DIP2C and PCBD1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		DIP2C	PCBD1
Description		disco interacting protein 2 homolog C	pterin-4 alpha-carbinolamine dehydratase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Molecular_function	Transcription Coactivator Activity Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Lyase Activity Identical Protein Binding
	Biological Process	Biological_process	Tetrahydrobiopterin Biosynthetic Process Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Positive Regulation Of DNA-templated Transcription
Pathways			Phenylalanine metabolism
Drugs			L-erythro-7,8-dihydrobiopterin
Diseases			Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) Chronotype ( 30696823) Frontal pole volume ( 31530798) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Lateral ventricle temporal horn volume ( 31530798) Malaria ( 31844061) Psychosis in Alzheimer's disease ( 22005930) Uric acid levels ( 23703922)	Blood protein levels ( 30072576) Chronotype ( 30696823) Immature fraction of reticulocytes ( 27863252) Microalbuminuria ( 26631737) Obesity-related traits ( 23251661)
Interacting Genes		1 interacting genes: PCBD1	53 interacting genes: ACIN1 APP BRD7 CACNA1C CALCOCO1 CDK5RAP2 CEBPZ DENND4A DIP2C DVL2 DYRK1B EHMT1 FXR2 GORASP2 GTF3C3 HES4 HNF1A HNF4A KANK2 KLF13 LNX1 MIS18BP1 NFKB1 NIF3L1 NTAQ1 NUDT18 PAH PAPOLG PCBD2 PICK1 POLR3A PSMA1 RBL2 RPS24 SAP30 SCMH1 SDCBP SMARCD1 SOWAHC SUPT5H TFF3 TIMELESS TRIM5 WWP1 ZBTB25 ZNF195 ZNF202 ZNF23 ZNF263 ZNF451 ZNF567 ZNF688 ZNF714
Entrez ID		22982	5092
HPRD ID		17200	00523
Ensembl ID		ENSG00000151240	ENSG00000166228
Uniprot IDs		A0A0U1RQW6 Q86XV3 Q9Y2E4	P61457
PDB IDs
Enriched GO Terms of Interacting Partners?		4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Positive Regulation Of 3'-UTR-mediated MRNA Stabilization Tetrahydrobiopterin Biosynthetic Process Tetrahydrobiopterin Metabolic Process Pteridine-containing Compound Biosynthetic Process Tyrosine Metabolic Process Diol Metabolic Process Pteridine-containing Compound Metabolic Process Aromatic Amino Acid Metabolic Process Amino Acid Biosynthetic Process Cytoplasmic Stress Granule	Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Zinc Ion Binding Chromatin Binding Positive Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Frizzled Binding Epigenetic Regulation Of Gene Expression Metal Ion Binding Positive Regulation Of Biosynthetic Process Transcription Coactivator Activity Nucleoplasm Positive Regulation Of Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific TRNA Transcription By RNA Polymerase III TRNA Transcription Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Macromolecule Metabolic Process Transcription Coregulator Activity Regulation Of Mitotic Cell Cycle DNA-binding Transcription Factor Activity RSC-type Complex Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition
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