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WDR48 and PCNA
Number of citations of the paper that reports this interaction (PubMedID
18082604
)
0
Data Source:
BioGRID
(pull down)
WDR48
PCNA
Description
WD repeat domain 48
proliferating cell nuclear antigen
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Lysosome
Endosome
Late Endosome
Cytosol
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromosome, Telomeric Region
Chromatin
Male Germ Cell Nucleus
Nucleus
Nuclear Lamina
Nucleoplasm
Replication Fork
Centrosome
Nuclear Body
Replisome
Nuclear Replication Fork
PCNA Complex
Extracellular Exosome
PCNA-p21 Complex
Molecular Function
DNA Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Protein Binding
Deubiquitinase Activator Activity
Ubiquitin Binding
Purine-specific Mismatch Base Pair DNA N-glycosylase Activity
DNA Binding
Chromatin Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Nuclear Estrogen Receptor Binding
DNA Polymerase Processivity Factor Activity
Receptor Tyrosine Kinase Binding
Dinucleotide Insertion Or Deletion Binding
MutLalpha Complex Binding
Histone Acetyltransferase Binding
Identical Protein Binding
Protein-containing Complex Binding
DNA Polymerase Binding
Biological Process
Double-strand Break Repair Via Homologous Recombination
DNA Repair
DNA Damage Response
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Spermatogenesis
Single Fertilization
Male Gonad Development
Multicellular Organism Growth
Skin Development
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Embryonic Organ Development
Skeletal System Morphogenesis
Homeostasis Of Number Of Cells
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Macromolecule Metabolic Process
Seminiferous Tubule Development
Regulation Of Primary Metabolic Process
Regulation Of Protein Monoubiquitination
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of Transcription By RNA Polymerase II
DNA Replication
Leading Strand Elongation
Regulation Of DNA Replication
DNA Repair
Base-excision Repair, Gap-filling
Mismatch Repair
Chromatin Organization
DNA Damage Response
Response To Oxidative Stress
Heart Development
Translesion Synthesis
Epithelial Cell Differentiation
Replication Fork Processing
Positive Regulation Of Deoxyribonuclease Activity
Response To Estradiol
Response To Lipid
Cellular Response To UV
Estrous Cycle
Positive Regulation Of DNA Repair
Positive Regulation Of DNA Replication
Response To Cadmium Ion
Cellular Response To Hydrogen Peroxide
Cellular Response To Xenobiotic Stimulus
Response To Dexamethasone
Liver Regeneration
Positive Regulation Of DNA-directed DNA Polymerase Activity
Response To L-glutamate
Mitotic Telomere Maintenance Via Semi-conservative Replication
Pathways
Recognition of DNA damage by PCNA-containing replication complex
Ub-specific processing proteases
Fanconi Anemia Pathway
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Transcription of E2F targets under negative control by DREAM complex
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Removal of the Flap Intermediate from the C-strand
SUMOylation of DNA replication proteins
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
G1/S-Specific Transcription
E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Liothyronine
Acetylsalicylic acid
Diseases
GWAS
Metabolic syndrome (
31589552
)
Social communication problems (
24564958
)
Interacting Genes
7 interacting genes:
NMRAL1
PAXIP1
PCNA
PHLPP1
RAD51
UBC
USP1
142 interacting genes:
ALDOA
APEX1
APEX2
ATAD5
ATM
BAZ1B
CBX1
CCNB1
CCND1
CCND3
CCNO
CDC25C
CDC6
CDK1
CDK2
CDK5
CDK6
CDKN1A
CDKN1C
CDKN2A
CDT1
CHAF1A
CHTF18
CHTF8
CMTM5
CREBBP
DHX9
DNMT1
DNTT
DNTTIP2
DSCC1
DTL
EGFR
ENO1
EP300
ERCC5
ERCC6
ERRFI1
ESCO2
EXO1
FAN1
FANCD2
FANCL
FBH1
FEN1
GADD45A
GADD45B
GADD45G
GAPDH
GCK
GPI
HDAC1
HUS1
ING1
KCTD13
KMT5A
LDHA
LIG1
MCL1
MGMT
MLH1
MLH3
MSH2
MSH3
MSH6
MTOR
MUTYH
MYBBP1A
NEDD8
NIPBL
NMRAL1
NSD2
NTHL1
NUTF2
PARP1
PARP10
PARPBP
PCLAF
PFKM
PGAM1
PGK1
PKLR
PMS2
POLB
POLD1
POLD2
POLD3
POLD4
POLDIP2
POLE
POLH
POLI
POLK
POLL
POLM
PPP1CA
PRKDC
PTEN
PTMA
RAD18
RAD9A
RBBP8
RECQL5
RFC1
RFC2
RFC3
RFC4
RFC5
RFWD3
RPA1
S100A8
SDE2
SEC23IP
SIVA1
SLC30A8
SMARCAD1
SPG21
SUB1
SUMO1
TCOF1
TDG
TIRAP
TMEM218
TPI1
UBB
UBC
UBE2A
UBE2B
UBE2D3
UBE2I
UBE3D
UHRF1
UNG
USP4
WDR48
WRN
XPA
XRCC1
XRCC5
XRCC6
YBX1
ZBTB1
Entrez ID
57599
5111
HPRD ID
11146
01456
Ensembl ID
ENSG00000114742
ENSG00000132646
Uniprot IDs
A0A024R2L1
Q8TAF3
P12004
PDB IDs
5CVL
5CVN
5CVO
5K1A
5K1B
5K1C
5L8E
5L8W
6JLQ
7AY0
7AY1
7AY2
8A9J
8A9K
9EBS
9HNW
1AXC
1U76
1U7B
1UL1
1VYJ
1VYM
1W60
2ZVK
2ZVL
2ZVM
3JA9
3P87
3TBL
3VKX
3WGW
4D2G
4RJF
4ZTD
5E0T
5E0U
5E0V
5IY4
5MAV
5MLO
5MLW
5MOM
5YCO
5YD8
6CBI
6EHT
6FCM
6FCN
6GIS
6GWS
6HVO
6K3A
6QC0
6QCG
6S1M
6S1N
6S1O
6TNY
6TNZ
6VVO
7EFA
7KQ0
7KQ1
7M5L
7M5M
7M5N
7NV0
7NV1
7QNZ
7QO1
8B8T
8COB
8E84
8F5Q
8GCJ
8GL9
8GLA
8UI7
8UI8
8UI9
8UII
8UMT
8UMU
8UMV
8UMW
8UMY
8UN0
8YJH
8YJL
8YJQ
8YJR
8YJS
8YJU
8YJV
8YJW
8YJZ
9B8S
9B8T
9CG4
9CHM
9CL7
9CMA
9EOA
9F6D
9F6E
9F6F
9GY0
Enriched GO Terms of Interacting Partners
?
Regulation Of DNA Metabolic Process
Response To Radiation
DNA Repair
DNA Polymerase Binding
Replication Fork Processing
DNA Metabolic Process
Positive Regulation Of DNA Metabolic Process
Positive Regulation Of DNA Biosynthetic Process
Regulation Of DNA Repair
Male Germ Cell Nucleus
DNA Damage Response
PCNA Complex
Replisome
Response To Glucoside
Positive Regulation Of Error-prone Translesion Synthesis
PCNA-p21 Complex
Telomere Maintenance
DNA Polymerase Processivity Factor Activity
Regulation Of DNA Biosynthetic Process
Purine-specific Mismatch Base Pair DNA N-glycosylase Activity
Nucleic Acid Metabolic Process
Mitotic Recombination-dependent Replication Fork Processing
DNA Strand Exchange Activity
Presynaptic Intermediate Filament Cytoskeleton
Spermatocyte Division
Mitotic Telomere Maintenance Via Semi-conservative Replication
Dinucleotide Insertion Or Deletion Binding
Chorion Development
Regulation Of Cellular Response To Stress
Telomere Organization
Positive Regulation Of DNA Repair
Positive Regulation Of Deoxyribonuclease Activity
Leading Strand Elongation
Regulation Of DNA Recombination
Cellular Response To Cisplatin
Response To Ionizing Radiation
LncRNA Transcription
Response To UV
DNA Strand Invasion
DNA Recombinase Assembly
Cellular Response To Camptothecin
Nucleobase-containing Compound Metabolic Process
Nucleoplasm
Cellular Response To Radiation
Nuclear Ubiquitin Ligase Complex
Replication-born Double-strand Break Repair Via Sister Chromatid Exchange
Response To Cisplatin
Chromosome, Telomeric Region
MutLalpha Complex Binding
Telomere Maintenance Via Semi-conservative Replication
DNA Damage Response
DNA Repair
DNA Metabolic Process
Cellular Response To Stress
Nucleobase-containing Compound Metabolic Process
Nucleic Acid Metabolic Process
Nucleus
Nucleoplasm
Response To Stress
DNA Replication
DNA Recombination
Macromolecule Metabolic Process
Damaged DNA Binding
Double-strand Break Repair
DNA Biosynthetic Process
Regulation Of DNA Metabolic Process
Response To Radiation
DNA Binding
Postreplication Repair
Response To UV
Positive Regulation Of DNA Metabolic Process
DNA Synthesis Involved In DNA Repair
Recombinational Repair
Base-excision Repair
Chromosome Organization
DNA-templated DNA Replication
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Double-strand Break Repair Via Homologous Recombination
Mismatch Repair
DNA-directed DNA Polymerase Activity
Response To Light Stimulus
Translesion Synthesis
Somatic Hypermutation Of Immunoglobulin Genes
Regulation Of DNA Recombination
Negative Regulation Of Metabolic Process
DNA Clamp Loader Activity
Somatic Diversification Of Immune Receptors Via Somatic Mutation
Regulation Of Cell Cycle Phase Transition
Nucleobase-containing Compound Biosynthetic Process
Regulation Of Primary Metabolic Process
Mitotic DNA Integrity Checkpoint Signaling
Somatic Diversification Of Immunoglobulins
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Cycle Process
Negative Regulation Of DNA Metabolic Process
DNA Polymerase Activity
Somatic Cell DNA Recombination
Ctf18 RFC-like Complex
Glycolytic Process
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