FUCA1 and MED10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FUCA1	MED10
Description		alpha-L-fucosidase 1	mediator complex subunit 10
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function	Alpha-L-fucosidase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Carbohydrate Metabolic Process Fucose Metabolic Process Lipid Metabolic Process Glycoside Catabolic Process Glycolipid Catabolic Process	Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		Neutrophil degranulation Reactions specific to the complex N-glycan synthesis pathway	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases		Fucosidosis
GWAS		Arterial stiffness index ( 31235810) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		8 interacting genes: APP BARD1 CIB1 MED10 OGT PAXIP1 UBQLN2 VAV2	13 interacting genes: ABI2 ARHGDIG CEBPA ESR1 ESR2 FUCA1 HNF4A KDM4B MOB4 NAP1L1 PEBP1 SYCE1L TRIM45
Entrez ID		2517	84246
HPRD ID		01974	14680
Ensembl ID		ENSG00000179163	ENSG00000133398
Uniprot IDs		P04066	Q9BTT4
PDB IDs		7PLS 7PM4	7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Positive Regulation Of Calcium-mediated Signaling Regulation Of Glycolytic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Chromatin Organization Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Localization Negative Regulation Of MRNA 3'-end Processing Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Male Germ Cell Proliferation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of ATP Metabolic Process Intracellular Signal Transduction Regulation Of Receptor Internalization Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Proteolysis Regulation Of Signal Transduction Regulation Of Purine Nucleotide Metabolic Process Regulation Of DNA-templated Transcription Initiation Acetylcholine Receptor Activator Activity Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Regulation Of Response To Endoplasmic Reticulum Stress Macromolecule Metabolic Process Regulation Of Calcium-mediated Signaling Lipoprotein Particle Positive Regulation Of Protein Import Regulation Of Intracellular Signal Transduction Response To Radiation Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity	Nuclear Estrogen Receptor Activity Nuclear Receptor Activity Estrogen Response Element Binding Chromatin Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Steroid Binding Sequence-specific DNA Binding Chromatin Binding Cellular Response To Estradiol Stimulus Intracellular Receptor Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Ornithine Metabolic Process Intracellular Signal Transduction DNA-binding Transcription Factor Activity Response To Vitamin B2 C/EBP Complex Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Alpha-L-fucosidase Activity Zonula Adherens Assembly
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