WDR48

Description		WD repeat domain 48
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Lysosome Endosome Late Endosome Cytosol
	Molecular Function	DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding Deubiquitinase Activator Activity Ubiquitin Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Spermatogenesis Single Fertilization Male Gonad Development Multicellular Organism Growth Skin Development Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Embryonic Organ Development Skeletal System Morphogenesis Homeostasis Of Number Of Cells Positive Regulation Of Epithelial Cell Proliferation Regulation Of Macromolecule Metabolic Process Seminiferous Tubule Development Regulation Of Primary Metabolic Process Regulation Of Protein Monoubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Recognition of DNA damage by PCNA-containing replication complex Ub-specific processing proteases Fanconi Anemia Pathway Signaling by cytosolic PDGFRA and PDGFRB fusion proteins
Drugs
Diseases
GWAS		Metabolic syndrome ( 31589552) Social communication problems ( 24564958)
Novel Interacting Genes		1 novel interacting genes: TOPAZ1
Interacting Genes		7 interacting genes: NMRAL1 PAXIP1 PCNA PHLPP1 RAD51 UBC USP1
Entrez ID		57599
HPRD ID		11146
Ensembl ID		ENSG00000114742
Uniprot IDs		A0A024R2L1 Q8TAF3
PDB IDs		5CVL 5CVN 5CVO 5K1A 5K1B 5K1C 5L8E 5L8W 6JLQ 7AY0 7AY1 7AY2 8A9J 8A9K 9EBS 9HNW
Enriched GO Terms of Interacting Partners?		Regulation Of DNA Metabolic Process Response To Radiation DNA Repair DNA Polymerase Binding Replication Fork Processing DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of DNA Biosynthetic Process Regulation Of DNA Repair Male Germ Cell Nucleus DNA Damage Response PCNA Complex Replisome Response To Glucoside Positive Regulation Of Error-prone Translesion Synthesis PCNA-p21 Complex Telomere Maintenance DNA Polymerase Processivity Factor Activity Regulation Of DNA Biosynthetic Process Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Nucleic Acid Metabolic Process Mitotic Recombination-dependent Replication Fork Processing DNA Strand Exchange Activity Presynaptic Intermediate Filament Cytoskeleton Spermatocyte Division Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Chorion Development Regulation Of Cellular Response To Stress Telomere Organization Positive Regulation Of DNA Repair Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Regulation Of DNA Recombination Cellular Response To Cisplatin Response To Ionizing Radiation LncRNA Transcription Response To UV DNA Strand Invasion DNA Recombinase Assembly Cellular Response To Camptothecin Nucleobase-containing Compound Metabolic Process Nucleoplasm Cellular Response To Radiation Nuclear Ubiquitin Ligase Complex Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Response To Cisplatin Chromosome, Telomeric Region MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication
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