DPYSL3

Name	dihydropyrimidinase like 3
Structure
Novel Interactors	1 novel interactors: HYOU1
Interactors	7 interactors: ACD DISC1 DPYSL5 OTUD6A POT1 TERF1 TNIK
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Lamellipodium Growth Cone Filamentous Actin Cell Projection Cell Body Synapse Exocytic Vesicle
	Molecular Function	Dihydropyrimidinase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides SH3 Domain Binding Filamin Binding Chondroitin Sulfate Binding Identical Protein Binding Phosphoprotein Binding
	Biological Process	Pyrimidine Nucleobase Catabolic Process Nervous System Development Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Neuron Development Response To Axon Injury Actin Filament Bundle Assembly Positive Regulation Of Filopodium Assembly Actin Crosslink Formation Cellular Response To Cytokine Stimulus
Pathways	CRMPs in Sema3A signaling
GWAS	Brain morphology (MOSTest) ( 32665545 ) Excessive daytime sleepiness ( 27992416 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Metabolite levels ( 23823483 ) Subcortical volume (MOSTest) ( 32665545 )
Entrez ID	1809
HPRD ID	03104
Ensembl ID	ENSG00000113657
Uniprot IDs	A0A140VK07 Q14195 Q6DEN2 Q8IXW6
PDB IDs	4BKN 4CNS 4CNT 4CNU
GO Terms Enriched among Interactors ?	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome Positive Regulation Of Telomere Maintenance Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Telomeric D-loop Disassembly DNA Biosynthetic Process G-rich Strand Telomeric DNA Binding Telomere Maintenance Telomeric Loop Disassembly Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Cellular Component Organization Chromosome, Telomeric Region Regulation Of Chromosome Organization Negative Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Positive Regulation Of DNA Metabolic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Chromosome Organization Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Regulation Of Dendrite Morphogenesis Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding System Development Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Neuron Projection Development