DYNC1H1 and TNIK

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		DYNC1H1	TNIK
Gene Name		dynein, cytoplasmic 1, heavy chain 1	TRAF2 and NCK interacting kinase
Image
Gene Ontology Annotations	Cellular Component	Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Membrane Filopodium Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Apical Plasma Membrane Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding ATPase Activity Poly(A) RNA Binding Dynein Light Intermediate Chain Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Transport Organelle Organization Microtubule-based Movement Mitotic Spindle Organization Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cytoplasmic MRNA Processing Body Assembly Stress Granule Assembly	Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Cytoskeleton Organization Activation Of JNKK Activity Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Reorganization Intracellular Signal Transduction Protein Autophosphorylation Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane
Pathways		Organelle biogenesis and maintenance Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System	Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS			Brain imaging in schizophrenia (interaction) ( 19023125) Coronary heart disease ( 21347282)
Protein-Protein Interactions		14 interactors: BRCA1 DISC1 DYNLL1 EGFR FAM46A KATNA1 KATNB1 NDEL1 PRKCD SMAD2 SNCA TNIK YWHAG YWHAQ	38 interactors: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DISC1 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SLC9A1 SMARCE1 SNX6 SOS1 SPTBN1 SRGAP3 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1
Entrez ID		1778	23043
HPRD ID		02524	18206
Ensembl ID		ENSG00000197102	ENSG00000154310
Uniprot IDs		Q14204	Q9UKE5
PDB IDs		2BOR 2BOT	2X7F
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Regulation Of Signal Transduction Regulation Of Signaling Intrinsic Apoptotic Signaling Pathway Developmental Process Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Cell Projection Organization Positive Regulation Of Intracellular Transport Regulation Of Cell Development Cell Cycle Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Organelle Organization Regulation Of Neuron Differentiation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Positive Regulation Of Cell Death Cell Cycle Process Nervous System Development Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Signaling Pathway Mitotic Cell Cycle Process Cellular Localization Regulation Of Neurogenesis Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Neuron Projection Development Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Transport Mitotic Cell Cycle Positive Regulation Of Organelle Organization Microtubule-based Process Protein Localization Regulation Of Intracellular Transport Multicellular Organismal Development Positive Regulation Of Apoptotic Signaling Pathway Membrane Organization Positive Regulation Of Mitochondrion Organization Anatomical Structure Development Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Process Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Response To DNA Damage Stimulus Apoptotic Process Generation Of Neurons Regulation Of Cell Differentiation Microtubule Severing Programmed Cell Death Organelle Organization System Development Positive Regulation Of Apoptotic Process	Neurogenesis Nervous System Development Cellular Component Assembly Movement Of Cell Or Subcellular Component Cell Differentiation Organelle Organization Generation Of Neurons Cytoskeleton Organization Regulation Of Neuron Projection Development Regulation Of Cellular Component Organization Locomotion Regulation Of Cell Projection Organization System Development Regulation Of Neuron Differentiation Anatomical Structure Development Endomembrane System Organization Regulation Of Cellular Component Size Signaling Multicellular Organismal Development Signal Transduction Cell Projection Organization Cell Communication Regulation Of Neurogenesis Cellular Localization Plasma Membrane Organization Regulation Of Signal Transduction Axonogenesis Developmental Process Positive Regulation Of Signal Transduction Axon Guidance Axon Development Cellular Response To Stimulus Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Development Cell Morphogenesis Protein Localization To Plasma Membrane Cell Projection Morphogenesis Membrane Organization Regulation Of Cell Development Regulation Of Signaling Cell Part Morphogenesis Neuron Projection Morphogenesis Neuron Differentiation Golgi To Plasma Membrane Protein Transport Anatomical Structure Morphogenesis Establishment Of Protein Localization To Plasma Membrane Establishment Or Maintenance Of Cell Polarity Cell Development Protein Localization To Organelle Cell Morphogenesis Involved In Differentiation
Tagcloud ?		200x customized dcx depths exome flna funded heterotopia kif5c kinesin malformations megalencephaly mosaicism neurodevelopmental neuropsychiatric nodular pachygyria panels periventricular persons polymicrogyria read sanger somatic subcloned subcloning subcortical tubb2b unequal	a549 attenuation carboxamide competition continuing crosstalk docking efforts emerging emt fak focal hinge ky methylbenzamido motility nck orchestrated paxillin pharmacologic phenylamino smad tgf thiazole traf2 transforming triggers validate wnt
Tagcloud (Difference) ?		200x customized dcx depths exome flna funded heterotopia kif5c kinesin malformations megalencephaly mosaicism neurodevelopmental neuropsychiatric nodular pachygyria panels periventricular persons polymicrogyria read sanger somatic subcloned subcloning subcortical tubb2b unequal	a549 attenuation carboxamide competition continuing crosstalk docking efforts emerging emt fak focal hinge ky methylbenzamido motility nck orchestrated paxillin pharmacologic phenylamino smad tgf thiazole traf2 transforming triggers validate wnt
Tagcloud (Intersection) ?