Cell Communication Cell Morphogenesis Involved In Differentiation Signal Transduction By Phosphorylation Positive Regulation Of Proteolysis Regulation Of Signal Transduction Positive Regulation Of Myeloid Leukocyte Differentiation SMAD Protein Signal Transduction Regulation Of Cell Development Skeletal Muscle Cell Differentiation Cell-cell Signaling Actin Cytoskeleton Reorganization Protein Localization To Membrane Regulation Of Neuron Projection Development Regulation Of Protein Catabolic Process Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process	Neurofilament Bundle Assembly Intermediate Filament Bundle Assembly Regulation Of Axon Diameter Regulation Of Cell Projection Size Neurofilament Cytoskeleton Organization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Peptidyl-threonine Phosphorylation Axon Cargo Transport Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis Axon Development Synaptic Transmission Neuron Projection Morphogenesis Regulation Of Cellular Component Organization Stress-activated MAPK Cascade Establishment Of Localization In Cell Response To Wounding Stress-activated Protein Kinase Signaling Cascade Microtubule-based Transport Regulation Of Protein Stability Cytoskeleton-dependent Intracellular Transport Activation Of MAPK Activity Neuron Projection Development MAPK Import Into Nucleus Nervous System Development Cell Projection Morphogenesis Regulation Of Axonogenesis Cell Part Morphogenesis Cellular Localization Cell-cell Signaling Negative Regulation Of Neuron Apoptotic Process Response To Toxic Substance Regulation Of Stress-activated MAPK Cascade Neuron Development Platelet Activation Negative Regulation Of Neuron Death Regulation Of Golgi Inheritance Positive Regulation Of MAP Kinase Activity Cell Morphogenesis MAPK Cascade Caveolin-mediated Endocytosis Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Axon Target Recognition Cytosine Metabolic Process Regulation Of Neuron Apoptotic Process Neuron Differentiation Cell Projection Organization
Tagcloud ?			carriers certainty cryb2 d22s268 d22s280 deafness dominantly gadolinium gardner inherited linkage manifestations manifests mri neuro neurofibromatosis neurologic nf2 ophthalmologic otologic pedigree predisposes presymptomatic schwannomas slowly spine thoroughly typically vestibular
Tagcloud (Difference) ?			carriers certainty cryb2 d22s268 d22s280 deafness dominantly gadolinium gardner inherited linkage manifestations manifests mri neuro neurofibromatosis neurologic nf2 ophthalmologic otologic pedigree predisposes presymptomatic schwannomas slowly spine thoroughly typically vestibular
Tagcloud (Intersection) ?