FUCA1 and CIB1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FUCA1	CIB1
Description		alpha-L-fucosidase 1	calcium and integrin binding 1
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Cytoskeleton Plasma Membrane Membrane Apical Plasma Membrane Nuclear Body Lamellipodium Axon Growth Cone Vesicle Filopodium Tip Ruffle Membrane Sarcolemma Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery
	Molecular Function	Alpha-L-fucosidase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds	Magnesium Ion Binding Calcium Ion Binding Protein Binding Calcium-dependent Protein Kinase Inhibitor Activity Protein Serine/threonine Kinase Inhibitor Activity Small GTPase Binding Protein-membrane Adaptor Activity Transmembrane Transporter Binding Metal Ion Binding
	Biological Process	Carbohydrate Metabolic Process Fucose Metabolic Process Lipid Metabolic Process Glycoside Catabolic Process Glycolipid Catabolic Process	Angiogenesis Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell-matrix Adhesion Response To Ischemia Double-strand Break Repair Apoptotic Process DNA Damage Response Negative Regulation Of Microtubule Depolymerization Endomitotic Cell Cycle Cell Adhesion Spermatogenesis Spermatid Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Projection Development Cell Differentiation Platelet Formation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Cytoplasmic Microtubule Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Thrombopoietin-mediated Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Division Regulation Of Cell Division Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Protein Targeting To Membrane Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Plasma Membrane Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Male Germ Cell Proliferation
Pathways		Neutrophil degranulation Reactions specific to the complex N-glycan synthesis pathway
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases		Fucosidosis
GWAS		Arterial stiffness index ( 31235810) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		8 interacting genes: APP BARD1 CIB1 MED10 OGT PAXIP1 UBQLN2 VAV2	38 interacting genes: AURKB CALCB CD27 CDK4 CEACAM6 EIF4G1 ELAPOR1 EXOSC10 FEZ1 FUCA1 GLIS3 IFI6 ITGA2B LSS MAP3K5 NBR1 NCK2 NME4 NRIP1 ONECUT3 PAX3 PAX7 PLK2 PLK3 PRKDC PSEN1 PSEN2 PTK2 RAC3 SCAF1 SSX7 TERT TMEM95 TSGA10IP UBR5 WAS ZBTB49 ZDHHC17
Entrez ID		2517	10519
HPRD ID		01974	03800
Ensembl ID		ENSG00000179163	ENSG00000185043
Uniprot IDs		P04066	A0A140VK09 Q99828
PDB IDs		7PLS 7PM4	1DGU 1DGV 1XO5 1Y1A 2L4H 2L4I 2LM5 6OCX 6OD0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Positive Regulation Of Calcium-mediated Signaling Regulation Of Glycolytic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Chromatin Organization Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Localization Negative Regulation Of MRNA 3'-end Processing Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Male Germ Cell Proliferation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of ATP Metabolic Process Intracellular Signal Transduction Regulation Of Receptor Internalization Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Proteolysis Regulation Of Signal Transduction Regulation Of Purine Nucleotide Metabolic Process Regulation Of DNA-templated Transcription Initiation Acetylcholine Receptor Activator Activity Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Regulation Of Response To Endoplasmic Reticulum Stress Macromolecule Metabolic Process Regulation Of Calcium-mediated Signaling Lipoprotein Particle Positive Regulation Of Protein Import Regulation Of Intracellular Signal Transduction Response To Radiation Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity	Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Kinetochore Kinase Activity Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Aspartic Endopeptidase Activity, Intramembrane Cleaving Protein Binding Protein Kinase Activity Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Translation In Response To Stress Positive Regulation Of RNA Metabolic Process Gamma-secretase Complex Protein Serine Kinase Activity Signal Complex Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Notch Receptor Processing Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Organelle Organization Regulation Of Translation In Response To Endoplasmic Reticulum Stress Amyloid-beta Formation Protein Serine/threonine Kinase Activity Positive Regulation Of Intracellular Transport Positive Regulation Of Biosynthetic Process Dorsal/ventral Neural Tube Patterning Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Response To Stress Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Immune System Process Regulation Of RNA Metabolic Process T Cell Activation Centrosome Regulation Of Cellular Component Organization Regulation Of DNA-templated Transcription Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of RNA Biosynthetic Process Mitotic G1/S Transition Checkpoint Signaling Amyloid Precursor Protein Catabolic Process Apoptotic Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Anoikis Maturation Of 5.8S RRNA
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