DYNC2H1 and DYNC2LI1

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		DYNC2H1	DYNC2LI1
Description		dynein cytoplasmic 2 heavy chain 1	dynein cytoplasmic 2 light intermediate chain 1
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytoskeleton Cytoplasmic Dynein Complex Microtubule Plasma Membrane Cilium Axoneme Membrane Dynein Complex Motile Cilium Cell Projection Apical Part Of Cell Extracellular Exosome Ciliary Tip 9+2 Motile Cilium	Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Cilium Axoneme Nuclear Speck Dynein Complex Motile Cilium Ciliary Transition Zone Ciliary Basal Body Cell Projection Apical Part Of Cell Ciliary Tip
	Molecular Function	Nucleotide Binding Cytoskeletal Motor Activity Protein Binding ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Protein Binding Dynein Heavy Chain Binding
	Biological Process	Kidney Development Microtubule-based Movement Golgi Organization Determination Of Left/right Symmetry Heart Development Dorsal/ventral Pattern Formation Protein Processing Spinal Cord Motor Neuron Differentiation Central Nervous System Neuron Differentiation Cell Projection Organization Neuron Differentiation Embryonic Limb Morphogenesis Forebrain Development Intraciliary Retrograde Transport Positive Regulation Of Smoothened Signaling Pathway Cilium Assembly Cilium Movement Involved In Cell Motility Coronary Vasculature Development Protein Localization To Cilium Non-motile Cilium Assembly	Determination Of Left/right Symmetry Cell Projection Organization Intraciliary Retrograde Transport Intraciliary Transport Involved In Cilium Assembly Cilium Assembly Regulation Of Cilium Assembly
Pathways		Hedgehog 'off' state Intraflagellar transport	Intraflagellar transport
Drugs
Diseases		Asphyxiating thoracic dystrophy; Jeune syndrome Short rib-polydactyly syndrome
GWAS		Adult body size ( 32376654) Coronary artery disease ( 32469254 33020668) Diisocyanate-induced asthma ( 25918132) Response to lurasidone in schizophrenia ( 29730043) Small-cell lung cancer (survival) ( 21118971) Spine bone mineral density and alcohol drinking ( 28012008) Toenail selenium levels ( 25343990) Tuberculosis ( 24057671)	Coronary artery disease ( 29212778) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hematocrit ( 32888494) Hemoglobin ( 32888494) Red blood cell count ( 32888494) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		4 interacting genes: DYNC2LI1 MTNR1B PAXIP1 RNF10	3 interacting genes: CLIP4 DCDC2 DYNC2H1
Entrez ID		79659	51626
HPRD ID		10344	13116
Ensembl ID		ENSG00000187240	ENSG00000138036
Uniprot IDs		Q8NCM8	Q8TCX1
PDB IDs		4RH7 8RGG 8RGH	6RLB 6SC2 8RGH
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Smoothened Signaling Pathway Kinase Binding Regulation Of Smoothened Signaling Pathway Axoneme
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